H3F3A mutation in giant cell tumour of the bone is detected by immunohistochemistry using a monoclonal antibody against the G34W mutated site of the histone H3.3 variant

2017 ◽  
Vol 71 (1) ◽  
pp. 125-133 ◽  
Author(s):  
Julian Lüke ◽  
Alexandra von Baer ◽  
Jordan Schreiber ◽  
Christoph Lübbehüsen ◽  
Thomas Breining ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Giant Cell ◽  
Giant Cell Tumour ◽  
Cell Tumour ◽  
Histone H3.3 ◽  
H3f3a Mutation

scholarly journals Cell Biology of Giant Cell Tumour of Bone: Crosstalk between m/wt Nucleosome H3.3, Telomeres and Osteoclastogenesis

Cancers ◽  
2021 ◽  
Vol 13 (20) ◽  
pp. 5119
Author(s):  
Ramses G. Forsyth ◽  
Tibor Krenács ◽  
Nicholas Athanasou ◽  
Pancras C. W. Hogendoorn
Keyword(s):  
Giant Cell ◽  
Genomic Instability ◽  
Cell Biology ◽  
Giant Cell Tumour ◽  
Lung Metastases ◽  
Relevant Literature ◽  
Cell Tumour ◽  
High Tendency ◽  
Molecular Features ◽  
Histone H3.3

Giant cell tumour of bone (GCTB) is a rare and intriguing primary bone neoplasm. Worrisome clinical features are its local destructive behaviour, its high tendency to recur after surgical therapy and its ability to create so-called benign lung metastases (lung ‘plugs’). GCTB displays a complex and difficult-to-understand cell biological behaviour because of its heterogenous morphology. Recently, a driver mutation in histone H3.3 was found. This mutation is highly conserved in GCTB but can also be detected in glioblastoma. Denosumab was recently introduced as an extra option of medical treatment next to traditional surgical and in rare cases, radiotherapy. Despite these new insights, many ‘old’ questions about the key features of GCTB remain unanswered, such as the presence of telomeric associations (TAs), the reactivation of hTERT, and its slight genomic instability. This review summarises the recent relevant literature of histone H3.3 in relation to the GCTB-specific G34W mutation and pays specific attention to the G34W mutation in relation to the development of TAs, genomic instability, and the characteristic morphology of GCTB. As pieces of an etiogenetic puzzle, this review tries fitting all these molecular features and the unique H3.3 G34W mutation together in GCTB.

scholarly journals The current standing on the use of denosumab in giant cell tumour of the bone

2020 ◽  
Vol 28 (3) ◽  
pp. 230949902097975
Author(s):  
Vivek Ajit Singh ◽  
Ajay Puri
Keyword(s):  
Monoclonal Antibody ◽  
Targeted Therapy ◽  
Giant Cell ◽  
Giant Cell Tumour ◽  
Cell Tumour ◽  
Adjuvant Setting ◽  
Long Term Effects ◽  
Current Recommendation ◽  
And Control

Giant cell tumour of the bone (GCTB) has been classically treated surgically. With the advent of denosumab, there is potential to use it as a targeted therapy to downstage the tumour and control its progression. Like all new therapies, the dosage, duration, and long-term effects of treatment can only be determined over the time through numerous trials and errors. The current recommendation of use of the monoclonal antibody is 3–4 months of neoadjuvant denosumab in patients with advanced GCTB for cases who were not candidates for primary curettage initially, and prolonged use for surgically unsalvageable GCTB. The use of Denosumab in the adjuvant setting to prevent recurrence is not established.

scholarly journals AB0049 Rheumatoid arthritis and giant cell tumour of the tendon sheath: A case report

2001 ◽  
Author(s):  
S Kiraz ◽  
D Altýnok ◽  
Ý Ertenli ◽  
MA Öztürk ◽  
S Apras ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Case Report ◽  
Giant Cell ◽  
Giant Cell Tumour ◽  
Tendon Sheath ◽  
Cell Tumour

scholarly journals Giant-cell tumour of bone: cytological studies

1979 ◽  
Vol 40 (2) ◽  
pp. 201-209 ◽  
Author(s):  
K Kasahara ◽  
T Yamamuro ◽  
A Kasahara
Keyword(s):  
Giant Cell ◽  
Giant Cell Tumour ◽  
Cell Tumour

Giant-cell tumour of bone metastasising to the lungs

1998 ◽  
Vol 80-B (1) ◽  
pp. 43-47 ◽  
Author(s):  
K. A. Siebenrock ◽  
K. K. Unni ◽  
M. G. Rock
Keyword(s):  
Giant Cell ◽  
Giant Cell Tumour ◽  
Cell Tumour

Giant cell tumour of the first metatarsal: a case report

2004 ◽  
Vol 14 (1) ◽  
pp. 40-41
Author(s):  
Roop Singh ◽  
Ashwini Sharma ◽  
N. K. Magu ◽  
Rajeev Mittal
Keyword(s):  
Case Report ◽  
Giant Cell ◽  
Giant Cell Tumour ◽  
Cell Tumour ◽  
First Metatarsal
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