scholarly journals Screening for human papillomavirus, cervical cytological abnormalities and associated risk factors in HIV-positive and HIV-negative women in Rwanda

HIV Medicine ◽  
2017 ◽  
Vol 19 (2) ◽  
pp. 152-166 ◽  
Author(s):  
MF Mukanyangezi ◽  
V Sengpiel ◽  
O Manzi ◽  
G Tobin ◽  
S Rulisa ◽  
...  
PLoS ONE ◽  
2015 ◽  
Vol 10 (11) ◽  
pp. e0143698 ◽  
Author(s):  
Hilary A. Robbins ◽  
Christina E. Fennell ◽  
Maura Gillison ◽  
Weihong Xiao ◽  
Yingshi Guo ◽  
...  

2020 ◽  
pp. sextrans-2019-054263 ◽  
Author(s):  
Bariki Lawrence Mchome ◽  
Susanne Krüger Kjaer ◽  
Rachel Manongi ◽  
Patricia Swai ◽  
Marianne Waldstroem ◽  
...  

ObjectiveThe objective of the present study was to assess the prevalence and type-specific distribution of cervical high-risk (HR) human papillomavirus (HPV) among women with normal and abnormal cytology, and to describe risk factors for HR HPV among HIV-positive and HIV-negative women in Tanzania.MethodologyA cross-sectional study was conducted in existing cervical cancer screening clinics in Kilimanjaro and Dar es Salaam. Cervical specimens were obtained from women aged 25–60 years. Samples were shipped to Denmark for cytological examination, and to Germany for HR HPV testing (using Hybrid Capture 2) and genotyping (using LiPaExtra). Risk factors associated with HPV were assessed by multivariable logistic regression analysis.ResultAltogether, 4080 women were recruited with 3416 women contributing data for the present paper, including 609 HIV-positive women and 2807 HIV-negative women. The overall HR HPV prevalence was 18.9%, whereas the HR HPV prevalence in women with high-grade squamous intraepithelial lesions (HSILs) was 92.7%. Among HPV-positive women with HSIL, HPV16 (32.5%) and HPV58 (19.3%) were the the most common types followed by HPV18 (16.7%) and HPV52 (16.7%). Factors associated with HR HPV included younger age, increasing number of partners and early age at first intercourse. Similar risk factors were found among HIV-positive and HIV-negative women. In addition, among HIV-positive women, those with CD4 counts <200 cells/mm3 had an increased risk of HR HPV (OR 2.2; 95% CI 1.2 to 4.8) compared with individuals with CD4 count ≥500 cells/mm3.ConclusionGiven the HPV distribution among Tanzanian women, the current HPV vaccination in Tanzania using quadrivalent vaccine may be considered replaced by the nonavalent vaccine in the future. In addition, appropriate antiretroviral treatment management including monitoring of viremia may decrease the burden of HR HPV in HIV-positive women.


2020 ◽  
Vol 95 ◽  
pp. 176-182 ◽  
Author(s):  
Ongeziwe Taku ◽  
Charles B. Businge ◽  
Mana L. Mdaka ◽  
Keletso Phohlo ◽  
Wisdom Basera ◽  
...  

2013 ◽  
Vol 40 (9) ◽  
pp. 737-743 ◽  
Author(s):  
Myassa Dartell ◽  
Vibeke Rasch ◽  
Christian Munk ◽  
Crispin Kahesa ◽  
Julius Mwaiselage ◽  
...  

2018 ◽  
Vol 2 (S1) ◽  
pp. e000136
Author(s):  
Suhana Jotva ◽  
Hemani Desai ◽  
Hansa Goswami

Aims and Objectives: The aim of present study is to estimate the frequency of abnormal PAP’s smears and mainly to detect precancerous and cancerous lesions as well as inflammatory lesions in HIV infected women. Methodology: Our study was a retrospective study of total 130 cases and PAP’s smears were examined in cytology section in Department of Pathology, BJ Medical College, Ahmedabad from 1st March 2017 to 31st August 2017. Both HIV positive and HIV negative patients were included in the study. 80 patients were HIV negative and 50 patients were HIV positive. The clinical history and relevant parameters were noted. All the smears were processed by a conventional method using Papanicolaou stain.  Results: Out of 130 cases, 118 cases were reported negative for intraepithelial lesions or malignancy (NILM). Five cases were positive for squamous intraepithelial lesions (SIL) out of which four were HIV positive. Seven cases were of atypical squamous cells of undetermined significance (ASCUS) out of which 5 were HIV positive. Three cases were showing bacterial vaginosis. 1 case was showing Trichomonas Vaginalis. 19 cases were showing changes of non-specific inflammation. 6 cases were showing atrophic changes.  Conclusion: HIV infected women are at more risk to develop cervical cytological abnormalities. The study revealed a maximum number of non-specific inflammatory smears followed by smears showing atrophic changes. Smears suspicious for malignancy (ASCUS) and smears showing squamous intraepithelial lesions (SIL) were more common in HIV positive patients. Thus regular PAP’s smears screening as recommended by National AIDS Control Organization (NACO) will help in early detection of cervical abnormalities in HIV positive women. 


Author(s):  
Carlos Velo Higueras ◽  
Manuela Martín-Bejarano García ◽  
Sara Domínguez-Rodríguez ◽  
Beatriz Ruiz Sáez ◽  
Isabel Cuéllar-Flores ◽  
...  

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