Paratesticular endometrioid adenocarcinoma of ovarian surface epithelial type with neuroendocrine differentiation: An undescribed entity

2021 ◽  
Author(s):  
Apurva Mundada ◽  
Aanchal Kakkar ◽  
Santosh Menon
Keyword(s):  
Neuroendocrine Differentiation ◽  
Endometrioid Adenocarcinoma ◽  
Ovarian Surface ◽  
Ovarian Surface Epithelial

Reciprocal Interactions between Human Ovarian Surface Epithelial Cells and Adjacent Extracellular Matrix

1994 ◽  
Vol 215 (1) ◽  
pp. 97-108 ◽  
Author(s):  
Patricia A. Kruk ◽  
Veli-Jukka Uitto ◽  
James D. Firth ◽  
Shoukat Dedhar ◽  
Nelly Auersperg
Keyword(s):  
Extracellular Matrix ◽  
Epithelial Cells ◽  
Reciprocal Interactions ◽  
Ovarian Surface ◽  
Ovarian Surface Epithelial

Microenvironmental Regulation of BRCA1 Gene Expression by c-Jun and Fra2 in Premalignant Human Ovarian Surface Epithelial Cells

2013 ◽  
Vol 11 (3) ◽  
pp. 272-281 ◽  
Author(s):  
Lixin Zhou ◽  
Marcia Graves ◽  
Gwen MacDonald ◽  
Jane Cipollone ◽  
Christopher R. Mueller ◽  
...  
Keyword(s):  
Gene Expression ◽  
Epithelial Cells ◽  
Brca1 Gene ◽  
Ovarian Surface ◽  
Ovarian Surface Epithelial

Nonrandom chromosomal imbalances in human ovarian surface epithelial cells immortalized by HPV16-E6E7 viral oncogenes

2001 ◽  
Vol 130 (2) ◽  
pp. 141-149 ◽  
Author(s):  
Sai Wah Tsao ◽  
Natalie Wong ◽  
Xianghong Wang ◽  
Yu Liu ◽  
Thomas Shek Kong Wan ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Chromosomal Imbalances ◽  
Viral Oncogenes ◽  
Ovarian Surface ◽  
Ovarian Surface Epithelial

scholarly journals Most Commonly Mutated Genes in High-Grade Serous Ovarian Carcinoma Are Nonessential for Ovarian Surface Epithelial Stem Cell Transformation

Cell Reports ◽  
2020 ◽  
Vol 32 (9) ◽  
pp. 108086
Author(s):  
Robert Joseph Yamulla ◽  
Shreya Nalubola ◽  
Andrea Flesken-Nikitin ◽  
Alexander Yu Nikitin ◽  
John C. Schimenti
Keyword(s):  
Stem Cell ◽  
Ovarian Carcinoma ◽  
Cell Transformation ◽  
High Grade ◽  
Epithelial Stem Cell ◽  
Ovarian Surface ◽  
Serous Ovarian Carcinoma ◽  
Ovarian Surface Epithelial

Intermediate filaments in rat ovarian surface epithelial cells: changes with neoplastic progression in culture

1992 ◽  
Vol 70 (1) ◽  
pp. 16-25 ◽  
Author(s):  
Ann E. Hornby ◽  
Jie Pan ◽  
Nelly Auersperg
Keyword(s):  
Cell Density ◽  
Intermediate Filaments ◽  
Growth Pattern ◽  
Primary Cultures ◽  
Neoplastic Progression ◽  
Western Blots ◽  
Ovarian Surface ◽  
Keratin Expression ◽  
Keratin Filaments ◽  
Ovarian Surface Epithelial

Interrelationships between neoplastic progression and the expression of intermediate filaments were examined in primary cultures, immortal lines, and Kirsten murine sarcoma virus (KiMSV) transformed lines of rat ovarian surface epithelial (ROSE) cells. Immunofluorescence microscopy revealed abundant keratin filaments in all cells of primary cultures. In immortal, nontumorigenic lines, keratin filaments were detected in fewer cells, in smaller numbers, and in microscopically altered forms. The percentage of keratin-positive cells ranged from 4 to 54%. Its expression was inversely proportional to cell density. Keratin expression was similar in the two immortal lines, although one had retained a monolayered epithelial growth pattern resembling primary cultures, while in the other the growth pattern of the cells was more atypical. The two KiMSV-transformed lines were previously shown to produce tumors in vivo that resemble human ovarian endometrioid stromal sarcomas. In spite of this histologic appearance, the proportion of keratin-positive cells in these cells was increased over the immortal lines. Keratin expression was unrelated to cell density, and keratin in most virally transformed cells was limited to few, fine filaments. In thymidine-labelled immortal and virus-transformed cultures stained for keratin, no correlation was found between keratin expression and proliferative activity. The keratin profiles of primary and immortal cultures were identical on Western blots, with subtypes ranging from 52 to 66 kDa. The two virally transformed lines lacked some of the subtypes. Vimentin networks were faint or absent in primary cultures. In the immortal and the virus-transformed lines, neoplastic progression was associated with increasing vimentin expression but with no changes in filament morphology and distribution. The results show that the abnormalities in intermediate filament expression that accompany immortalization do not preclude the retention of a normal epithelial morphology and growth pattern in this cell type. Furthermore, the number of intermediate filaments and their intracellular distribution appear to be altered at an earlier stage in neoplastic progression than those mechanisms that select for specific keratin subtypes, or those that respond to regulation by cell density. Finally, the presence of keratin in the KiMSV-transformed lines examined in this study supports the hypothesis that human ovarian stromal sarcomas can arise in the OSE.Key words: neoplastic transformation, keratin, vimentin, cytoskeleton, ras oncogene, ovary, tissue culture.

scholarly journals Thyroid Hormone Signaling in Human Ovarian Surface Epithelial Cells

2007 ◽  
Vol 92 (1) ◽  
pp. 322-327 ◽  
Author(s):  
M. T. Rae ◽  
O. Gubbay ◽  
A. Kostogiannou ◽  
D. Price ◽  
H. O. D. Critchley ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Thyroid Hormone ◽  
Mrna Expression ◽  
Cell Cultures ◽  
Nuclear Hormone Receptor ◽  
Rt Pcr ◽  
Ovarian Surface ◽  
Increased Risk ◽  
Ovarian Surface Epithelial

Abstract Context: Ovarian surface epithelial (OSE) cells express multiple nuclear hormone receptor genes, including those encoding thyroid hormone and estrogen receptors (TR and ER, respectively). Ovarian cancer is hormone-dependent, and epidemiological evidence links hyperthyroidism, inflammation of the ovarian surface, and increased risk of ovarian cancer. Objective: The objective of this study was to assess T3 action on human OSE cells in vitro, asking 1) is there evidence for (pre)receptor control, 2) is T3 inflammatory, and 3) does T3 affect ER expression? Design: Immunohistochemical analysis of fixed human ovaries and in vitro analysis of human OSE primary cell cultures were performed. Patients: Twelve women aged 29–50 yr (median, 41 yr) undergoing elective gynecological surgery for nonmalignant conditions were studied. Results: Messenger RNA transcripts for TRα1, TRα2, TRβ1, and T3 activating deiodinase 2 and inactivating deiodinase 3 were present in primary OSE cell cultures by RT-PCR. TRα and TRβ proteins were also localized to intact OSE by immunohistochemistry. Treatment of OSE cell cultures for 24 h with T3 caused dose-dependent mRNA expression of inflammation-associated genes: cyclooxygenase-2, matrix metalloproteinase-9, and 11βhydroxysteroid dehydrogenase type 1, determined by quantitative RT-PCR. Finally, treatment with T3 dose dependently stimulated ERα mRNA expression without affecting ERβ1 or ERβ2. Conclusion: The ovarian surface is a potential T3 target. T3 exerts direct inflammatory effects on OSE cell function in vitro. OSE cell responses to T3 include increased expression of ERα mRNA, which encodes the ER isoform most strongly associated with ovarian cancer. This could help explain suggested epidemiological links between hyperthyroidism and ovarian cancer.

Sign in / Sign up

Export Citation Format

Share Document