BCOR-CCNB3-positive soft tissue sarcoma with round-cell and spindle-cell histology: a series of four cases highlighting the pitfall of mimicking poorly differentiated synovial sarcoma

2016 ◽  
Vol 69 (5) ◽  
pp. 792-801 ◽  
Author(s):  
Wan-Shan Li ◽  
I-Chuang Liao ◽  
Mei-Chin Wen ◽  
Howard Haw-Chang Lan ◽  
Shih-Chen Yu ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Synovial Sarcoma ◽  
Spindle Cell ◽  
Round Cell ◽  
Poorly Differentiated

The Use of Adjuvant or Neoadjuvant Chemotherapy in Extremity and Truncal Sarcoma

2018 ◽  
Author(s):  
Robert J Canter
Keyword(s):  
Soft Tissue ◽  
Neoadjuvant Chemotherapy ◽  
Soft Tissue Sarcoma ◽  
Synovial Sarcoma ◽  
Distant Recurrence ◽  
Curative Intent ◽  
Pleomorphic Sarcoma ◽  
Level I ◽  
Meta Analyses ◽  
The Impact

Although neoadjuvant chemotherapy has been an established component of multimodality cancer care for patients with pediatric sarcomas for the past 25 years, the role of adjuvant or neoadjuvant chemotherapy in the management of adult patients with soft tissue sarcoma (STS) amenable to treatment with curative intent remains controversial. Overall, meta-analyses have revealed modest improvements in survival outcomes with the use of adjuvant or neoadjuvant chemotherapy, but individual trials have demonstrated inconsistent results leading some to question the robustness and external validity of the results. A recent randomized trial using anthracycline- and ifosfamide-based chemotherapy has provided further positive evidence in support of neoadjuvant chemotherapy for adult STS patients, but concerns persist regarding the risks of chemotherapy-related toxicities and the generalizability of the findings. Given the substantial risk of distant recurrence and disease-specific death for adult STS patients with tumors greater than 10 cm, especially those with synovial sarcoma and myxoid or round liposarcoma histologies, these patients should be strongly considered for neoadjuvant chemotherapy as part of a combined modality approach. The impact of recent level I data on the broader implementation of adjuvant or neoadjuvant chemotherapy in adult STS remains to be seen.  This review contains 5 figures and 34 references Key Words: chemotherapy, limb salvage, myxoid/round cell liposarcoma, multimodality therapy, soft tissue sarcoma, surgery, survival, synovial sarcoma, undifferentiated pleomorphic sarcoma  

scholarly journals The Effect and Assessment of Preoperative Chemotherapy in Spindle Cell Soft Tissue Sarcoma.

1996 ◽  
Vol 45 (2) ◽  
pp. 370-373
Author(s):  
Takeshi Minamizaki ◽  
Makoto Okuno ◽  
Kichizo Yamamoto ◽  
Kiyoo Furuse
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Preoperative Chemotherapy ◽  
Spindle Cell

scholarly journals Spindle Cell Hemangioendothelioma of the Temporal Muscle Resected with Zygomatic Osteotomy: A Case Report of an Unusual Intramuscular Lesion Mimicking Sarcoma

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Tomohiro Minagawa ◽  
Takeshi Yamao ◽  
Ryuta Shioya
Keyword(s):  
Case Report ◽  
Surgical Treatment ◽  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Spindle Cell ◽  
Neck Region ◽  
Benign Neoplasm ◽  
Low Grade ◽  
Temporal Muscle ◽  
Head And Neck Region

Spindle cell hemangioendothelioma (SCH) was originally described by Weiss and Enzinger (1986) as a low-grade angiosarcoma resembling both cavernous hemangioma and Kaposi's sarcoma. Recent studies suggest that SCH is a benign neoplasm or reactive lesion accompanying a congenital or acquired vascular malformation. Most SCHs present as one or more nodules affecting the dermis or subcutis of the distal extremities. Few reports describe SCH of the head and neck region; even fewer note intramuscular SCH. Here, we describe a case of SCH involving the temporal muscle mimicking soft tissue sarcoma, who had a successful surgical treatment with a coronal approach and zygomatic osteotomy.

scholarly journals Efficacy analysis of the aprepitant-combined antiemetic prophylaxis for non-round cell soft-tissue sarcoma patients received adriamycin and ifosfamide therapy

Medicine ◽  
2016 ◽  
Vol 95 (49) ◽  
pp. e5460 ◽  
Author(s):  
Hitoshi Kusaba ◽  
Hozumi Kumagai ◽  
Kyoko Inadomi ◽  
Tomoya Matsunobu ◽  
Katsumi Harimaya ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Round Cell ◽  
Efficacy Analysis ◽  
Antiemetic Prophylaxis

scholarly journals Synovial sarcoma in children and adolescents: the European Pediatric Soft Tissue Sarcoma Study Group prospective trial (EpSSG NRSTS 2005)

2015 ◽  
Vol 26 (3) ◽  
pp. 567-572 ◽  
Author(s):  
A. Ferrari ◽  
G.L. De Salvo ◽  
B. Brennan ◽  
M.M. van Noesel ◽  
A. De Paoli ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Children And Adolescents ◽  
Synovial Sarcoma ◽  
Prospective Trial ◽  
Study Group

Ultrastructural Features of a Poorly Differentiated Neoplasm Resembling Synovial Sarcoma

1977 ◽  
Vol 35 ◽  
pp. 526-527
Author(s):  
P. K. Simons
Keyword(s):  
Fine Structure ◽  
Light Microscopy ◽  
Synovial Sarcoma ◽  
Spindle Cell ◽  
White Male ◽  
Biphasic Pattern ◽  
Malignant Mesenchymal Tumor ◽  
Synovial Sarcomas ◽  
Poorly Differentiated ◽  
Histologic Differentiation

Synovial sarcoma is a malignant mesenchymal tumor most commonly occurring in the extremities, but is occasionally seen in the trunk, head, and neck regions. The well developed lesion exhibits a distinct biphasic histologic morphology consisting of a spindle cell fibrosarcomatous stroma and epithelial-lined pseudoacinar structures with an associated mucopolysaccharide secretion. The presence of this biphasic pattern is dependent upon the degree of histologic differentiation. Few studies of the fine structure of synovial sarcomas are available and none of the literature has been concerned with these neoplasms occurring in the less common areas. The ultrastructural features of a tumor classified as a poorly differentiated synovial sarcoma are presented.A mass of irregularly shaped, cerebreform tissue was surgically removed from the left side of the neck of a 61 year old white male. The majority of the tissue was fixed in neutral buffered formalin and prepared for light microscopy.

The Use of Adjuvant or Neoadjuvant Chemotherapy in Extremity and Truncal Sarcoma

2018 ◽  
Author(s):  
Robert J Canter
Keyword(s):  
Soft Tissue ◽  
Neoadjuvant Chemotherapy ◽  
Soft Tissue Sarcoma ◽  
Synovial Sarcoma ◽  
Distant Recurrence ◽  
Curative Intent ◽  
Pleomorphic Sarcoma ◽  
Level I ◽  
Meta Analyses ◽  
The Impact

Although neoadjuvant chemotherapy has been an established component of multimodality cancer care for patients with pediatric sarcomas for the past 25 years, the role of adjuvant or neoadjuvant chemotherapy in the management of adult patients with soft tissue sarcoma (STS) amenable to treatment with curative intent remains controversial. Overall, meta-analyses have revealed modest improvements in survival outcomes with the use of adjuvant or neoadjuvant chemotherapy, but individual trials have demonstrated inconsistent results leading some to question the robustness and external validity of the results. A recent randomized trial using anthracycline- and ifosfamide-based chemotherapy has provided further positive evidence in support of neoadjuvant chemotherapy for adult STS patients, but concerns persist regarding the risks of chemotherapy-related toxicities and the generalizability of the findings. Given the substantial risk of distant recurrence and disease-specific death for adult STS patients with tumors greater than 10 cm, especially those with synovial sarcoma and myxoid or round liposarcoma histologies, these patients should be strongly considered for neoadjuvant chemotherapy as part of a combined modality approach. The impact of recent level I data on the broader implementation of adjuvant or neoadjuvant chemotherapy in adult STS remains to be seen.  This review contains 5 figures and 34 references Key Words: chemotherapy, limb salvage, myxoid/round cell liposarcoma, multimodality therapy, soft tissue sarcoma, surgery, survival, synovial sarcoma, undifferentiated pleomorphic sarcoma  

scholarly journals Mediastinal Synovial Sarcoma: A Case Report and Literature Review

2003 ◽  
Vol 10 (7) ◽  
pp. 393-395 ◽  
Author(s):  
Linda SL Cheng ◽  
Gary MK Tse ◽  
Wilson WL Li ◽  
TW Lee ◽  
Anthony PC Yim
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Literature Review ◽  
Synovial Sarcoma ◽  
Spindle Cell ◽  
Diagnosis And Treatment ◽  
Soft Tissue Tumours ◽  
Unusual Location ◽  
Synovial Sarcomas ◽  
Proper Diagnosis

Synovial sarcomas are uncommon soft tissue tumours. Immunohistochemistry and cytogenetic techniques are essential for proper diagnosis and differentiation from other spindle cell neoplasms. A case of mediastinal synovial sarcoma is described, of which the unusual location, diagnosis and treatment form the basis of this report.

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