The diversity of tumours with microsatellite instability: molecular mechanisms and impact upon microsatellite instability testing and mismatch repair protein immunohistochemistry

2020 ◽  
Author(s):  
Jinru Shia
Keyword(s):  
Microsatellite Instability ◽  
Mismatch Repair ◽  
Molecular Mechanisms ◽  
Repair Protein ◽  
Mismatch Repair Protein

scholarly journals Microsatellite instability and mismatch repair protein expressions in lymphocyte‐predominant breast cancer

2020 ◽  
Vol 111 (7) ◽  
pp. 2647-2654 ◽  
Author(s):  
Yoshiya Horimoto ◽  
May Thinzar Hlaing ◽  
Harumi Saeki ◽  
Shigehisa Kitano ◽  
Katsuya Nakai ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Microsatellite Instability ◽  
Mismatch Repair ◽  
Repair Protein ◽  
Protein Expressions ◽  
Mismatch Repair Protein

scholarly journals 32P Comparison of fully automated microsatellite instability test to immunohistochemistry for mismatch repair protein expression in endometrial carcinoma

2020 ◽  
Vol 31 ◽  
pp. S254
Author(s):  
M. Mendiola ◽  
I. Ruz-Caracuel ◽  
V. Heredia Soto ◽  
J.L. Ramón Patiño ◽  
L.E. García de la Calle ◽  
...  
Keyword(s):  
Protein Expression ◽  
Microsatellite Instability ◽  
Endometrial Carcinoma ◽  
Mismatch Repair ◽  
Repair Protein ◽  
Mismatch Repair Protein

scholarly journals Frequency of Mismatch Repair Protein (MMRP) Deficiency among Young Jordanians Diagnosed with Colorectal Carcinoma (CRC)

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Bayan Maraqa ◽  
Ghassan Al-Shbool ◽  
Osama Abu-Shawer ◽  
Mamoun Souleiman ◽  
Osama Alshakhatreh ◽  
...  
Keyword(s):  
Microsatellite Instability ◽  
Mismatch Repair ◽  
Positive Family History ◽  
Young Patients ◽  
Immunohistochemical Analysis ◽  
Cancer Center ◽  
Repair Protein ◽  
Pathologic Features ◽  
Mismatch Repair Protein ◽  
Expression Loss

Purpose. Microsatellite instability (MSI) caused by mismatch repair protein (MMRP) deficiency is detected in 15% of sporadic colorectal cancers (CRCs). Our aim is to investigate the frequency of MMRP deficiency in young CRC patients, using immunohistochemical analysis. Methods. This study targeted cases of CRC at King Hussein Cancer Center from 2004 until 2012 in patients 45 years of age or younger at the time of diagnosis. Clinicopathological data was obtained from 155 patients’ records. Immunohistochemistry for MLH1, MSH2, PMS2, and MSH6 proteins was performed on paraffin-embedded tissue containing carcinoma. Results. The median age of patient at diagnosis was 38 years. A total of 29 (19%) cases showed deficient MMRP(dMMRP)expression. Loss of expression of PMS2 was seen in 17 cases, 12 cases of which showed loss of MLH1 expression. Loss of expression of MSH6 was seen in 10 cases, 9 of which showed loss of MSH2 expression. One case (3.4%) showed loss of all four MMR proteins, and another case (3.4%) showed loss of PMS2/MLH1 and MSH6. There was a significant association between abnormal MMR protein expression and tumor location proximal to splenic flexure (p value 0.000), pathologic features suggestive of microsatellite instability (p value 0.000), P53 negativity (p value 0.000), and stage (p value 0.02). Patients with dMMRP CRC appeared to have a significantly better overall survival compared to patients with proficient MMRP(pMMRP)(p value 0.02). Loss of MSH2/MSH6 was significantly associated with positive family history of cancer (p value = 0.020). Conclusions. The prevalence of dMMRP tumors in this age group appears to be similar to international literature. dMMRP tumors tends to be associated with earlier stages and better outcomes compared to pMMRP cases. dMMRP can serve as a biomarker for better prognosis. These results are of value in directing the clinical management of young patients with CRC.

scholarly journals Microsatellite Instability and DNA Mismatch Repair Protein Deficiency in Lynch Syndrome Colorectal Polyps

2012 ◽  
Vol 5 (4) ◽  
pp. 574-582 ◽  
Author(s):  
Matthew B. Yurgelun ◽  
Ajay Goel ◽  
Jason L. Hornick ◽  
Ananda Sen ◽  
Danielle Kim Turgeon ◽  
...  
Keyword(s):  
Lynch Syndrome ◽  
Microsatellite Instability ◽  
Mismatch Repair ◽  
Dna Mismatch Repair ◽  
Colorectal Polyps ◽  
Protein Deficiency ◽  
Dna Mismatch ◽  
Repair Protein ◽  
Mismatch Repair Protein

scholarly journals No Evidence of Microsatellite Instability and Loss of Mismatch-Repair-Protein Expression in Squamous Cell Carcinoma of the Penis

Pathobiology ◽  
2019 ◽  
Vol 86 (2-3) ◽  
pp. 145-151 ◽  
Author(s):  
Robert Stoehr ◽  
Olaf Wendler ◽  
Johannes Giedl ◽  
Nadine T. Gaisa ◽  
Georg Richter ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Protein Expression ◽  
Microsatellite Instability ◽  
Cell Carcinoma ◽  
Mismatch Repair ◽  
Squamous Cell ◽  
Repair Protein ◽  
Mismatch Repair Protein
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