High-grade PanIN presenting with localised stricture of the main pancreatic duct: A clinicopathological and molecular study of 10 cases suggests a clue for the early detection of pancreatic cancer

2018 ◽  
Vol 73 (2) ◽  
pp. 247-258 ◽  
Author(s):  
Masataka Yokode ◽  
Masayuki Akita ◽  
Kohei Fujikura ◽  
Mi-Ju Kim ◽  
Yukiko Morinaga ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Early Detection ◽  
Pancreatic Duct ◽  
Main Pancreatic Duct ◽  
Molecular Study ◽  
High Grade

scholarly journals Predictive Value of Localized Stenosis of the Main Pancreatic Duct for Early Detection of Pancreatic Cancer

2019 ◽  
Vol 52 (6) ◽  
pp. 588-597 ◽  
Author(s):  
Yoshihide Kanno ◽  
Shinsuke Koshita ◽  
Takahisa Ogawa ◽  
Hiroaki Kusunose ◽  
Kaori Masu ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Early Detection ◽  
Pancreatic Duct ◽  
Predictive Value ◽  
Main Pancreatic Duct ◽  
Localized Stenosis

Main pancreatic duct dilation above 6 mm and supraliminal preoperative Ca19.9 levels increase the risk for high grade dysplasia and cancer in IPMN patients

Pancreatology ◽  
2017 ◽  
Vol 17 (4) ◽  
pp. S47
Author(s):  
Roberto Valente ◽  
Zeeshan Ateeb ◽  
Yasmine Schlieper ◽  
Raffaella Pozzi Mucelli ◽  
Ann Morgell ◽  
...  
Keyword(s):  
Pancreatic Duct ◽  
Main Pancreatic Duct ◽  
High Grade Dysplasia ◽  
High Grade

scholarly journals A Case of Pancreatic Intraepithelial Neoplasia That Was Difficult to Diagnose Preoperatively

2015 ◽  
Vol 8 (1) ◽  
pp. 30-36 ◽  
Author(s):  
Hiroyuki Ito ◽  
Yoshiaki Kawaguchi ◽  
Yohei Kawashima ◽  
Atsuko Maruno ◽  
Masami Ogawa ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Pancreatic Duct ◽  
Main Pancreatic Duct ◽  
Cystic Lesion ◽  
Precancerous Lesion ◽  
Intraepithelial Neoplasia ◽  
The Body ◽  
Pancreatic Ductal Carcinoma ◽  
Pancreatic Intraepithelial Neoplasia ◽  
Multiple Imaging

A 63-year-old female patient presented to a local physician with pain in her back and epigastric region. An abdominal computed tomography (CT) scan revealed a pancreatic tumor, and the patient was referred to our hospital. Multiple imaging studies that included ultrasonography (US), CT, MRI, and endoscopic US revealed a cystic lesion 3-4 cm in size with node-like projections in the body of the pancreas. The distal main pancreatic duct was also found to be dilated. Endoscopic retrograde pancreatography revealed an irregular stenosis of the main pancreatic duct proximal to the cystic lesion, and malignancy was suspected. The patient was preoperatively diagnosed with pancreatic ductal carcinoma concomitant with intraductal papillary mucinous carcinoma, and a distal pancreatectomy was performed. Rapid pathological diagnosis during surgery revealed positive surgical margins for pancreatic intraepithelial neoplasia (PanIN). Further resection was performed twice, her surgical margin was positive and total pancreatectomy was ultimately conducted. Histopathological findings revealed diffuse microinvasive cancerous lesions corresponding to PanIN-2 (moderate dysplasia) to PanIN-3 (carcinoma in situ) throughout the pancreas. PanIN involves microlesions of the ductal epithelium that may precede pancreatic cancer. Ascertaining changes in PanIN using images provided by diagnostic modalities such as CT and US is challenging. Ductal stenosis and distal cystic lesions resulting from atrophy and fibrosis of pancreatic tissue were noted around PanIN. Considering the possibility of PanIN, a precancerous lesion during differential diagnosis will help to improve early detection and prognosis for patients with pancreatic cancer.

scholarly journals Focal Parenchymal Atrophy and Fat Replacement Are Clues for Early Diagnosis of Pancreatic Cancer with Abnormalities of the Main Pancreatic Duct

2020 ◽  
Vol 252 (1) ◽  
pp. 63-71
Author(s):  
Shin Miura ◽  
Kiyoshi Kume ◽  
Kazuhiro Kikuta ◽  
Shin Hamada ◽  
Tetsuya Takikawa ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Early Diagnosis ◽  
Pancreatic Duct ◽  
Main Pancreatic Duct ◽  
Fat Replacement

Main pancreatic duct dilation greater than 6 mm is associated with an increased risk of high-grade dysplasia and cancer in IPMN patients

2019 ◽  
Vol 404 (1) ◽  
pp. 31-37 ◽  
Author(s):  
Zeeshan Ateeb ◽  
Roberto Valente ◽  
Raffaella M. Pozzi-Mucelli ◽  
Linnéa Malgerud ◽  
Yasmine Schlieper ◽  
...  
Keyword(s):  
Pancreatic Duct ◽  
Main Pancreatic Duct ◽  
High Grade Dysplasia ◽  
High Grade ◽  
Increased Risk

scholarly journals Partial Pancreatic Parenchymal Atrophy Is a New Specific Finding to Diagnose Small Pancreatic Cancer (≤10 mm) Including Carcinoma in Situ: Comparison with Localized Benign Main Pancreatic Duct Stenosis Patients

Diagnostics ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 445
Author(s):  
Kentaro Yamao ◽  
Mamoru Takenaka ◽  
Rei Ishikawa ◽  
Ayana Okamoto ◽  
Tomohiro Yamazaki ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Pancreatic Duct ◽  
Carcinoma In Situ ◽  
Main Pancreatic Duct ◽  
Final Analysis ◽  
Kappa Statistics ◽  
Pancreatic Parenchyma ◽  
Ct Findings ◽  
Small Pancreatic Cancer

Background: This study aimed to evaluate and identify the specific CT findings by focusing on abnormalities in the main pancreatic duct (MPD) and pancreatic parenchyma in patients with small pancreatic cancer (PC) including carcinoma in situ (CIS). Methods: Nine CT findings indicating abnormalities of MPD and pancreatic parenchyma were selected as candidate findings for the presence of small PC ≤ 10 mm. The proportions of patients positive for each finding were compared between small PC and benign MPD stenosis groups. Interobserver agreement between two independent image reviewers was evaluated using kappa statistics. Results: The final analysis included 24 patients with small PC (including 11 CIS patients) and 28 patients with benign MPD stenosis. The proportion of patients exhibiting partial pancreatic parenchymal atrophy (PPA) corresponding to the distribution of MPD stenosis (45.8% vs. 7.1%, p < 0.01), upstream PPA arising from the site of MPD stenosis (33.3% vs. 3.6%, p = 0.01), and MPD abrupt stenosis (45.8% vs. 14.3%, p = 0.03) was significantly higher in the small PC group than in the benign MPD stenosis group. Conclusions: The presence of partial PPA, upstream PPA, and MPD abrupt stenosis on a CT image was highly suggestive of the presence of small PCs including CIS.

scholarly journals Efficacy of brush cytology of the main pancreatic duct and biliary duct in the diagnosis of pancreatic cancer

2004 ◽  
Vol 65 (2) ◽  
pp. 47-50
Author(s):  
Takayuki Aimoto ◽  
Takashi Tajiri ◽  
Eiji Uchida ◽  
Yoshiharu Nakamura ◽  
Akira Katsuno ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Pancreatic Duct ◽  
Main Pancreatic Duct ◽  
Biliary Duct ◽  
Brush Cytology
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