Prominent neural invasion of mucosal gastric cancer into the muscularis propria

2017 ◽  
Vol 71 (4) ◽  
pp. 661-662 ◽  
Author(s):  
Young-Bae Kim ◽  
Sang-Uk Han ◽  
Dakeun Lee
Keyword(s):  
Gastric Cancer ◽  
Muscularis Propria ◽  
Neural Invasion ◽  
Mucosal Gastric Cancer

scholarly journals A semi-pedunculated mucosal gastric cancer of 0-I type with remarkable lymph follicle formation in the mucosal muscle layer

2001 ◽  
Vol 59 (2) ◽  
pp. 86-87
Author(s):  
Naomi Kakushima ◽  
Mitsuhiro Fujishiro ◽  
Naohisa Yahagi ◽  
Shotaro Enomoto ◽  
Ayako Tateishi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Muscle Layer ◽  
Lymph Follicle ◽  
Mucosal Gastric Cancer

Extramural venous invasion detected by MDCT as an adverse imaging feature for predicting synchronous metastases in T4 gastric cancer

2016 ◽  
Vol 58 (4) ◽  
pp. 387-393 ◽  
Author(s):  
Jin Cheng ◽  
Jing Wu ◽  
Yingjiang Ye ◽  
Chunfang Zhang ◽  
Yinli Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Muscularis Propria ◽  
Venous Invasion ◽  
Distant Metastases ◽  
Imaging Feature ◽  
Contrast Enhanced ◽  
Postoperative Diagnosis ◽  
Mesenteric Vessels ◽  
Synchronous Metastases ◽  
T4 Gastric Cancer

Background Extramural venous invasion (EMVI) is defined histologically as the active invasion of tumor cells to the lumens of mesenteric vessels beyond the muscularis propria in advanced gastrointestinal cancer, resulting in distant metastases. Purpose To determine the association between synchronous metastatic disease in patients with T4 gastric cancer and EMVI detected on contrast-enhanced multiple-row detector computed tomography (MDCT). Material and Methods A total of 152 patients with T4 gastric carcinoma were retrospectively reviewed and divided into EMVI-positive and EMVI-negative groups where EMVI, as detected on MDCT, was defined as a tubular or nodular soft tissue thickening extending from the tumor along the vessels of the mesentery. Synchronous metastases were detected by MDCT and/or confirmed by postoperative diagnosis. Logistic regression analyses were performed to analyze the predictive factors of synchronous metastases in gastric cancer. Results Synchronous metastases were found in 47 of 152 (30.9%) patients with T4 gastric cancer. Thirty-one of 77 (40.3%) patients in the EMVI-positive group had evidence of metastases compared to 16 (21.3%) of 75 patients in the EMVI-negative group ( P = 0.019). Synchronous metastases were significantly associated with EMVI with an odds ratio (OR) of 2.250 (95% CI, 1.072–4.724). Conclusion EMVI-positive tumors, as an adverse imaging feature, were significantly associated with synchronous metastases in patients with T4 gastric cancer.

Mucin phenotype and narrow-band imaging with magnifying endoscopy for differentiated-type mucosal gastric cancer

2011 ◽  
Vol 46 (9) ◽  
pp. 1064-1070 ◽  
Author(s):  
Masaaki Kobayashi ◽  
Manabu Takeuchi ◽  
Yoichi Ajioka ◽  
Satoru Hashimoto ◽  
Akito Sato ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Magnifying Endoscopy ◽  
Mucin Phenotype ◽  
Mucosal Gastric Cancer

scholarly journals A Clicopathological Study of Lymph Node Positive Intra Mucosal Gastric Cancer.

1995 ◽  
Vol 28 (4) ◽  
pp. 766-771
Author(s):  
Tatsuhiko Hayashi ◽  
Atsushi Nashimoto ◽  
Otsuo Tanaka ◽  
Juei Sasaki
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Node Positive ◽  
Mucosal Gastric Cancer ◽  
Lymph Node Positive

scholarly journals Netrin-1 promotes cell neural invasion in gastric cancer via its receptor neogenin

2019 ◽  
Vol 10 (14) ◽  
pp. 3197-3207
Author(s):  
Kai Yin ◽  
Linjun Wang ◽  
Yiwen Xia ◽  
Shengchun Dang ◽  
Xuan Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Neural Invasion

Prognostic value of subclassification of pT2 stage in patients with gastric cancer.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e16070-e16070
Author(s):  
Kang He ◽  
Xiaohua Wang ◽  
Cheng Chen ◽  
Yingying Jiang ◽  
Yue Shi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Adjuvant Chemotherapy ◽  
Tumor Invasion ◽  
Radical Surgery ◽  
Muscularis Propria ◽  
Staging System ◽  
Tnm Staging ◽  
Tnm Staging System ◽  
Pn Stage ◽  
Better Than

e16070 Background: The data about prognosis difference of patients with pT2 stage gastric cancer (GC) after radical surgery is diverse. The latest TNM staging system does not define details for the pT2 stage subclassification. The purpose of this study is to investigate the survival difference according to depth of tumor muscularis propria involvement and find biomarker to reinforce the prognostic and therapy-guided ability of TNM staging system. Methods: A total of 380 patients with pT2 GC after radical surgery were retrospectively analyzed, including 185 in sMP (superficial muscularis propria) group and 195 in dMP (deep muscularis propria) group. The log-rank test was used to identify survival outcomes. Independent factors were identified by multivariable Cox proportional hazard model for OS. Results: The overall survival (OS) of patients in sMP group was significantly better than patients in dMP group (P = 0.007). On multivariate analysis, age (＜60 vs ≥60: P = 0.004, HR, 2.075(95%CI: 1.261-3.414)), primary location (P = 0.002, U vs M: 0.985(0.509-1.909); U vs L: 0.400(0.235-0.680)), depth of tumor invasion (sMP vs dMP: P = 0.050, 1.584(1.261-3.414), pN stage (P = 0.000, N0 vs N1: 2.304(1.364-3.890); N0 vs N2: 1.879(0.967-3.652); N0 vs N3: 5.335(2.533-11.237)), expression of p53 (negative vs positive: P = 0.016, 1.793(1.117-2.879)) were independent prognostic factors for the OS. In pN0 stage tumor, the sMP group had a significantly better OS than the dMP group (P = 0.014). When classified as N+, there was no obviously difference of OS between two groups (P = 0.384). When patients were stratified according to the depth of tumor invasion and pN stage, the OS was not significant difference between dMPN0 group and sMPN1-2 group (P = 0.100), the OS of patients with adjuvant chemotherapy were statistically better than those without in dMPN0 group (P = 0.045), but not significance in sMPN1-2 group (P = 0.486). After further grouping according to adjuvant chemotherapy status, in comparison to sMPN1-2 patients, dMPN0 patients with adjuvant chemotherapy had better OS (P = 0.015), but not significance in patients without (P = 0.599). Upon stratification according to the expression of p53, in p53-positive group, greater OS could be observed in patients with sMPN0 than patients with dMPN0 (P = 0.002). Similar OS could be seen between dMPN0 patients with p53-positive and T2N1-2 patients (P = 0.872). Conclusions: For pT2 gastric cancer patients, there were differences in survival outcomes for sMP and dMP invasion. The prognosis of dMPN0 patients were similar to patients with sMPN1-2, and dMPN0 patients who accepted adjuvant chemotherapy had an improved prognosis than those without. Appropriate adjuvant chemotherapy should be considered for patients with dMPN0 stage. In addition, positive expression of p53 could be potential factors to identify the different prognoses for patients with pT2 gastric cancers.

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