Well‐differentiated lipomatous neoplasms with p53 alterations: A clinicopathologic and molecular study of eight cases with features of atypical pleomorphic lipomatous tumor

2021 ◽  
Author(s):  
Phoebe M. Hammer ◽  
Christian A. Kunder ◽  
Brooke E. Howitt ◽  
Gregory W. Charville
Keyword(s):  
Molecular Study ◽  
Lipomatous Tumor ◽  
Well Differentiated

scholarly journals MDM2 Amplified Sarcomas: A Literature Review

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 496
Author(s):  
Raf Sciot
Keyword(s):  
Suppressor Gene ◽  
Negative Regulator ◽  
Low Grade ◽  
P53 Mutations ◽  
Lipomatous Tumor ◽  
Double Minute ◽  
Genetic Features ◽  
Murine Double Minute ◽  
Well Differentiated ◽  
Mdm2 Amplification

Murine Double Minute Clone 2, located at 12q15, is an oncogene that codes for an oncoprotein of which the association with p53 was discovered 30 years ago. The most important function of MDM2 is to control p53 activity; it is in fact the best documented negative regulator of p53. Mutations of the tumor suppressor gene p53 represent the most frequent genetic change in human cancers. By overexpressing MDM2, cancer cells have another means to block p53. The sarcomas in which MDM2 amplification is a hallmark are well-differentiated liposarcoma/atypical lipomatous tumor, dedifferentiated liposarcoma, intimal sarcoma, and low-grade osteosarcoma. The purpose of this review is to summarize the typical clinical, histopathological, immunohistochemical, and genetic features of these tumors.

A Well-Differentiated Liposarcoma in the Digit: A Case Report of the 5-Year Post-Surgical Follow-Up

2018 ◽  
Vol 23 (03) ◽  
pp. 415-418
Author(s):  
Sakiko Mizuno ◽  
Kensuke Ochi ◽  
Jun Miyauchi ◽  
Itsuo Watanabe ◽  
Hiraku Hotta ◽  
...  
Keyword(s):  
Case Report ◽  
Local Recurrence ◽  
Hand Function ◽  
Middle Finger ◽  
Imaging Findings ◽  
Lipomatous Tumor ◽  
Imaging Examination ◽  
Well Differentiated

A liposarcoma is extremely rare in the digits. A 73-year-old woman was diagnosed with a lipoma in her middle finger 10 years ago. As this tumor increased in size and presented with imaging findings that were atypical of lipomas, careful marginal resection biopsy outside the pseudo-capsule was performed, and the tumor was diagnosed as a well-differentiated liposarcoma. At the 5-year follow-up, the patient showed no evidence of local recurrence or metastasis, with no loss of hand function. The findings from this case suggest that even for a lipomatous tumor in the digits, further imaging examination and resection biopsy should be considered if the tumor presents with features that are atypical of lipomas.

Orbital Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma Masquerading as Pleomorphic Lipoma

2019 ◽  
Vol 35 (3) ◽  
pp. e76-e80 ◽  
Author(s):  
Kyle McKey ◽  
Paul J. L. Zhang ◽  
Carol L. Shields ◽  
Sara E. Lally ◽  
Ralph C. Eagle ◽  
...  
Keyword(s):  
Atypical Lipomatous Tumor ◽  
Lipomatous Tumor ◽  
Pleomorphic Lipoma ◽  
Well Differentiated

scholarly journals A Retrospective Study of Superficial Type Atypical Lipomatous Tumor

2020 ◽  
Vol 7 ◽  
Author(s):  
Emi Mashima ◽  
Yu Sawada ◽  
Natsuko Saito-Sasaki ◽  
Kayo Yamamoto ◽  
Shun Ohmori ◽  
...  
Keyword(s):  
Surgical Resection ◽  
Tumor Size ◽  
Clinical Characteristics ◽  
Clinical Manifestations ◽  
Tumor Location ◽  
Atypical Lipomatous Tumor ◽  
Lipomatous Tumor ◽  
Physical Examinations ◽  
Superficial Type ◽  
Well Differentiated

Atypical lipomatous tumor (ALT) has been defined as a well-differentiated liposarcoma exhibiting a higher frequency of a local recurrence after surgical resection. ALT is mainly classified into deep type and superficial type. Compared with deep type ALT, superficial type ALT is rarely observed. One of the most important issues is that little has been known about superficial type ALT and it is not easy to predict the presence of superficial type ALT before surgical resection. To clarify the clinical manifestations of superficial type ALT, we examined 15 cases with superficial type ALT and 118 cases with benign lipoma, and analyzed their differences in clinical characteristics and the findings of MRI test. In clinical characteristics, the tumor size of superficial type ALT was significantly greater than that of benign lipoma, and superficial type ALT showed a significantly higher frequency of the tumor size of more than 4 cm. Superficial type ALT exhibited poor tumor mobility and hardness with elastic soft. In addition, a significantly higher frequency of tumor location of superficial type ALT was observed in extremities. Among tumor sites at the trunk, buttocks, and shoulder were high frequent location in superficial type ALT. In an MRI examination, superficial type ALT exhibited a significantly higher frequency of the septal structures compared with benign lipoma. The combinations of clinical characteristics, including physical examinations, MRI, and histological examinations, are helpful for the diagnosis of superficial type ALT.

scholarly journals FluorescenceIn SituHybridization forMDM2Amplification as a Routine Ancillary Diagnostic Tool for Suspected Well-Differentiated and Dedifferentiated Liposarcomas: Experience at a Tertiary Center

Sarcoma ◽  
2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Khin Thway ◽  
Jayson Wang ◽  
John Swansbury ◽  
Toon Min ◽  
Cyril Fisher
Keyword(s):  
Gene Amplification ◽  
Diagnostic Tool ◽  
Spindle Cell ◽  
Significant Group ◽  
Lipomatous Tumor ◽  
Tertiary Center ◽  
Benign Histology ◽  
Well Differentiated ◽  
Correlation Rate

Background. The assessment ofMDM2gene amplification by fluorescencein situhybridization (FISH) has become a routine ancillary tool for diagnosing atypical lipomatous tumor (ALT)/well-differentiated liposarcoma and dedifferentiated liposarcoma (WDL/DDL) in specialist sarcoma units. We describe our experience of its utility at our tertiary institute.Methods. All routine histology samples in whichMDM2amplification was assessed with FISH over a 2-year period were included, and FISH results were correlated with clinical and histologic findings.Results. 365 samples from 347 patients had FISH forMDM2gene amplification. 170 were positive (i.e., showedMDM2gene amplification), 192 were negative, and 3 were technically unsatisfactory. There were 122 histologically benign cases showing a histology:FISH concordance rate of 92.6%, 142 WDL/DDL (concordance 96.5%), and 34 cases histologically equivocal for WDL (concordance 50%). Of 64 spindle cell/pleomorphic neoplasms (in which DDL was a differential diagnosis), 21.9% showedMDM2amplification. Of the cases with discrepant histology and FISH, all but 3 had diagnoses amended following FISH results. For discrepancies of benign histology but positive FISH, lesions were on average larger, more frequently in “classical” (intra-abdominal or inguinal) sites for WDL/DDL and more frequently core biopsies. Discrepancies of malignant histology but negative FISH were smaller, less frequently in “classical” sites but again more frequently core biopsies.Conclusions. FISH has a high correlation rate with histology for cases with firm histologic diagnoses of lipoma or WDL/DDL. It is a useful ancillary diagnostic tool in histologically equivocal cases, particularly in WDL lacking significant histologic atypia or DDL without corresponding WDL component, especially in larger tumors, those from intra-abdominal or inguinal sites or core biopsies. There is a significant group of well-differentiated adipocytic neoplasms which are difficult to diagnose on morphology alone, in which FISH forMDM2amplification is diagnostically contributory.

Clinico-molecular study of dedifferentiation in well-differentiated liposarcoma

2004 ◽  
Vol 314 (4) ◽  
pp. 1133-1140 ◽  
Author(s):  
Takashi Shimoji ◽  
Hiroaki Kanda ◽  
Tomoyuki Kitagawa ◽  
Koji Kadota ◽  
Ryoichi Asai ◽  
...  
Keyword(s):  
Molecular Study ◽  
Well Differentiated

scholarly journals Well-Differentiated Liposarcoma, an Atypical Lipomatous Tumor, of the Mesentery: A Case Report and Review of the Literature

2011 ◽  
Vol 4 (1) ◽  
pp. 178-185 ◽  
Author(s):  
Takashi Yuri ◽  
Takeshi Miyaso ◽  
Hiroaki Kitade ◽  
Kosho Takasu ◽  
Nobuaki Shikata ◽  
...  
Keyword(s):  
Case Report ◽  
Review Of The Literature ◽  
Atypical Lipomatous Tumor ◽  
Lipomatous Tumor ◽  
Well Differentiated
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