New insights into the classification of gastric neuroendocrine tumours, expanding the spectrum of ECL‐cell tumours related to hypergastrinaemia

2020 ◽  
Vol 77 (6) ◽  
pp. 862-864
Author(s):  
Stefano La Rosa ◽  
Enrico Solcia
Keyword(s):  
Neuroendocrine Tumours ◽  
Ecl Cell

Gastric neuroendocrine neoplasms and related precursor lesions

2014 ◽  
Vol 67 (11) ◽  
pp. 938-948 ◽  
Author(s):  
Stefano La Rosa ◽  
Alessandro Vanoli
Keyword(s):  
Neuroendocrine Tumours ◽  
Wide Spectrum ◽  
Clinicopathological Features ◽  
Neuroendocrine Neoplasms ◽  
Precursor Lesions ◽  
Comprehensive Overview ◽  
Ecl Cell ◽  
Poorly Differentiated ◽  
Neuroendocrine Carcinomas

Gastric neuroendocrine neoplasms (NENs) are a heterogeneous group of tumours showing different clinicopathological features and behaviour, implying a wide spectrum of therapeutic options. They are currently classified using the 2010 WHO classification of digestive neuroendocrine neoplasms into G1-neuroendocrine tumours (NETs), G2-NETs, neuroendocrine carcinomas (NECs) and mixed adenoneuroendocrine carcinomas (MANECs). However, most gastric NENs are composed of ECL-cells (ECL-cell NETs) that can be preceded by ECL-cell hyperplastic and dysplastic lesions, whose oncologic potential has not yet been completely elucidated. ECL-cell NETs differ considerably in terms of prognosis depending on the proliferative status and clinicopathological background. The integration of both aspects in the diagnostic pathway may help to better classify tumours in different prognostic categories, especially when diagnosing them in small bioptic specimens. NECs are all poorly differentiated, highly aggressive carcinomas, while MANECs can show different morphological features that are directly associated with different prognoses. Precursor lesions of such carcinomas are not entirely understood. In this review, the clinicopathological features of gastric NENs and related precursor lesions will be described to give the reader a comprehensive overview on this topic.

The spectrum and classification of gastric and duodenal neuroendocrine tumours

1995 ◽  
Vol 2 (1) ◽  
pp. 10-14 ◽  
Author(s):  
G. Klöppel ◽  
Ph.U. Heitz ◽  
C. Capella ◽  
E. Solcia
Keyword(s):  
Neuroendocrine Tumours ◽  
Duodenal Neuroendocrine Tumours

scholarly journals Types of Gastric Carcinomas

2018 ◽  
Vol 19 (12) ◽  
pp. 4109 ◽  
Author(s):  
Helge Waldum ◽  
Reidar Fossmark
Keyword(s):  
Gastric Cancer ◽  
Stem Cell ◽  
Gastric Carcinogenesis ◽  
Cell Of Origin ◽  
Gastric Carcinomas ◽  
Ecl Cell ◽  
Cells Of Origin ◽  
Increased Risk

Gastric cancer has reduced prevalence, but poor prognoses. To improve treatment, better knowledge of carcinogenesis and cells of origin should be sought. Stomach cancers are typically localized to one of the three mucosae; cardial, oxyntic and antral. Moreover, not only the stem cell, but the ECL cell may proliferate and give rise to tumours. According to Laurén, the classification of gastric carcinomas seems to reflect biological important differences and possible different cell of origin since the two subtypes, intestinal and diffuse, do not transform into the other and show different epidemiology. The stem cell probably gives rise to the intestinal type, whereas the ECL cell may be important in the diffuse type. Elevation of gastrin may be the carcinogenic factor for Helicobacter pylori as well as the recently described increased risk of gastric cancer due to proton pump inhibitor treatment. Therefore, it is essential to determine the role of the gastrin target cell, the ECL cell, in gastric carcinogenesis. Clinical trials with gastrin antagonists could improve prognoses in those with gastrin receptor positive tumours. However, further studies on gastric carcinomas applying relative available methods and with the highest sensitivity are warranted to improve our knowledge of gastric carcinogenesis.

scholarly journals Is the new WHO classification of neuroendocrine tumours useful for selecting an appropriate treatment?

2005 ◽  
Vol 16 (8) ◽  
pp. 1374-1380 ◽  
Author(s):  
E. Bajetta ◽  
L. Catena ◽  
G. Procopio ◽  
E. Bichisao ◽  
L. Ferrari ◽  
...  
Keyword(s):  
Who Classification ◽  
Neuroendocrine Tumours ◽  
Appropriate Treatment

Revised classification of neuroendocrine tumours of the lung, pancreas and gut

1995 ◽  
Vol 425 (6) ◽  
Author(s):  
C. Capella ◽  
P.U. Heitz ◽  
H. H�fler ◽  
E. Solcia ◽  
G. Kl�ppel
Keyword(s):  
Neuroendocrine Tumours
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