Gremlin1 expression associates with serrated pathway and favourable prognosis in colorectal cancer

2016 ◽  
Vol 69 (5) ◽  
pp. 831-838 ◽  
Author(s):  
Ari Pelli ◽  
Juha P Väyrynen ◽  
Kai Klintrup ◽  
Jyrki Mäkelä ◽  
Markus J Mäkinen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Serrated Pathway ◽  
Favourable Prognosis

scholarly journals Sa1163 Modelling the Adenoma and Serrated Pathway to Colorectal Cancer (ASCCA)

2013 ◽  
Vol 144 (5) ◽  
pp. S-218
Author(s):  
Marjolein J. Greuter ◽  
Xiang-Ming Xu ◽  
Jie-Bin Lew ◽  
Evelien Dekker ◽  
Ernst J. Kuipers ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Serrated Pathway

Receptor tyrosine kinase fusions act as a significant alternative driver of the serrated pathway in colorectal cancer development

2020 ◽  
Vol 251 (1) ◽  
pp. 74-86 ◽  
Author(s):  
Anthony W‐H Chan ◽  
Yi Pan ◽  
Joanna H‐M Tong ◽  
Raymond W‐M Lung ◽  
Johnny S‐H Kwan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tyrosine Kinase ◽  
Receptor Tyrosine Kinase ◽  
Cancer Development ◽  
Serrated Pathway

scholarly journals Serological immune response against ADAM10 pro-domain is associated with favourable prognosis in stage III colorectal cancer patients

Oncotarget ◽  
2016 ◽  
Vol 7 (48) ◽  
pp. 80059-80076 ◽  
Author(s):  
Sheila María Álvarez-Fernández ◽  
Marco Barbariga ◽  
Luca Cannizzaro ◽  
Carlo Vittorio Cannistraci ◽  
Laura Hurley ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Immune Response ◽  
Cancer Patients ◽  
Stage Iii ◽  
Favourable Prognosis ◽  
Colorectal Cancer Patients

scholarly journals Association of microRNA-31 with BRAF mutation, colorectal cancer survival and serrated pathway

2013 ◽  
Vol 35 (4) ◽  
pp. 776-783 ◽  
Author(s):  
K. Nosho ◽  
H. Igarashi ◽  
M. Nojima ◽  
M. Ito ◽  
R. Maruyama ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Braf Mutation ◽  
Cancer Survival ◽  
Colorectal Cancer Survival ◽  
Serrated Pathway

scholarly journals Prognostic Value of Microvascular Density in Dukes A and B (T1–T4, N0, M0) Colorectal Carcinomas

2009 ◽  
Vol 2009 ◽  
pp. 1-7 ◽  
Author(s):  
Rafael Uribarrena A ◽  
Javier Ortego ◽  
Javier Fuentes ◽  
Nuria Raventós ◽  
Pilar Parra ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Factor ◽  
Significant Influence ◽  
Prognostic Value ◽  
Microvascular Density ◽  
Colorectal Carcinomas ◽  
Favourable Prognosis ◽  
Vascular Area ◽  
The Mean

Background. Aproximatelly 30% of patients operated on for colorectal cancer (CRC), with an expectedly favourable prognosis (Dukes A-B/T1–T4, N0, M0) suffer recurrence and/or die.Method. In order to determine if tumor microvascular density (MVD) is a prognostic factor in CRC, samples from tumors of 104 Dukes A-B CRC patients were retrospectively studied. Immunohistochemistry was performed for anti-CD34 antibody to visualize tumor vascularisation. MVD was expressed as the total number of vessels and as the percentage of microvascular area. We calculated MVD with a morphometry program and performed descriptive, bivariate, and survival statistics.Results. The mean number of vessels was 37.37/200x field, and the mean vascular area was the 3.972%. 30% of the patients with<37 vessels/field, and 21% of the patients with>37 vessels/field, experienced recurrence/death. The 35% of patients with<4% of vascular area died following recurrence, compared with 14% of patients with ≥4% of vascular area. These differences in % of vascular area were statistically significant.Conclusion. MVD expressed as the total number of vessels had no a statistically significant influence on the evolution of CRC. However, neoplasias with a greater % of vascular were associated to a better outcome.

Sa1727 EZH2 Regulates microRNA-31 Expression in Colorectal Cancer and May Affect Differentiation and Evolution of the Serrated Pathway

2016 ◽  
Vol 150 (4) ◽  
pp. S358
Author(s):  
Itaru Yamamoto ◽  
Keisuke Ishigami ◽  
Hiroyoshi Kurihara ◽  
Reo Maruyama ◽  
Shinichi Kanno ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Serrated Pathway

scholarly journals The relationship between EZH2 expression and microRNA-31 in colorectal cancer and the role in evolution of the serrated pathway

Oncotarget ◽  
2016 ◽  
Vol 7 (11) ◽  
pp. 12704-12717 ◽  
Author(s):  
Hiroyoshi Kurihara ◽  
Reo Maruyama ◽  
Kazuya Ishiguro ◽  
Shinichi Kanno ◽  
Itaru Yamamoto ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Serrated Pathway ◽  
Ezh2 Expression ◽  
The Relationship
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