scholarly journals Hepatic elastin content is predictive of adverse outcome in advanced fibrotic liver disease

2018 ◽  
Vol 73 (1) ◽  
pp. 90-100 ◽  
Author(s):  
Timothy J Kendall ◽  
Grace E Dolman ◽  
Catherine M Duff ◽  
Emma C Paish ◽  
Abed Zaitoun ◽  
...  
Keyword(s):  
Liver Disease ◽  
Adverse Outcome ◽  
Fibrotic Liver ◽  
Fibrotic Liver Disease

Evaluation of Fibrotic Liver Disease with Whole-Liver T1ρ MR Imaging: A Feasibility Study at 1.5 T

Radiology ◽  
2014 ◽  
Vol 271 (2) ◽  
pp. 408-415 ◽  
Author(s):  
Thomas Allkemper ◽  
Florian Sagmeister ◽  
Vito Cicinnati ◽  
Susanne Beckebaum ◽  
Hendrik Kooijman ◽  
...  
Keyword(s):  
Liver Disease ◽  
Mr Imaging ◽  
Feasibility Study ◽  
Fibrotic Liver ◽  
Fibrotic Liver Disease

Latest developments in the imaging of fibrotic liver disease

2014 ◽  
Vol 55 (7) ◽  
pp. 802-813 ◽  
Author(s):  
Minal J Sangwaiya ◽  
David IN Sherman ◽  
David J Lomas ◽  
Philip J Shorvon
Keyword(s):  
Liver Disease ◽  
Fibrotic Liver ◽  
Fibrotic Liver Disease

MicroRNA-21 is associated with fibrosis in a rat model of nonalcoholic steatohepatitis and serves as a plasma biomarker for fibrotic liver disease

2016 ◽  
Vol 258 ◽  
pp. 159-167 ◽  
Author(s):  
Ayano Takeuchi-Yorimoto ◽  
Yu Yamaura ◽  
Masayuki Kanki ◽  
Tetsuya Ide ◽  
Ayumi Nakata ◽  
...  
Keyword(s):  
Liver Disease ◽  
Rat Model ◽  
Nonalcoholic Steatohepatitis ◽  
Plasma Biomarker ◽  
Fibrotic Liver ◽  
Fibrotic Liver Disease

760 vFLIP, a Viral Regulator of Caspase-8 Induces Acute Death Mediated Liver Damage That Promotes Chronic Fibrotic Liver Disease

2014 ◽  
Vol 146 (5) ◽  
pp. S-925
Author(s):  
Claudia Günther ◽  
Stefan J. Wirtz ◽  
Markus F. Neurath ◽  
Helmut Neumann ◽  
Christoph Becker
Keyword(s):  
Liver Disease ◽  
Liver Damage ◽  
Caspase 8 ◽  
Fibrotic Liver ◽  
Fibrotic Liver Disease

scholarly journals Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives

Cells ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 875 ◽  
Author(s):  
Natascha Roehlen ◽  
Emilie Crouchet ◽  
Thomas F. Baumert
Keyword(s):  
Liver Disease ◽  
Liver Fibrosis ◽  
Disease Progression ◽  
Liver Diseases ◽  
Chronic Liver ◽  
Specific Cell ◽  
Chronic Liver Diseases ◽  
Fibrotic Liver ◽  
Liver Disease Progression ◽  
Fibrotic Liver Disease

Liver fibrosis due to viral or metabolic chronic liver diseases is a major challenge of global health. Correlating with liver disease progression, fibrosis is a key factor for liver disease outcome and risk of hepatocellular carcinoma (HCC). Despite different mechanism of primary liver injury and disease-specific cell responses, the progression of fibrotic liver disease follows shared patterns across the main liver disease etiologies. Scientific discoveries within the last decade have transformed the understanding of the mechanisms of liver fibrosis. Removal or elimination of the causative agent such as control or cure of viral infection has shown that liver fibrosis is reversible. However, reversal often occurs too slowly or too infrequent to avoid life-threatening complications particularly in advanced fibrosis. Thus, there is a huge unmet medical need for anti-fibrotic therapies to prevent liver disease progression and HCC development. However, while many anti-fibrotic candidate agents have shown robust effects in experimental animal models, their anti-fibrotic effects in clinical trials have been limited or absent. Thus, no approved therapy exists for liver fibrosis. In this review we summarize cellular drivers and molecular mechanisms of fibrogenesis in chronic liver diseases and discuss their impact for the development of urgently needed anti-fibrotic therapies.

scholarly journals Interaction of TWEAK with Fn14 leads to the progression of fibrotic liver disease by directly modulating hepatic stellate cell proliferation

2016 ◽  
Vol 239 (1) ◽  
pp. 109-121 ◽  
Author(s):  
Annika Wilhelm ◽  
Emma L Shepherd ◽  
Aldo Amatucci ◽  
Mamoona Munir ◽  
Gary Reynolds ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Liver Disease ◽  
Hepatic Stellate Cell ◽  
Stellate Cell ◽  
Fibrotic Liver ◽  
Fibrotic Liver Disease

Assessment of fibrotic liver disease with multimodal nonlinear optical microscopy

2010 ◽  
Author(s):  
Fake Lu ◽  
Wei Zheng ◽  
Dean C. S. Tai ◽  
Jian Lin ◽  
Hanry Yu ◽  
...  
Keyword(s):  
Liver Disease ◽  
Optical Microscopy ◽  
Nonlinear Optical ◽  
Nonlinear Optical Microscopy ◽  
Fibrotic Liver ◽  
Fibrotic Liver Disease
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