High Interobserver Variability and Frequent Overdiagnosis of Dysplasia in Fundic Gland Polyps can be Improved by Detecting Atypia on Surface Epithelium and An Abrupt Transition to Non‐Neoplastic Cells

2021 ◽  
Author(s):  
Christine E. Orr ◽  
Debra Beneck ◽  
Jose Jessurun ◽  
Lihui Qin ◽  
Kathrin Tyryshkin ◽  
...  
Keyword(s):  
Interobserver Variability ◽  
Surface Epithelium ◽  
Fundic Gland ◽  
Neoplastic Cells ◽  
Abrupt Transition ◽  
Fundic Gland Polyps

scholarly journals Prevalence of gastric polypoid lesions in a single endoscopic centre

2013 ◽  
Vol 154 (20) ◽  
pp. 770-774
Author(s):  
Ágnes Anna Csontos ◽  
Bálint Fekete ◽  
Katalin Lőrinczy ◽  
Orsolya Terjék ◽  
Lajos Berczi ◽  
...  
Keyword(s):  
Proton Pump Inhibitor ◽  
Proton Pump ◽  
Chronic Gastritis ◽  
Malignant Lesion ◽  
Fundic Gland ◽  
Hyperplastic Polyps ◽  
Gastric Polyps ◽  
Fundic Gland Polyps ◽  
Upper Gastrointestinal

Background: The prevalence of gastric polyps is unknown in Hungary. Aim: The aim of the authors was to assess the prevalence of polypoid lesions of the stomach in the endoscopic centre of the 2nd Department of Medicine, Semmelweis University. Methods: Results of upper gastrointestinal endoscopies carried out between March 2010 and June 2011 were analysed. Results: 193 cases with polyps were diagnosed in 4174 endoscopies (4.62%). Hyperplastic polyps, fundic gland polyps and malignant lesion were detected in 33.67%, 31.09% and 2.07% of the cases, respectively. Proton pump inhibitor use was more frequent among patients diagnosed with fundus gland polyps (p = 0.007), while hyperplastic polyps were diagnosed more frequently in patients with chronic gastritis (p = 0.032). Conclusions: The frequency of gastric polyps was higher than expected from data published in the literature. Long-term proton pump-inhibitor use and chronic gastritis were associated with fundus gland and hyperplastic polyps, respectively. Orv. Hetil., 2013, 154, 770–774.

Trefoil Peptides, E-cadherin, and β-catenin Expression in Sporadic Fundic Gland Polyps

2009 ◽  
Vol 17 (5) ◽  
pp. 431-437 ◽  
Author(s):  
Anna DʼOdorico ◽  
Mauro Cassaro ◽  
Sabina Grillo ◽  
Roberta Lazzari ◽  
Andrea Buda ◽  
...  
Keyword(s):  
Fundic Gland ◽  
Trefoil Peptides ◽  
Fundic Gland Polyps ◽  
E Cadherin

scholarly journals Fundic Gland Polyps in Familial Adenomatous Polyposis

2000 ◽  
Vol 157 (3) ◽  
pp. 747-754 ◽  
Author(s):  
Susan C. Abraham ◽  
Bunsei Nobukawa ◽  
Francis M. Giardiello ◽  
Stanley R. Hamilton ◽  
Tsung-Teh Wu
Keyword(s):  
Familial Adenomatous Polyposis ◽  
Fundic Gland ◽  
Adenomatous Polyposis ◽  
Fundic Gland Polyps

scholarly journals AGREEMENT BETWEEN DIFFERENT PATHOLOGISTS IN HISTOPATHOLOGIC DIAGNOSIS OF 128 GASTRIC POLYPS

2017 ◽  
Vol 54 (3) ◽  
pp. 263-266 ◽  
Author(s):  
Sérgio Henrique Brito BARBOSA ◽  
Geraldo Cezário de LÁZARO FILHO ◽  
Luciano Monteiro FRANCO ◽  
José Telmo VALENÇA JUNIOR ◽  
Miguel Ângelo NOBRE E SOUZA ◽  
...  
Keyword(s):  
University Hospital ◽  
Histopathological Diagnosis ◽  
Fundic Gland ◽  
Digestive Endoscopy ◽  
Hyperplastic Polyps ◽  
Kappa Index ◽  
Substantial Agreement ◽  
Gastric Polyps ◽  
Fundic Gland Polyps ◽  
Histopathologic Diagnosis

ABSTRACT BACKGROUND - Gastric polyps are elevated mucosal lesions. Most of them are less than 1 cm and when larger than 2 cm, has a high malignancy probability. The histopathological types are mainly fundic gland polyps, hyperplastic polyps and adenomatous polyps. OBJECTIVE - To evaluate the agreement between three different pathologists in the histopathological diagnosis of 128 biopsied gastric polyps in Digestive Endoscopy Unit from Walter Cantídeo University Hospital, between May 2010 to May 2012. METHODS - To describe the intensity of agreement between observers, we use kappa index that is based on the number of concordant measures between them. RESULTS - There was substantial agreement in the diagnosis of adenoma (kappa=0.799, CI: 0.899-0.698) and fundic glands (kappa=0.655, CI: 0.755-0.555). Regarding to hyperplastic polyps (kappa=0.415, CI: 0.515-0.315) and inflammatory (kappa=0.401, CI: 0.501-0.301), we obtained a moderate agreement. Regarding the presence of Helicobacter pylori in biopsy of the polyp, there was a low agreement (kappa=0.219, CI: 0.319-0.119). CONCLUSION - It is clear that the agreement between pathologists depends on the histological type of the biopsied polyp and this agreement is more substantial in adenoma, or fundic gland polyps.

scholarly journals GASTRIC FUNDIC GLAND POLYPS: CAN HISTOLOGY BE USEFUL TO PREDICT PROTON PUMP INHIBITORS USE?

2018 ◽  
Vol 55 (4) ◽  
pp. 380-384
Author(s):  
Hugo Leite de Farias BRITO ◽  
Cynthia BARROS ◽  
Marcelle Vieira FREIRE ◽  
Miraldo Nascimento da SILVA FILHO ◽  
Tereza Virgínia NASCIMENTO
Keyword(s):  
Proton Pump Inhibitor ◽  
Proton Pump Inhibitors ◽  
Parietal Cell ◽  
Proton Pump ◽  
Proton Pump Inhibitor Therapy ◽  
Inhibitor Therapy ◽  
Fundic Gland ◽  
Acid Therapy ◽  
Fundic Gland Polyps ◽  
Two Samples

ABSTRACT BACKGROUND: Fundic gland polyps allegedly increased in frequency in recent decades, and had attracted great attention due to possible association with prolonged proton pump inhibitor therapy. Prolonged use of this drug could cause parietal cell hyperplasia, obstruction of glandular lumen and cystic dilation of the gland. OBJECTIVE: This study aims to analyze clinical and pathological features of fundic gland polyps in patients with and without proton pump inhibitor therapy in a selected population from Brazil. METHODS: It was selected a sample of 101 Brazilian patients (78 females and 23 males), from a five years retrospective search of the files from a private pathology laboratory. The patients had an average age of 57 years and we included patients with a histological diagnosis of fundic gland polyp. The clinical data were obtained from their files and all histological slides were reviewed and examined with hematoxylin and eosin (HE) and Giemsa. RESULTS: Information about the use or non-use of proton pump inhibitors (PPI) was obtained in 84 patient files. In 17 cases we could not determine if PPI were used or not. Among those in which the information was available, a positive history of anti-acid therapy was observed in 63 (75.0%) patients. Parietal cell hypertrophy/hyperplasia and parietal cell protrusions were detected in most slides. Histological findings were identical in PPI users and PPI negative patients. Helicobacter pylori infection was detected in just two samples. Epithelial dysplasia or adenocarcinoma were not observed in our cases. Histopathological analysis of fundic gland polyps could not distinguish between PPI and non-PPI related cases. Parietal cell cytoplasmic protrusions, an alleged marker of prolonged acid suppression therapy, was detected in both groups. CONCLUSION: Histological features could not discriminate anti-acid therapy related fundic glands polyps in our patients.

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