p16 Overexpression and Rb Loss Correlate with High‐risk HPV Infection in Oropharyngeal Squamous Cell Carcinoma

2021 ◽  
Author(s):  
Rina Jiromaru ◽  
Hidetaka Yamamoto ◽  
Ryuji Yasumatsu ◽  
Takahiro Hongo ◽  
Yui Nozaki ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
High Risk ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Hpv Infection ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
High Risk Hpv ◽  
P16 Overexpression

scholarly journals Brush cytology for the detection of high-risk HPV infection in oropharyngeal squamous cell carcinoma

2015 ◽  
Vol 123 (12) ◽  
pp. 732-738 ◽  
Author(s):  
Martina A. Broglie ◽  
Wolfram Jochum ◽  
Diana Förbs ◽  
René Schönegg ◽  
Sandro J. Stoeckli
Keyword(s):  
Squamous Cell Carcinoma ◽  
High Risk ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Hpv Infection ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Brush Cytology ◽  
High Risk Hpv

scholarly journals Correlation of EGFR, pEGFR and p16INK4 expressions and high risk HPV infection in HIV/AIDS-related squamous cell carcinoma of conjunctiva

2014 ◽  
Vol 9 (1) ◽  
pp. 7 ◽  
Author(s):  
Anthony Mwololo ◽  
Joshua Nyagol ◽  
Emily Rogena ◽  
Willis Ochuk ◽  
Mary Kimani ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
High Risk ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Hpv Infection ◽  
High Risk Hpv ◽  
Hiv Aids

High-risk HPV and survival in patients with oral and oropharyngeal squamous cell carcinoma – 5-year follow up of a population-based study

2014 ◽  
Vol 134 (8) ◽  
pp. 843-851 ◽  
Author(s):  
Karin Annertz ◽  
Kerstin Rosenquist ◽  
Gunilla Andersson ◽  
Helene Jacobsson ◽  
Bengt Göran Hansson ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
High Risk ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Population Based ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Population Based Study ◽  
High Risk Hpv

Preoperative18F-FDG PET/CT and high-risk HPV in patients with oropharyngeal squamous cell carcinoma

Head & Neck ◽  
2013 ◽  
Vol 36 (3) ◽  
pp. 323-327 ◽  
Author(s):  
Young-Hoon Joo ◽  
Ie-Ryung Yoo ◽  
Kwang-Jae Cho ◽  
Jun-Ook Park ◽  
In-Chul Nam ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
High Risk ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Fdg Pet ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
High Risk Hpv

P179 High risk HPV infection is associated with oral squamous cell carcinoma in Mexican patients: a case control study

2007 ◽  
Vol 2 (1) ◽  
pp. 185
Author(s):  
G. Anaya-Saavedra ◽  
V.A. Ramírez-Amador ◽  
M.E. Irigoyen-Camacho ◽  
C.M. García-Cuellar ◽  
A. García-Cuellar
Keyword(s):  
Squamous Cell Carcinoma ◽  
High Risk ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Case Control Study ◽  
Hpv Infection ◽  
Case Control ◽  
High Risk Hpv ◽  
Control Study

scholarly journals Genomic Integration of High-Risk HPV Alters Gene Expression in Oropharyngeal Squamous Cell Carcinoma

2016 ◽  
Vol 14 (10) ◽  
pp. 941-952 ◽  
Author(s):  
Heather M. Walline ◽  
Christine M. Komarck ◽  
Jonathan B. McHugh ◽  
Emily L. Bellile ◽  
J. Chad Brenner ◽  
...  
Keyword(s):  
Gene Expression ◽  
Squamous Cell Carcinoma ◽  
High Risk ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Genomic Integration ◽  
High Risk Hpv

In situ hybridization for high risk HPV E6/E7 mRNA in oropharyngeal squamous cell carcinoma

2021 ◽  
Vol 42 (1) ◽  
pp. 102782
Author(s):  
Krish Suresh ◽  
Parth V. Shah ◽  
Sydney Coates ◽  
Borislav A. Alexiev ◽  
Sandeep Samant
Keyword(s):  
Squamous Cell Carcinoma ◽  
In Situ Hybridization ◽  
High Risk ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Hpv E6 ◽  
High Risk Hpv

scholarly journals The Prevalence of Human Papillomavirus–Positive Oropharyngeal Squamous Cell Carcinoma at One of the Largest Tertiary Care Centers in Sub-Saharan Africa

2021 ◽  
Author(s):  
Gloria Dapaah ◽  
Jos Hille ◽  
William C. Faquin ◽  
Judith Whittaker ◽  
Corneli M. Dittrich ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
High Risk ◽  
Positive Predictive Value ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Predictive Value ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Sub Saharan Africa ◽  
High Risk Hpv

Context.— Limited data exist on the prevalence of human papillomavirus (HPV)–positive oropharyngeal squamous cell carcinoma in sub-Saharan Africa. Objective.— To determine the prevalence of HPV-positive oropharyngeal squamous cell carcinoma at a large tertiary care center in South Africa. Design.— A total of 266 oropharyngeal squamous cell carcinomas diagnosed during an 11-year period (2007–2017) were selected for evaluation. Cases staining positive for p16 immunohistochemistry were evaluated for high-risk HPV using the BD Onclarity assay (BD Diagnostics, Sparks, Maryland). Results.— Of 266 oropharyngeal squamous cell carcinomas, 14% (n = 36) were positive for p16. Polymerase chain reaction for high-risk HPV performed on the p16-positive cases was negative in 23 cases and positive in 13 cases (13 of 266; 5%). p16 showed a positive predictive value of 36.1%. The HPV subtypes were HPV-16 (n = 10), HPV-18 (n = 1), HPV-52 (n = 1), and HPV-31 (n = 1). Human papillomavirus–positive cases occurred in 10 men and 3 women (mean age, 51 years) and arose from the tonsil (n = 10) or base of the tongue (n = 3). The HPV-positive cases were non-keratinizing (n = 10) or partially keratinizing (n = 1). Partially/nonkeratinizing cases revealed a modest improvement in p16 positive predictive value (11 of 21; 52.4%). Conclusions.— The presence of high-risk HPV in 5% of cases suggests that high-risk HPV is a minor etiologic agent in oropharyngeal squamous cell carcinoma in this region. Given its suboptimal positive predictive value, p16 is not a reliable marker for high-risk HPV infection in this region. When p16 is positive, HPV-specific testing is necessary. The identification of less common high-risk HPV types, HPV-52 and HPV-31, may influence current local vaccination strategies.

Sign in / Sign up

Export Citation Format

Share Document