Role of hypoxia-related proteins in invasion of ameloblastoma cells: crosstalk between NOTCH1, hypoxia-inducible factor 1α, a disintegrin and metalloproteinase 12, and heparin-binding epidermal growth factor

2016 ◽  
Vol 69 (1) ◽  
pp. 99-106 ◽  
Author(s):  
Natacha Malu Miranda da Costa ◽  
Amanda Dalla Vechia Fialho ◽  
Carolina Carmine Proietti ◽  
Maria Sueli da Silva Kataoka ◽  
Ruy Gastaldoni Jaeger ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Hypoxia Inducible Factor ◽  
Heparin Binding ◽  
Hypoxia Inducible Factor 1Α ◽  
Epidermal Growth ◽  
A Disintegrin And Metalloproteinase ◽  
Related Proteins

scholarly journals Differential Pathways of Angiotensin II-Induced Extracellularly Regulated Kinase 1/2 Phosphorylation in Specific Cell Types: Role of Heparin-Binding Epidermal Growth Factor

2004 ◽  
Vol 18 (8) ◽  
pp. 2035-2048 ◽  
Author(s):  
Bukhtiar H. Shah ◽  
Akin Yesilkaya ◽  
J. Alberto Olivares-Reyes ◽  
Hung-Dar Chen ◽  
László Hunyady ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Cell Types ◽  
Specific Cell ◽  
Heparin Binding ◽  
Epidermal Growth

scholarly journals Role of membrane-anchored heparin-binding epidermal growth factor-like growth factor and CD9 on macrophages

1997 ◽  
Vol 328 (3) ◽  
pp. 923-928 ◽  
Author(s):  
Noriyuki OUCHI ◽  
Shinji KIHARA ◽  
Shizuya YAMASHITA ◽  
Shigeki HIGASHIYAMA ◽  
Tsutomu NAKAGAWA ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Surface Marker ◽  
Heparin Binding ◽  
Atherosclerotic Lesions ◽  
Growth Activity ◽  
Epidermal Growth ◽  
Egf Family ◽  
Formalin Fixed

Heparin-binding epidermal-growth-factor-like growth factor (HB-EGF) is a potent mitogen for smooth-muscle cells (SMCs) belonging to the EGF family. We have previously determined that HB-EGF is expressed in macrophages and SMCs of human atherosclerotic lesions and that its membrane-anchored precursor, proHB-EGF, also has a juxtacrine mitogenic activity which is markedly enhanced by CD9, a surface marker of lymphohaemopoietic cells. Therefore, when both proHB-EGF and CD9 are expressed on macrophages, they may strongly promote the development of atherosclerosis. In the present study we have investigated the changes in proHB-EGF and CD9 in THP-1 cells during differentiation into macrophages and by the addition of oxidized low-density lipoproteins (OxLDL) and assessed juxtacrine growth activity of THP-1 macrophages for human aortic SMCs. HB-EGF and CD9 at both the mRNA and the protein level were up-regulated after differentiation into macrophages, and further expression of HB-EGF was induced by the addition of OxLDL or lysophosphatidylcholine. Juxtacrine induction by formalin-fixed growth was suppressed to control levels by an inhibitor of HB-EGF and was partially decreased by anti-CD9 antibodies. These results suggest that co-expression of proHB-EGF and CD9 on macrophages plays an important role in the development of atherosclerosis by a juxtacrine mechanism.

Role of Heparin-Binding Epidermal Growth Factor–Like Growth Factor in Light-Induced Photoreceptor Degeneration in Mouse Retina

2013 ◽  
Vol 54 (6) ◽  
pp. 3815 ◽  
Author(s):  
Yuki Inoue ◽  
Kazuhiro Tsuruma ◽  
Tomohiro Nakanishi ◽  
Atsushi Oyagi ◽  
Yuta Ohno ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Mouse Retina ◽  
Heparin Binding ◽  
Photoreceptor Degeneration ◽  
Epidermal Growth

Role of heparin-binding epidermal growth factor–like growth factor as a hepatotrophic factor in rat liver regeneration after partial hepatectomy

Hepatology ◽  
1995 ◽  
Vol 22 (5) ◽  
pp. 1584-1590 ◽  
Author(s):  
Shinichi Kiso ◽  
Sumio Kawata ◽  
Shinji Tamura ◽  
Shigeki Higashiyama ◽  
Nobuyuki Ito ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Liver Regeneration ◽  
Partial Hepatectomy ◽  
Rat Liver ◽  
Heparin Binding ◽  
Rat Liver Regeneration ◽  
Epidermal Growth

Possible pro-inflammatory role of heparin-binding epidermal growth factor-like growth factor in the active phase of systemic sclerosis

2017 ◽  
Vol 45 (2) ◽  
pp. 182-188
Author(s):  
Megumi Hirabayashi ◽  
Yoshihide Asano ◽  
Takashi Yamashita ◽  
Shunsuke Miura ◽  
Kouki Nakamura ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Active Phase ◽  
Heparin Binding ◽  
Epidermal Growth

scholarly journals Role of membrane-bound heparin-binding epidermal growth factor-like growth factor (HB-EGF) in renal epithelial cell branching

2002 ◽  
Vol 61 (6) ◽  
pp. 1968-1979 ◽  
Author(s):  
Tsukasa Takemura ◽  
Satoshi Hino ◽  
Mituru Okada ◽  
Yuka Murata ◽  
Hidehiko Yanagida ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epithelial Cell ◽  
Epidermal Growth Factor ◽  
Heparin Binding ◽  
Renal Epithelial Cell ◽  
Epidermal Growth ◽  
Membrane Bound
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