High CD8+ tumour infiltrating lymphocyte density associates with unfavourable prognosis in oesophageal adenocarcinoma following poor response to neo‐adjuvant chemoradiotherapy

2021 ◽  
Author(s):  
W.J. Koemans ◽  
J.M. van Dieren ◽  
J. van den Berg ◽  
G. Meijer ◽  
P. Snaebjornsson ◽  
...  
Keyword(s):  
Poor Response ◽  
Oesophageal Adenocarcinoma ◽  
Adjuvant Chemoradiotherapy ◽  
Unfavourable Prognosis

642 PL02.01 DOES A HIGH MANDARD SCORE REALLY DEFINE A POOR RESPONSE TO CHEMOTHERAPY IN OESOPHAGEAL ADENOCARCINOMA?

2021 ◽  
Vol 34 (Supplement_1) ◽  
Author(s):  
William Knight ◽  
Cara Baker ◽  
Nyree Griffin ◽  
Mark Kelly ◽  
Andrew Davies ◽  
...  
Keyword(s):  
Cox Regression ◽  
Primary Tumour ◽  
Poor Response ◽  
Tumour Volume ◽  
Volume Reduction ◽  
Oesophageal Adenocarcinoma ◽  
Recurrence Rates ◽  
Time To Death ◽  
Response To Chemotherapy ◽  
Significant Difference

Abstract   A high Mandard score corresponds to a non-response to chemotherapy in the primary tumour in oesophageal adenocarcinoma. However, some patients experience tumour volume reduction and a nodal downstaging despite a high score. This study compares survival and recurrence patterns in these patients. Methods Clinicopathological factors were analysed using multivariable Cox regression assessing time to death and recurrence. CT estimated tumour volume change was examined in a subgroup of consecutive patients. Mean pre-chemotherapy and post chemotherapy tumour volumes were compared across Mandard groups and nodal responders. Results 555 patients were included. Median survival was 55 months (Mandard 1,2,3) and 21 months (Mandard 4,5). In the Mandard 4,5 group (332 patients), comparison between complete nodal responders and persistent nodal disease showed improved survival (90 vs 18 months), recurrence rates (locoregional 14.75% vs 28.74, systemic 24.59% vs 48.42%) and CRM positivity (22.95% vs 68.11). Complete nodal response independently predicted improved survival (HR 0.34(0.16–0.74). Post-chemotherapy tumour volume reduction was greater in patients with a complete nodal response (−16.3 cm3 vs −7.7 cm3 p 0.033) with no significant difference between Mandard groups. Conclusion: Patients with a complete nodal response to chemotherapy have significantly improved outcomes despite a poor Mandard score. High Mandard score does not correspond with a non-response to chemotherapy in all cases and patients with nodal downstaging may still benefit from adjuvant chemotherapy.

Does a high Mandard score really define a poor response to chemotherapy in oesophageal adenocarcinoma?

2021 ◽  
Author(s):  
William R. C. Knight ◽  
◽  
Cara R. Baker ◽  
Nyree Griffin ◽  
Wahyu Wulaningsih ◽  
...  
Keyword(s):  
Poor Response ◽  
Oesophageal Adenocarcinoma ◽  
Response To Chemotherapy

Role of cyclooxygenase-2 in the development and treatment of oesophageal adenocarcinoma

2003 ◽  
Vol 38 (0) ◽  
pp. 87-93 ◽  
Author(s):  
C. J. Buskens ◽  
Ristimäki A. ◽  
G. J. A. Offerhaus ◽  
D. J. Richel ◽  
J. J. B. van Lanschot
Keyword(s):  
Cyclooxygenase 2 ◽  
Oesophageal Adenocarcinoma

Peritraumatic Reactions: Predictors of Poor Response to Pharmacological Treatment for PTSD

2008 ◽  
Author(s):  
Adriana Fiszman ◽  
Mauro V. Mendlowicz ◽  
Carla Marques-Portella ◽  
Eliane Volchan ◽  
Evandro S. F. Coutinho ◽  
...  
Keyword(s):  
Pharmacological Treatment ◽  
Poor Response ◽  
Peritraumatic Reactions

Malignant tumours as a rare cause of recurrent thrombophlebitis of the great saphenous vein

Phlebologie ◽  
2008 ◽  
Vol 37 (06) ◽  
pp. 297-300
Author(s):  
N. König ◽  
H. J. Stark ◽  
P.-M. Baier
Keyword(s):  
Differential Diagnosis ◽  
Saphenous Vein ◽  
Great Saphenous Vein ◽  
Case Reports ◽  
Malignant Tumours ◽  
Nerve Sheath Tumour ◽  
Below The Knee ◽  
Nerve Sheath ◽  
Unfavourable Prognosis ◽  
Peripheral Nerve Sheath Tumour

SummaryWe present two case reports concerning patients who had to undergone surgical treatment according tp the diagnosis of thrombophlebitis with insufficiency of the greater saphenous vein and putative encapsulated haematoma in the lower left leg area. During the operation we found tumours with urgent suspicion of malignancy. The histological examination revealed the diagnosis of mesenchymal chondrosarcoma and malignant peripheral nerve sheath tumour which are extremely malignant, but very rare neoplasmas with unfavourable prognosis. Conclusion: Since both types of tumours are often located below the knee, phlebotomists and vascular surgeons should take them into account as differential diagnosis.

Significance of Reduced Protein C in Patients with Acute Stroke and Unfavourable Prognosis

1988 ◽  
Vol 60 (02) ◽  
pp. 345 ◽  
Author(s):  
A D’Angelo ◽  
G Landi ◽  
L Candelise ◽  
E Nobile Orazio ◽  
S Vigano-D’Angelo ◽  
...  
Keyword(s):  
Acute Stroke ◽  
Protein C ◽  
Unfavourable Prognosis

The Use of Desmopressin Acetate (DDAVP) as a Test of the Fibrinolytic Capacity of Patients – Analysis of Responders and Non-Responders

1982 ◽  
Vol 48 (02) ◽  
pp. 156-161 ◽  
Author(s):  
E J P Brommer ◽  
M M Barrett-Bergshoeff ◽  
R A Allen ◽  
I Schicht ◽  
R M Bertina ◽  
...  
Keyword(s):  
Renal Insufficiency ◽  
Plasminogen Activator ◽  
Vascular Endothelium ◽  
Fibrinolytic Activity ◽  
Baseline Level ◽  
Poor Response ◽  
Facial Flushing ◽  
Spontaneous Thrombosis ◽  
Type Iv ◽  
Fibrinolytic Capacity

SummaryIntravenous infusion of desmopressin (DDAVP, 0.4 μg/kg b.w. in 12’) causes an increase in the level of extrinsic plasminogen activator, measured in plasma euglobulin fractions with added C1-inactivator on fibrin plates. A poor response or no response at all was elicited in two out of 21 patients with spontaneous thrombosis, 18/38 with hyperlipoproteinaemia and 10/14 with terminal renal insufficiency requiring haemodialysis.Haemodilution during the first 30’ after starting the DDAVP-infusion occurred both in responders and in non-responders; so did haemodynamic reactions: increase in heart rate, drop in diastolic blood pressure, facial flushing. The rise of fibrinolytic activity was shown not to be associated with decreased hepatic blood flow. Normal factor VIII-rises in “non-responders” indicate the responsiveness of the receptive organs, including the hypothalamus, to DDAVP.Despite a normal baseline level of fibrinolytic activity in the blood, as occurs for instance in terminal renal insufficiency, the vascular endothelium may be refractory to stimulation. In some patients, especially in type IV hyperlipoproteinaemia, a selective defect of the release of plasminogen activator is postulated. In subjects with low fibrinolytic activity at rest, as observed in spontaneous thromboembolism and in hypertriglyceridaemia, the failure to release plasminogen activator upon stimulation with DDAVP might be a consequence of an impairment of synthesis as well.

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