scholarly journals Dysembryoplastic Neuroepithelial Tumor (DNT). A series of 15 cases from Pakistan. Clinicopathological features and detailed review of literature

2021 ◽  
Vol 79 (S1) ◽  
pp. 26-27
2012 ◽  
Vol 3 (2) ◽  
pp. 94-101
Author(s):  
Shamimul Hasan ◽  
Nabeel Ishrat khan ◽  
Ali Asger Nakeb ◽  
Fauzia Tarranum

2013 ◽  
Vol 59 (9) ◽  
pp. e132-e136 ◽  
Author(s):  
C. Giraudo ◽  
N. Nannini ◽  
E. Balestro ◽  
A. Meneghin ◽  
F. Lunardi ◽  
...  

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Nasir Ud Din ◽  
Shabina Rahim ◽  
Tamana Asghari ◽  
Jamshid Abdul-Ghafar ◽  
Zubair Ahmad

Abstract Background Hepatic epithelioid hemangioendothelioma is an extremely rare malignant vascular tumor which is often multifocal and, in many cases, discovered incidentally. Here, we describe the clinicopathological features of hepatic epithelioid hemangioendothelioma cases seen in our practice and present a detailed review of the published literature. Methods All cases of hepatic epithelioid hemangioendothelioma diagnosed in Department of Pathology and Laboratory Medicine, Aga Khan University Hospital between January 1, 2006 and December 31, 2019 were included in the study. Slides were reviewed and follow up was obtained. Results Seven cases were reported during the study period. There were 4 females and 3 males. Age range was 20 to 77 years, mean age was 45 years. Three patients presented with right upper abdominal pain; 1 patient presented with jaundice while 3 patients were asymptomatic. In all 7 cases, lesions were identified on imaging studies. In 5 cases, liver lesions were multifocal. Clinical differential diagnosis in all cases was metastatic carcinoma and multifocal hepatocellular carcinoma. Liver function tests were normal in 5 cases. In 1 patient, tumor had already metastasized to the right lung. On histological examination of liver core biopsies performed in all 7 cases, classic histological features of epithelioid hemangioendothelioma were seen. Tumor cells expressed positivity for vascular markers (CD 34, CD31 and ERG) and were negative for cytokeratins, Hep par 1 and Glypican 3. Surgical resection was not performed in any of the 7 cases and all patients were treated by chemotherapy. Follow up was available in 5 cases. Of these, 3 patients died of disease and another patient was alive with metastases in both lungs, omentum and colon. Conclusion Clinicopathological features of the 7 cases in our series and detailed review of published literature is presented. Prognosis was bad in our cases most likely due to fact that surgical resection could not be performed in any of the cases owing to lack of surgical expertise for liver tumor surgery in most parts of the country.


2010 ◽  
Vol 3 (2) ◽  
pp. 73-75
Author(s):  
SH Chandrashekharayya ◽  
SS Suligavi ◽  
Sachin Chougule ◽  
SS Doddamani

Abstract Rhinosporidiosis is a rare chronic granulomatous disease caused by rhinosporidium seeberi. Nasal rhinosporidiosis presents with nasal mass, nasal obstruction and epistaxis. In this study, we present our experience in 17 patients of rhinosporidiosis. Diagnosis was made on clinicopathological features. Different clinical presentations, management by surgical, combined with medical line of treatment are discussed with review of literature


Neurosurgery ◽  
1988 ◽  
Vol 23 (5) ◽  
pp. 545-556 ◽  
Author(s):  
Catherine Daumas-Duport ◽  
Bernd W. Scheithauer ◽  
Jean-Paul Chodkiewicz ◽  
Edward R. Laws ◽  
Claude Vedrenne

Abstract This report concerns the clinicopathological features of 39 cases of a morphologically unique and surgically curable group of neuroepithelial tumors associated with medically intractable partial complex seizures. All were supratentorial and characterized by intracortical location, multinodular architecture, and heterogeneity in cellular composition. The constituent cells included astrocytes, oligodendrocytes, and neurons. Because neuronal atypia was often inapparent, the tumors superficially resembled mixed oligoastrocytomas. The term “dysembryoplastic neuroepithelial tumor” (DNT) is proposed for these distinctive lesions, the clinicopathological features of which suggest a dysembryoplastic origin. With the exception of the occurrence of headaches in 2 patients, partial complex seizures were the exclusive symptom. Age at onset of symptoms ranged from 1 to 19 years (mean 9 years). In addition to the chronic nature of the seizures (range, 2 to 18 years; mean, 9 years), one-third of the patients showed radiological features, such as focal cranial deformity, indicating that the tumors had an early onset and were of long standing. In most cases, computed tomography showed a “pseudocystic,” well-demarcated, low density appearance associated in some cases with focal contrast enhancement (18%) or calcific hyperdensity (23%). The tumor involved the temporal lobe in 24 patients (62%), the frontal lobe in 12 (31%), and the parietal and/or occipital lobe in 3 cases. Although tumor removal was considered incomplete or subtotal in 17 patients (44%), long term follow-up (range, 1 to 18 years; mean, 9 years) showed neither clinical nor radiological evidence of recurrence in any patient. Comparison of the survival data of the 13 subjects who had undergone postoperative radiotherapy with 26 who had not indicated that radiation therapy was of no obvious benefit. The identification of DNT has therapeutic and prognostic implications because aggressive therapy can be avoided, thus sparing these young patients the deleterious long term effects of radio- or chemotherapy.


2020 ◽  
Vol 28 (8) ◽  
pp. 913-917
Author(s):  
Vinita Agrawal ◽  
Zafar Neyaz ◽  
Rakesh Kapoor

Thyroid-like follicular carcinoma of kidney (TLFCK) is a morphological subtype of renal cell carcinoma, which is included as an emerging/provisional entity in the classification of renal tumors, with only about 40 cases reported in literature. It has a distinct histological appearance and immunohistochemical profile as compared with other renal cell cancers. However, these tumors, while appearing distinctive, have not been characterized fully either morphologically or by ancillary techniques. The reported cases show variable demographical and clinical features. Most are indolent, while some present with metastasis. The histological, immunohistochemical, and ultrastructural features of a case of TLFCK with clusters of oncocytic cells and pseudosarcomatous stroma are presented. Follow-up of 5 years was uneventful. A review of literature to analyze features in metastatic as compared with non-metastatic TLFCK is discussed. We report a patient of TLFCK and compare the clinicopathological features of metastatic and non-metastatic tumors.


2017 ◽  
Vol 57 (1) ◽  
pp. 26-30 ◽  
Author(s):  
Keisuke Kawamoto ◽  
Hiroaki Miyoshi ◽  
Takaharu Suzuki ◽  
Reiji Muto ◽  
Kyohei Yamada ◽  
...  

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