scholarly journals Central obesity and nonalcoholic fatty liver disease in people living with HIV: a case for targeted screening?

HIV Medicine ◽  
2018 ◽  
Vol 20 (1) ◽  
pp. e1-e2 ◽  
Author(s):  
C Dewar ◽  
QM Anstee ◽  
DA Price ◽  
BAI Payne
2019 ◽  
Vol 13 (7) ◽  
pp. 643-650 ◽  
Author(s):  
Nicola Squillace ◽  
Alessandro Soria ◽  
Giorgio Bozzi ◽  
Andrea Gori ◽  
Alessandra Bandera

AIDS ◽  
2020 ◽  
Vol 34 (13) ◽  
pp. 1915-1921
Author(s):  
Jovana Milic ◽  
Valentina Menozzi ◽  
Filippo Schepis ◽  
Andrea Malagoli ◽  
Giulia Besutti ◽  
...  

2021 ◽  
Vol 16 (1) ◽  
pp. 59-73
Author(s):  
Amreen Dinani ◽  
Ali Khan ◽  
Douglas Dieterich

Fatty liver disease is a growing concern in people living with HIV, the main drivers are alcoholic liver disease and nonalcoholic fatty liver disease. It has shown to negatively impact HIV care continuum and result in notable non-HIV related morbidity and mortality. With the advancement in antiretroviral therapy and effective direct acting antivirals, fatty liver disease is surfacing as the next big challenge in this population like that observed in the general population. This review article summarizes the gravity of these two common diseases in HIV-infected people and aims to sheds light on an unmet need to develop effective methods to identify, screen and manage fatty liver disease in this unique population.


Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3462
Author(s):  
Cristiane Fonseca de Almeida ◽  
Paula Simplicio da Silva ◽  
Claudia Santos de Aguiar Cardoso ◽  
Nathalia Gorni Moreira ◽  
Julliana Cormack Antunes ◽  
...  

We aimed to evaluate the relationship between food intake of lipids with nonalcoholic fatty liver disease (NAFLD) and/or liver fibrosis in people living with HIV/AIDS (PLWHA). In this cross-sectional study, transient elastography was used to detect the presence of NAFLD and/or liver fibrosis. The dietary intake of fats and fatty acids (FA) were assessed by two 24 h dietary recalls (24-HDR) (n = 451). Multivariate logistic regression models were performed. Participants with higher intake of total fat were associated with higher odds for NAFLD compared to those with lower consumption [adjusted odds ratio (aOR) = 1.91 (95% confidence interval (95% CI) 1.06–3.44)]. Furthermore, participants with intermediate intake of n6-PUFA (n6-poly-unsaturated FA) and lauric FA had lower odds for NAFLD, respectively aOR = 0.54 (95% CI 0.3–0.98) and aOR = 0.42 (95% CI 0.22–0.78). Additionally, a higher intake of myristoleic FA (fourth quartile) was a significant protective factor for NAFLD [aOR = 0.56 (95% CI 0.32–0.99)]. Participants with higher intake of lauric FA [0.38 (95% CI 0.18–0.80)], myristic FA [0.38 (0.17–0.89)], palmitoleic FA [0.40 (0.19–0.82)] and oleic FA [0.35 (0.16–0.79)] had positively less odds of having liver fibrosis. On the other hand, higher intake of n-6 PUFA was significantly associated with fibrosis [aOR = 2.45 (95% CI 1.12–5.32)]. Dietary assessment of total fat and FA should be incorporated into HIV care as a tool for preventing NAFLD and fibrosis in PLWHA.


2017 ◽  
Vol 22 (1) ◽  
pp. 70 ◽  
Author(s):  
Mansour Karajibani ◽  
Farzaneh Montazerifar ◽  
AliReza Bakhshipour ◽  
Zahra Torki ◽  
AliReza Dashipour

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