Differentiated squamous intraepithelial neoplasia associated with squamous cell carcinoma of the anal canal

2015 ◽  
Vol 68 (6) ◽  
pp. 834-842 ◽  
Author(s):  
Jason K Wasserman ◽  
Justin Bateman ◽  
Kien T Mai
Keyword(s):  
Squamous Cell Carcinoma ◽  
Anal Canal ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Intraepithelial Neoplasia ◽  
Squamous Intraepithelial Neoplasia

scholarly journals Immunohistochemical expression of p16INK4A in the lesions of uterine cervix

2020 ◽  
Vol 7 (10) ◽  
pp. A502-508
Author(s):  
Niharika Rawat ◽  
Shivapriya Rajan
Keyword(s):  
Cervical Cancer ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Intraepithelial Neoplasia ◽  
Low Grade ◽  
High Grade ◽  
Cervical Lesions ◽  
Cancer Management ◽  
Squamous Intraepithelial Neoplasia

Background: Cervical cancer is the major cause of cancer deaths among women. Globally, around 5,70,000 new cases of cervical cancer and 3,11,000 deaths occurred in the year 2018. In India, Cervical cancer is a leading cause of cancer related mortality among women and the number of deaths is 60,000 per year among 97,000 diagnosed patients, especially those from lower socioeconomic group. Human Papilloma Virus (HPV) plays a crucial role in causing cervical dysplasia. This is done by upregulating p16INK4A, a cyclin dependent kinase inhibitor through interaction with cellular regulatory proteins. Hence p16INK4A can be used as a biomarker, since it is directly related variable for the presence of HPV. This study was conducted to evaluate the expression of p16INK4A in benign, premalignant and malignant cervical lesions and to assess its utility in diagnosing and grading cervical lesions. Methods: A total of 80 cervical specimens categorized histopathologically into nonspecific cervicitis, low grade squamous intraepithelial neoplasia (LSIL), high grade squamous intraepithelial neoplasia (HSIL) and squamous cell carcinoma cervix were included in this prospective study of one-year duration. Immunohistochemical study of p16INK4A were interpreted qualitatively and semi-quantitatively by Allred scoring system (0 to 8 points) which measures the proportion of stained cells and intensity of staining of cells. The collected data were statistically analyzed by ANOVA and chi square test. Result: Qualitative method showed absence of p16INK4A expression in all nonspecific cervicitis. 16.7% (2/12) LSIL, 100% (12/12) HSIL and 100% (28/28) squamous cell carcinoma cases showed p16INK4A positivity. Allred scoring of p16INK4A showed 66% (8/12) HSIL and 85.7% (24/28) squamous cell carcinoma cases with score 3 positivity. Hence high-grade lesions showed higher expression of this marker. Conclusion: IHC expression of p16INK4A showed increasing degree of expression from benign to premalignant and malignant lesions suggesting its diagnostic and prognostic value in the cervical cancer management

Conjunctival squamous intraepithelial neoplasia and its differential diagnosis

2021 ◽  
pp. jclinpath-2020-207302
Author(s):  
Alexander Reese ◽  
Curtis Edward Margo
Keyword(s):  
Squamous Cell Carcinoma ◽  
Differential Diagnosis ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Invasive Carcinoma ◽  
Intraepithelial Neoplasia ◽  
Sebaceous Carcinoma ◽  
Pseudoepitheliomatous Hyperplasia ◽  
Squamous Intraepithelial Neoplasia

Conjunctival squamous intraepithelial neoplasia (CSIN) represents the in situ precursor of squamous cell carcinoma. The graded severity of intraepithelial dysplasia is considered a measure of risk for progression to invasive carcinoma. The range of cytoarchitectural changes in CSIN overlaps those of reactive atypia, squamous epithelial papilloma and in situ sebaceous carcinoma. Pseudoepitheliomatous hyperplasia and benign hereditary dyskeratosis of the conjunctiva are conditions without risk of neoplastic transform that are potentially mistaken for CSIN.

scholarly journals Endoscopic submucosal dissection for early squamous cell carcinoma in the anal canal and Lugol chromoendoscopy for assessment of the lateral margin

2018 ◽  
Vol 06 (09) ◽  
pp. E1130-E1133
Author(s):  
Takeshi Uozumi ◽  
Tetsuya Sumiyoshi ◽  
Hitoshi Kondo ◽  
Takeyoshi Minagawa ◽  
Ryoji Fujii ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Anal Canal ◽  
Endoscopic Submucosal Dissection ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Intraepithelial Neoplasia ◽  
Dentate Line ◽  
Lateral Margin ◽  
En Bloc ◽  
Submucosal Dissection

AbstractA 66-year-old man underwent follow-up colonoscopy after colon polypectomy. The retroflexed view of the anal canal with white-light imaging revealed a whitish, slightly elevated lesion on the dentate line and an ill-defined flat lesion. A biopsy of the whitish elevation revealed squamous cell carcinoma (SCC), and endoscopic submucosal dissection (ESD) was planned. The lateral margin of the SCC was identified by spraying with Lugol’s iodine, and the tumor was resected en bloc with no complications. The pathological findings were SCC in situ with parakeratosis in the whitish elevation and high-grade intraepithelial neoplasia in the ill-defined flat lesion, which exhibited a wide iodine-unstained area by chromoendoscopy. Early SCC in the anal canal is a rare gastrointestinal cancer, and Lugol chromoendoscopy helped visualize the tumor margin for ESD.

The role of microsatellite instability in cervical intraepithelial neoplasia and squamous cell carcinoma of the cervix

2003 ◽  
Vol 89 (3) ◽  
pp. 434-439 ◽  
Author(s):  
Yick-Fu Wong ◽  
Tak-Hong Cheung ◽  
Kin-Yan Poon ◽  
Vivian Wei Wang ◽  
James C.B Li ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Microsatellite Instability ◽  
Cell Carcinoma ◽  
Cervical Intraepithelial Neoplasia ◽  
Squamous Cell ◽  
Intraepithelial Neoplasia

scholarly journals Anal Cancer with Mediastinal Lymph Node Metastasis

2021 ◽  
pp. 1-4
Author(s):  
Mangalore Amith Shenoy ◽  
Lydia Winnicka ◽  
Leili Mirsadraei ◽  
Douglas Marks
Keyword(s):  
Breast Cancer ◽  
Squamous Cell Carcinoma ◽  
Anal Canal ◽  
Cell Carcinoma ◽  
Anal Cancer ◽  
Squamous Cell ◽  
Mediastinal Lymph Node ◽  
Hpv Infection ◽  
Mediastinal Lymphadenopathy ◽  
Prior History

Squamous cell carcinoma of the anal canal remains rare, with metastatic disease even less commonly reported. We present a case of a patient with both a prior history of squamous cell carcinoma of the anal canal as well as breast cancer, who was without evidence of disease for 1 year. She was subsequently found to have FDG-avid mediastinal lymphadenopathy, initially assumed to be related to her more recent breast cancer. However, a biopsy confirmed recurrent anal cancer, with HPV infection. This represents a novel site of spread for anal cancer, one not yet reported in the literature.

Squamous cell carcinoma of the anal canal

2018 ◽  
Vol 42 (5) ◽  
pp. 486-492 ◽  
Author(s):  
Michael Morton ◽  
Nelya Melnitchouk ◽  
Ronald Bleday
Keyword(s):  
Squamous Cell Carcinoma ◽  
Anal Canal ◽  
Cell Carcinoma ◽  
Squamous Cell
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