Histopathological evaluation of minor salivary gland papillary–cystic tumours: focus on genetic alterations in sialadenoma papilliferum and intraductal papillary mucinous neoplasm

2019 ◽  
Vol 76 (3) ◽  
pp. 411-422 ◽  
Author(s):  
Masato Nakaguro ◽  
Makoto Urano ◽  
Ikuko Ogawa ◽  
Hideaki Hirai ◽  
Yoshinari Yamamoto ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Intraductal Papillary Mucinous Neoplasm ◽  
Minor Salivary Gland ◽  
Genetic Alterations ◽  
Mucinous Neoplasm ◽  
Histopathological Evaluation ◽  
Sialadenoma Papilliferum

scholarly journals Case report: composite pancreatic intraductal papillary mucinous neoplasm and neuroendocrine tumor: a new mixed neuroendocrine-non-neuroendocrine neoplasm?

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Jingci Chen ◽  
Pengyan Wang ◽  
Ke Lv ◽  
Weixun Zhou
Keyword(s):  
Neuroendocrine Tumor ◽  
Intraductal Papillary Mucinous Neoplasm ◽  
Histopathological Examination ◽  
Abdominal Ultrasound ◽  
Genetic Alterations ◽  
Neuroendocrine Neoplasm ◽  
Neuroendocrine Neoplasms ◽  
Pancreatic Lesion ◽  
Partial Pancreatectomy ◽  
Mucinous Neoplasm

Abstract Background Mixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN) of the pancreas are extremely rare. Their pathogenesis and molecular landscape are largely unknown. Here, we report a case of mixed pancreatic intraductal papillary mucinous neoplasm (IPMN) and well-differentiated neuroendocrine tumor (NET) and identify its genetic alterations by next-generation sequencing (NGS). Case presentation A fifty-year-old male was admitted into the hospital for evaluation of a pancreatic lesion detected during a routine examination. Abdominal ultrasound indicated a hypoechoic mass of 2.6 cm at the head of the pancreas. Malignancy was suspected and partial pancreatectomy was performed. Thorough histopathological examination revealed a mixed IPMN-NET. In some areas, the two components were relatively separated, whereas in other areas IPMN and NET grew in a composite pattern: The papillae were lined with epithelial cells of IPMN, and there were clusters of NET nests in the stroma of papillary axis. NGS revealed shared somatic mutations (KRAS, PCK1, MLL3) in both components. The patient has been uneventful 21 months after the surgery. Conclusions Our case provides evidence of a common origin for mixed IPMN-NET with composite growth features. Our result and literature review indicate that KRAS mutation might be a driver event underlying the occurrence of MiNEN. We also recommend the inclusion of mixed non-invasive exocrine neoplasms and neuroendocrine neoplasms into MiNEN.

Sialadenoma papilliferum of the bronchus: rare tracheobronchial tumor of salivary gland type

Pneumologie ◽  
2011 ◽  
Vol 65 (S 01) ◽  
Author(s):  
RF Falkenstern-Ge ◽  
G Ott ◽  
G Friedel ◽  
H Markmann ◽  
J Kalla ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Sialadenoma Papilliferum ◽  
Gland Type

Multimodality Treatment and Survival in Sinonasal Minor Salivary Gland Tumors

2019 ◽  
Author(s):  
Sina Torabi ◽  
Todd Spock ◽  
Bruno Cardoso ◽  
Janet Chao ◽  
R. Manes ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Minor Salivary Gland ◽  
Multimodality Treatment ◽  
Salivary Gland Tumors ◽  
Minor Salivary Gland Tumors
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