scholarly journals Punch ‘scoring’: a technique that facilitates melanoma diagnosis of clinically suspicious pigmented lesions

2017 ◽  
Vol 72 (2) ◽  
pp. 294-304 ◽  
Author(s):  
Judith Grogan ◽  
Caroline L Cooper ◽  
Tristan J Dodds ◽  
Pascale Guitera ◽  
Scott W Menzies ◽  
...  
Keyword(s):  
Pigmented Lesions ◽  
Melanoma Diagnosis

scholarly journals Dermatofluoroscopy Is Also for Redheads a Sensitive Method of Early Melanoma Detection

Dermatology ◽  
2020 ◽  
Vol 236 (6) ◽  
pp. 508-516
Author(s):  
Dieter Leupold ◽  
Lukasz Szyc ◽  
Goran Stankovic ◽  
Maja Hofmann ◽  
Matthias Scholz ◽  
...  
Keyword(s):  
Fluorescence Spectra ◽  
Spectral Characteristics ◽  
Spatially Resolved ◽  
Melanoma Detection ◽  
Dysplastic Nevi ◽  
Red Hair ◽  
Pigmented Lesions ◽  
Melanoma Diagnosis ◽  
Increased Risk ◽  
Hair Samples

<b><i>Background:</i></b> Caucasians with red hair and fair skin have a remarkably increased risk of malignant melanoma compared to non-redhead Caucasians. <b><i>Objectives:</i></b> With the aim of a reliable melanoma diagnosis in redheads, the application of dermatofluoroscopy was analyzed in 16 patients with red hair. Most of them had been included in a clinical dermatofluoroscopy study for patients with the suspicion of melanoma. We examined whether the 25 lesions of the redheads showed the same characteristic melanin fluorescence spectra for dysplastic nevi and melanomas as those of non-redhead Caucasians or whether there was a different fluorescence pattern. This is important in view of the known significantly altered ratio of eumelanin to pheomelanin in the skin of redheads. <b><i>Methods:</i></b> More than 8,000 spatially resolved fluorescence spectra of 25 pigmented lesions were measured and analysed. The spectra were excited by the stepwise absorption of two 800-nm photons (principle of dermatofluoroscopy). Furthermore, the fluorescence spectra of eumelanin and pheomelanin in hair samples were determined in the same way. <b><i>Results:</i></b> The evaluation revealed that the melanin fluorescence spectra of dysplastic nevi and melanomas of redheads have the same spectral characteristics as those of non-redhead Caucasians. An accompanying result is that dermatofluoroscopy shows identical fluorescence spectra for eumelanin and pheomelanin. <b><i>Conclusions:</i></b> Dermatofluoroscopy proves to be a reliable diagnostic method also for redheads. Our results also explain our recent finding that there is a uniform fluorescence spectroscopic fingerprint for melanomas of all subtypes, which is of particular interest for hypomelanotic and apparently amelanotic melanomas containing pheomelanin.

Subungueal pigmented lesions: warning for dermoscopic melanoma diagnosis

2011 ◽  
Vol 21 (2) ◽  
pp. 286-287 ◽  
Author(s):  
Marta GRAZZINI ◽  
Susanna ROSSARI ◽  
Alessia GORI ◽  
Suzanna CORCIOVA ◽  
Giuseppe GUERRIERO ◽  
...  
Keyword(s):  
Pigmented Lesions ◽  
Melanoma Diagnosis

scholarly journals General practitioner screening for melanoma: sensitivity, specificity, and effect of training

1998 ◽  
Vol 5 (3) ◽  
pp. 156-161 ◽  
Author(s):  
R C Burton ◽  
C Howe ◽  
L Adamson ◽  
A L Reid ◽  
P Hersey ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Histopathological Examination ◽  
Cost Effective ◽  
Predictive Values ◽  
Men And Women ◽  
Pigmented Lesions ◽  
Melanoma Diagnosis ◽  
Cancer Specialists ◽  
Sensitivity Specificity ◽  
The Cost

Objective To measure the performance of trained and untrained general practitioners (GPs) in screening men and women aged 50 or more for melanomas. Methods GPs trained in melanoma diagnosis, untrained GPs, and skin cancer specialists examined groups of volunteers, each of which included a small number of subjects with prediagnosed suspicious pigmented lesions (SPLs) that were subsequently excised for histopathological examination. Results Trained and untrained GPs achieved mean sensitivities of 0.73 and 0.71, and mean predictive values of 0.40 and 0.37, respectively, for the detection of prediagnosed SPLs. When the SPLs had been excised and examined histopathologically, reanalysis showed mean sensitivities of 0.98 and 0.95, mean specificities of 0.52 and 0.49, and mean positive predictive values of 0.24 and 0.22 for the detection of subjects with melanomas by trained and untrained GPs respectively. Trained GPs were significantly better than untrained GPs at diagnosing as melanomas SPLs that subsequently proved to be melanomas (p=0.04). Conclusions GPs in this study achieved high sensitivities in screening older Australian men and women for melanomas, but at the cost of low specificities and positive predictive values. Training in melanoma diagnosis had no significant effect on sensitivity, specificity, and positive predictive value for screening. Data from the study were tested in a model of population screening for melanomas, and costs per life year saved for men aged 50–70 ranged from &dollar;A11 852 to &dollar;A40 259 depending upon the screening interval and whether the GPs excised the SPLs diagnosed, or referred all patients to skin cancer specialists; this would be as cost effective as cervical cancer screening.

scholarly journals Assessment of Raman Spectroscopy for Reducing Unnecessary Biopsies for Melanoma Screening

Molecules ◽  
2020 ◽  
Vol 25 (12) ◽  
pp. 2852 ◽  
Author(s):  
Yao Zhang ◽  
Austin J. Moy ◽  
Xu Feng ◽  
Hieu T. M. Nguyen ◽  
Katherine R. Sebastian ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Principal Component ◽  
Number Needed To Treat ◽  
Logistic Regression Models ◽  
Pigmented Lesions ◽  
Melanoma Diagnosis ◽  
Significant Step ◽  
Raman Spectral Data ◽  
Melanoma Screening

A key challenge in melanoma diagnosis is the large number of unnecessary biopsies on benign nevi, which requires significant amounts of time and money. To reduce unnecessary biopsies while still accurately detecting melanoma lesions, we propose using Raman spectroscopy as a non-invasive, fast, and inexpensive method for generating a “second opinion” for lesions being considered for biopsy. We collected in vivo Raman spectral data in the clinical skin screening setting from 52 patients, including 53 pigmented lesions and 7 melanomas. All lesions underwent biopsies based on clinical evaluation. Principal component analysis and logistic regression models with leave one lesion out cross validation were applied to classify melanoma and pigmented lesions for biopsy recommendations. Our model achieved an area under the receiver operating characteristic (ROC) curve (AUROC) of 0.903 and a specificity of 58.5% at perfect sensitivity. The number needed to treat for melanoma could have been decreased from 8.6 (60/7) to 4.1 (29/7). This study in a clinical skin screening setting shows the potential of Raman spectroscopy for reducing unnecessary skin biopsies with in vivo Raman data and is a significant step toward the application of Raman spectroscopy for melanoma screening in the clinic.

Birth marks and neonatal skin disorders. From angel kiss to epidermolysis bullosa

2014 ◽  
Vol 155 (13) ◽  
pp. 500-508 ◽  
Author(s):  
Zsanett Csoma ◽  
Angéla Meszes ◽  
Rita Ábrahám ◽  
Judit Bakki ◽  
Zita Gyurkovits ◽  
...  
Keyword(s):  
Newborn Infants ◽  
Vascular Lesions ◽  
Whole Body ◽  
Special Treatment ◽  
Skin Disorders ◽  
Cutaneous Lesions ◽  
Developmental Abnormalities ◽  
Pigmented Lesions ◽  
Mongolian Spot ◽  
Neonatal Skin

Introduction: At present there are no exact epidemiologic data on the prevalence of neonatal skin disorders and birth marks in Hungary. Aim: The aim of the authors was to investigate the prevalence of skin disorders in mature healthy neonates after birth. Method: The survey was carried out in the Neonatal Care Unit at the Department of Obstetrics and Gynaecology at the University of Szeged between April, 2012 and May, 2013. Results:A total of 2289 newborn infants underwent whole-body screening skin examinations. At least one skin manifestation was found in 63% of the neonates. The major groups of skin disorders were transient benign cutaneous lesions, vascular lesions, pigmented lesions, traumatic, iatrogenic, congenital or acquired disorders with skin injuries, developmental abnormalities and benign skin tumours. The most frequent transient cutaneous lesions were erythema toxicum neonatorum, sebaceous hyperplasia and desquamation. The most common vascular lesions were naevus simplex, haemangioma and haemangioma precursor lesion, while the most frequently observed pigmented lesions were congenital melanocytic naevi and Mongolian spot. Conclusions: In the vast majority of cases, special treatment was not necessary, but 5.27% of the neonates required local dermatologic therapy, and in 9.2% of neonates follow up was recommended. Orv. Hetil., 2014, 155(13), 500–508.

Sequential monitoring of pigmented lesions during dabrafenib treatment: a prospective study and a literature overview

2019 ◽  
Vol 154 (2) ◽  
Author(s):  
Emi Dika ◽  
Martina Lambertini ◽  
Pier A. Fanti ◽  
Bianca M. Piraccini ◽  
Carlotta Gurioli ◽  
...  
Keyword(s):  
Prospective Study ◽  
Pigmented Lesions ◽  
Literature Overview ◽  
A Prospective Study

Treatment of Epidermal Pigmented Lesions with 578 nm Yellow Laser

2015 ◽  
Vol 4 (1) ◽  
pp. 35-38 ◽  
Author(s):  
Suhyun Cho ◽  
Yoon Jin Choi ◽  
Jin-Soo Kang
Keyword(s):  
Pigmented Lesions ◽  
Yellow Laser
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