scholarly journals Reference curves for CD4 T-cell count response to combination antiretroviral therapy in HIV-1-infected treatment-naïve patients

HIV Medicine ◽  
2016 ◽  
Vol 18 (1) ◽  
pp. 33-44 ◽  
Author(s):  
V Bouteloup ◽  
C Sabin ◽  
A Mocroft ◽  
L Gras ◽  
N Pantazis ◽  
...  
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
Cell Count ◽  
Cd4 T Cell ◽  
Combination Antiretroviral Therapy ◽  
Count Response ◽  
Treatment Naïve ◽  
Reference Curves ◽  
Hiv 1 ◽  
Cd4 T Cell Count

scholarly journals Sex-associated differences in pre-antiretroviral therapy plasma HIV-1 RNA in diverse areas of the world vary by CD4+ T-cell count

2011 ◽  
Vol 16 (7) ◽  
pp. 1057-1062 ◽  
Author(s):  
Beatriz Grinsztejn ◽  
◽  
Laura Smeaton ◽  
Ronald Barnett ◽  
Karin Klingman ◽  
...  
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
Cell Count ◽  
Cd4 T Cell ◽  
The World ◽  
Hiv 1 ◽  
Cd4 T Cell Count

Evolution of CD4+ T Cell Count in HIV-1-Infected Adults Receiving Antiretroviral Therapy with Sustained Long-Term Virological Suppression

2009 ◽  
Vol 25 (6) ◽  
pp. 569-576 ◽  
Author(s):  
Helen Byakwaga ◽  
John M. Murray ◽  
Kathy Petoumenos ◽  
Anthony D. Kelleher ◽  
Matthew G. Law ◽  
...  
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
Cell Count ◽  
Virological Suppression ◽  
Cd4 T Cell ◽  
Hiv 1 ◽  
Cd4 T Cell Count

scholarly journals Therapeutic Prediction of HIV-1 DNA Decay: A Multicenter Longitudinal Cohort Study

2020 ◽  
Author(s):  
Yongsong Yue ◽  
Yijia Li ◽  
Yizhi Cui ◽  
Nidan Wang ◽  
Yunda Huang ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Count ◽  
Predictive Model ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Cd4 T Cell ◽  
Peripheral Blood Mononuclear ◽  
Treatment Naïve ◽  
Hiv 1 ◽  
Cd4 T Cell Count

Abstract Background: Factors predicting peripheral blood total HIV-1 DNA size in chronically infected patients with successfully suppressed viremia remain unclear. Prognostic power of such factors are of clinical significance for making clinical decisions.Methods: Total HIV-1 DNA in blood at baseline, 12, 24, 48, 96, and 288 weeks after combined antiretroviral therapy (cART) initiation in 607 treatment-naïve patients with chronic HIV-1 infection were quantified. Generalized estimating equations and logistic regression methods were used to derive and validate a predictive model of total HIV-1 DNA after 96 weeks of cART.Results: The total HIV-1 DNA rapidly decreased from baseline [mean = 3.04 log10 copies/106 peripheral blood mononuclear cells (PBMCs)] to week 24 (mean = 2.51 log10 copies/106 PBMCs), and leveled off afterwards. Of the 490 patients who had successful HIV-1 RNA suppression by 96 w post-cART, 92 (18.8%) had a low total HIV-1 DNA count (<100 copies/106 PBMCs) at week 96. In the predictive model, lower baseline total HIV-1 DNA [risk ratio (RR) = 0.08, per 1 log10 copies/106 PBMCs, P < 0.001] and higher baseline CD4+ T cell count (RR = 1.72, per 100 cells/μL, P < 0.001) were significantly associated with a low total HIV-1 DNA count at week 96. In an independent cohort of 117 patients, this model achieved a sensitivity of 75.00% and specificity of 69.52%.Conclusions: The derived model based on baseline total HIV-1 DNA and CD4+ T cell count provides a useful prognostic tool in predicting HIV-1 DNA reservoir control during cART.

scholarly journals Alcohol Consumption and CD4 T-Cell Count Response Among Persons Initiating Antiretroviral Therapy

2012 ◽  
Vol 61 (4) ◽  
pp. 455-461 ◽  
Author(s):  
Stefan Kowalski ◽  
Elizabeth Colantuoni ◽  
Bryan Lau ◽  
Jeanne Keruly ◽  
Mary E. McCaul ◽  
...  
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
Alcohol Consumption ◽  
Cell Count ◽  
Cd4 T Cell ◽  
Count Response ◽  
Cd4 T Cell Count

scholarly journals Therapeutic Prediction of HIV-1 DNA Decay: A Multicenter Longitudinal Cohort Study

2020 ◽  
Author(s):  
Yongsong Yue ◽  
Yijia Li ◽  
Yizhi Cui ◽  
Nidan Wang ◽  
Yunda Huang ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Count ◽  
Predictive Model ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Cd4 T Cell ◽  
Peripheral Blood Mononuclear ◽  
Treatment Naïve ◽  
Hiv 1 ◽  
Cd4 T Cell Count

Abstract Background: Factors predicting peripheral blood total HIV-1 DNA size in chronically infected patients with successfully suppressed viremia remain unclear. Prognostic power of such factors are of clinical significance for making clinical decisions.Methods: Total HIV-1 DNA in blood at baseline, 12, 24, 48, 96, and 288 weeks after combined antiretroviral therapy (cART) initiation in 607 treatment-naïve patients with chronic HIV-1 infection were quantified. Generalized estimating equations and logistic regression methods were used to derive and validate a predictive model of total HIV-1 DNA after 96 weeks of cART.Results: The total HIV-1 DNA rapidly decreased from baseline [mean = 3.04 log10 copies/106 peripheral blood mononuclear cells (PBMCs)] to week 24 (mean = 2.51 log10 copies/106 PBMCs), and leveled off afterwards. Of the 490 patients who had successful HIV-1 RNA suppression by 96 w post-cART, 92 (18.8%) had a low total HIV-1 DNA count (<100 copies/106 PBMCs) at week 96. In the predictive model, lower baseline total HIV-1 DNA [risk ratio (RR) = 0.08, per 1 log10 copies/106 PBMCs, P < 0.001] and higher baseline CD4+ T cell count (RR = 1.72, per 100 cells/μL, P < 0.001) were significantly associated with a low total HIV-1 DNA count at week 96. In an independent cohort of 117 patients, this model achieved a sensitivity of 75.00% and specificity of 69.52%.Conclusions: The derived model based on baseline total HIV-1 DNA and CD4+ T cell count provides a useful prognostic tool in predicting HIV-1 DNA reservoir control during cART.

scholarly journals HIV-Related Arterial Stiffness in Malawian Adults Is Associated With the Proportion of PD-1–Expressing CD8+ T Cells and Reverses With Antiretroviral Therapy

2019 ◽  
Vol 219 (12) ◽  
pp. 1948-1958 ◽  
Author(s):  
Christine Kelly ◽  
Henry C Mwandumba ◽  
Robert S Heyderman ◽  
Kondwani Jambo ◽  
Raphael Kamng’ona ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Antiretroviral Therapy ◽  
Arterial Stiffness ◽  
Cell Count ◽  
Cd8 T Cells ◽  
Sub Saharan Africa ◽  
Cd4 T Cell ◽  
Sub Saharan ◽  
Cd4 T Cell Count

Abstract Background The contribution of immune activation to arterial stiffness and its reversibility in human immunodeficiency virus (HIV)–infected adults in sub-Saharan Africa is unknown. Methods HIV-uninfected and HIV-infected Malawian adults initiating antiretroviral therapy (ART) with a CD4+ T-cell count of &lt;100 cells/μL were enrolled and followed for 44 weeks; enrollment of infected adults occurred 2 weeks after ART initiation. We evaluated the relationship between carotid femoral pulse wave velocity (cfPWV) and T-cell activation (defined as HLA-DR+CD38+ T cells), exhaustion (define as PD-1+ T cells), and senescence (defined as CD57+ T cells) and monocyte subsets, using normal regression. Results In 279 HIV-infected and 110 HIV-uninfected adults, 142 (37%) had hypertension. HIV was independently associated with a 12% higher cfPWV (P = .02) at baseline and a 14% higher cfPWV at week 10 (P = .02), but the increases resolved by week 22. CD4+ and CD8+ T-cell exhaustion were independently associated with a higher cfPWV at baseline (P = .02). At 44 weeks, arterial stiffness improved more in those with greater decreases in the percentage of CD8+ T cells and the percentage of PD-1+CD8+ T cells (P = .01 and P = .03, respectively). When considering HIV-infected participants alone, the adjusted arterial stiffness at week 44 tended to be lower in those with higher baseline percentage of PD-1+CD8+ T cells (P = .054). Conclusions PD-1+CD8+ T-cells are associated with HIV-related arterial stiffness, which remains elevated during the first 3 months of ART. Resources to prevent cardiovascular disease in sub-Saharan Africa should focus on blood pressure reduction and individuals with a low CD4+ T-cell count during early ART.

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