scholarly journals Prospective plasma efavirenz concentration assessment in Chinese HIV-infected adults enrolled in a large multicentre study

HIV Medicine ◽  
2018 ◽  
Vol 19 (7) ◽  
pp. 440-451 ◽  
Author(s):  
F Guo ◽  
X Cheng ◽  
E Hsieh ◽  
X Du ◽  
Q Fu ◽  
...  
Keyword(s):  
Multicentre Study ◽  
Concentration Assessment ◽  
Large Multicentre Study

scholarly journals Field output factors for small fields: A large multicentre study

2021 ◽  
Vol 81 ◽  
pp. 191-196
Author(s):  
S. Dufreneix ◽  
J. Bellec ◽  
S. Josset ◽  
L. Vieillevigne
Keyword(s):  
Multicentre Study ◽  
Small Fields ◽  
Output Factors ◽  
Large Multicentre Study

scholarly journals The Value of Non-Invasive Prenatal Testing in the Diagnosis of Birth Defects: Insights from a Large Multicentre Study in Southern China

2021 ◽  
Author(s):  
Meiying Cai ◽  
Na Lin ◽  
Xuemei Chen ◽  
Ying Li ◽  
Min Lin ◽  
...  
Keyword(s):  
Multicentre Study ◽  
Pregnant Women ◽  
Chromosomal Abnormalities ◽  
Southern China ◽  
Prenatal Testing ◽  
Copy Number Variations ◽  
Trisomy 13 ◽  
Detection Rates ◽  
Non Invasive ◽  
Large Multicentre Study

Abstract Non-invasive prenatal testing (NIPT) is a fast, safe, and non-disruptive diagnostic method. At present, few studies have evaluated the screening efficiency of NIPT positive predictive value (PPV) in study subjects. Here, the results of NIPT in pregnant women were retrospectively analysed, and the detection rate, PPV and follow-up data were evaluated to determine its clinical value. A large multicentre study was conducted involving 52,855 pregnant women who received NIPT. Based on gestational age, amniotic fluid or umbilical cord blood were extracted for simultaneous karyotype and chromosome microarray analysis (CMA) in NIPT-positive patients. Among the 52,855 cases, 754 were NIPT-positive, with a positivity rate of 1.4%. Karyotype analysis and/or CMA confirmed 323 cases of chromosomal abnormalities, with a PPV of 45.1%. PPV of Trisomy 21 (T21), Trisomy 18 (T18), Trisomy 13 (T13), sex chromosomal aneuploidies (SCA) and copy number variations (CNV) were 78.9%, 35.3%, 22.2%, 36.9% and 32.9%, respectively. The PPV of T21, T18, and T13 increased with age whereas, the PPV of SCA and CNVs had little correlation with age. The PPV was significantly high in patients with advanced age along with an abnormal ultrasound.NIPT had a high PPV for T21, and a low PPV for T13 and T18, while screening for SCA and CNVs showed clinical significance. However, in case of NIPT screening for SCA and CNVs, simultaneous karyotype and CMA should be performed to increase the detection rates. Interventional prenatal diagnosis is still required in NIPT-positive cases to avoid false positives or unnecessary termination of pregnancy.

OP-120: CLINICAL OUTCOMES OF A LARGE, MULTICENTRE STUDY WITH A NEW SELF-EXPANDING PERIPHERAL STENT

2011 ◽  
Vol 147 ◽  
pp. S66-S67
Author(s):  
K. Schulte ◽  
I. Kralj ◽  
B. Koznar ◽  
H. Gissler ◽  
M. Wierzgon ◽  
...  
Keyword(s):  
Multicentre Study ◽  
Clinical Outcomes ◽  
Large Multicentre Study

scholarly journals Technical results of falloposcopy for infertility diagnosis in a large multicentre study*

2001 ◽  
Vol 16 (5) ◽  
pp. 925-930 ◽  
Author(s):  
Stefan Rimbach ◽  
Gunther Bastert ◽  
Diethelm Wallwiener
Keyword(s):  
Multicentre Study ◽  
Large Multicentre Study

scholarly journals KRAS status is related to histological phenotype in gastric cancer: results from a large multicentre study

2019 ◽  
Vol 22 (6) ◽  
pp. 1193-1203 ◽  
Author(s):  
Lindsay C. Hewitt ◽  
Yuichi Saito ◽  
Tan Wang ◽  
Yoko Matsuda ◽  
Jan Oosting ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Multicentre Study ◽  
Kras Status ◽  
Histological Phenotype ◽  
Large Multicentre Study

scholarly journals Correction to: KRAS status is related to histological phenotype in gastric cancer: results from a large multicentre study

2019 ◽  
Vol 22 (6) ◽  
pp. 1204-1205 ◽  
Author(s):  
Lindsay C. Hewitt ◽  
Yuichi Saito ◽  
Tan Wang ◽  
Yoko Matsuda ◽  
Jan Oosting ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Multicentre Study ◽  
Kras Status ◽  
Histological Phenotype ◽  
Large Multicentre Study
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