The novel form of amyloidosis derived from EGF‐containing fibulin‐like extracellular matrix protein 1 (EFEMP1) preferentially affects the lower gastrointestinal tract of elderly females a

2020 ◽  
Author(s):  
Linda N Dao ◽  
Paul J Kurtin ◽  
Thomas C Smyrk ◽  
Jason D Theis ◽  
Surendra Dasari ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Gastrointestinal Tract ◽  
Matrix Protein ◽  
Extracellular Matrix Protein ◽  
The Novel ◽  
Lower Gastrointestinal Tract ◽  
Extracellular Matrix Protein 1

scholarly journals Characterization of the human extracellular matrix protein 1 gene on chromosome 1q21

1997 ◽  
Vol 16 (5) ◽  
pp. 289-292 ◽  
Author(s):  
Maureen R. Johnson ◽  
Douglas J. Wilkin ◽  
Hans L. Vos ◽  
Rosa Isela Ortiz De Luna ◽  
Anindya M. Dehejia ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Matrix Protein ◽  
Extracellular Matrix Protein ◽  
Extracellular Matrix Protein 1 ◽  
Chromosome 1Q21

Extracellular matrix protein 1 (ECM1) is over-expressed in malignant epithelial tumors

2003 ◽  
Vol 200 (1) ◽  
pp. 57-67 ◽  
Author(s):  
Luping Wang ◽  
Jiyao Yu ◽  
Jian Ni ◽  
Xue-Ming Xu ◽  
Jianjin Wang ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Matrix Protein ◽  
Extracellular Matrix Protein ◽  
Epithelial Tumors ◽  
Extracellular Matrix Protein 1

scholarly journals Development of antigen-specific ELISA for circulating autoantibodies to extracellular matrix protein 1 in lichen sclerosus

2004 ◽  
Vol 113 (11) ◽  
pp. 1550-1559 ◽  
Author(s):  
Noritaka Oyama ◽  
Ien Chan ◽  
Sallie M. Neill ◽  
Andrew P. South ◽  
Fenella Wojnarowska ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Matrix Protein ◽  
Lichen Sclerosus ◽  
Extracellular Matrix Protein ◽  
Extracellular Matrix Protein 1 ◽  
Circulating Autoantibodies

scholarly journals Extracellular matrix protein 1 promotes follicular helper T cell differentiation and antibody production

2018 ◽  
Vol 115 (34) ◽  
pp. 8621-8626 ◽  
Author(s):  
Lan He ◽  
Wangpeng Gu ◽  
Meng Wang ◽  
Xiaoyan Chang ◽  
Xiaoyu Sun ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Cell Differentiation ◽  
B Cell ◽  
Antibody Production ◽  
Germinal Center ◽  
Matrix Protein ◽  
Extracellular Matrix Protein ◽  
B Cell Differentiation ◽  
Follicular Helper ◽  
Extracellular Matrix Protein 1

T-follicular helper (TFH) cells are a subset of CD4+ helper T cells that help germinal center (GC) B-cell differentiation and high-affinity antibody production during germinal center reactions. Whether important extracellular molecules control TFH differentiation is not fully understood. Here, we demonstrate that a secreted protein extracellular matrix protein 1 (ECM1) is critical for TFH differentiation and antibody response. A lack of ECM1 inhibited TFH cell development and impaired GC B-cell reactions and antigen-specific antibody production in an antigen-immunized mouse model. ECM1 was induced by IL-6 and IL-21 in TFH cells, promoting TFH differentiation by down-regulating the level of STAT5 phosphorylation and up-regulating Bcl6 expression. Furthermore, injection of recombinant ECM1 protein into mice infected with PR8 influenza virus promoted protective immune responses effectively, by enhancing TFH differentiation and neutralizing antibody production. Collectively, our data identify ECM1 as a soluble protein to promote TFH cell differentiation and antibody production.

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