A semi-automated method to assess intraepidermal nerve fibre density in human skin biopsies

2015 ◽  
Vol 68 (5) ◽  
pp. 657-665 ◽  
Author(s):  
Shanon Seger ◽  
Manuel Stritt ◽  
Kathrin Doppler ◽  
Stephan Frank ◽  
Adrian Panaite ◽  
...  
Keyword(s):  
Nerve Fibre ◽  
Human Skin ◽  
Fibre Density ◽  
Automated Method ◽  
Skin Biopsies

Changes in corneocyte element concentrations occur in skin inner stratum corneum

1990 ◽  
Vol 48 (2) ◽  
pp. 146-147
Author(s):  
R. R. Warner
Keyword(s):  
Stratum Corneum ◽  
Human Skin ◽  
Element Concentration ◽  
Skin Barrier ◽  
Barrier Properties ◽  
Brick Wall ◽  
Inorganic Elements ◽  
Dry Skin ◽  
Skin Biopsies ◽  
Intercellular Lipid

Keratinocytes undergo maturation during their transit through the viable layers of skin, and then abruptly transform into flattened, anuclear corneocytes that constitute the cellular component of the skin barrier, the stratum corneum (SC). The SC is generally considered to be homogeneous in its structure and barrier properties, and is often shown schematically as a featureless brick wall, the “bricks” being the corneocytes, the “mortar” being intercellular lipid. Previously we showed the outer SC was not homogeneous in its composition, but contained steep gradients of the physiological inorganic elements Na, K and Cl, likely originating from sweat salts. Here we show the innermost corneocytes in human skin are also heterogeneous in composition, undergoing systematic changes in intracellular element concentration during transit into the interior of the SC.Human skin biopsies were taken from the lower leg of individuals with both “good” and “dry” skin and plunge-frozen in a stirred, cooled isopentane/propane mixture.

A Meta-Analysis of Intraepidermal Nerve Fibre Density in Healthy and Neuropathic Subjects: A Proposed Guidance Model

2018 ◽  
Author(s):  
Alexandros Samolis ◽  
maria Piagkou ◽  
Constantinus Politis ◽  
Nikolaos Pantazis ◽  
Theodore Troupis ◽  
...  
Keyword(s):  
Nerve Fibre ◽  
Meta Analysis ◽  
Fibre Density ◽  
Guidance Model

scholarly journals Laser capture microdissection for transcriptomic profiles in human skin biopsies

2018 ◽  
Vol 19 (1) ◽  
Author(s):  
Silvia Santoro ◽  
Ignazio Diego Lopez ◽  
Raffaella Lombardi ◽  
Andrea Zauli ◽  
Ana Maria Osiceanu ◽  
...  
Keyword(s):  
Human Skin ◽  
Laser Capture Microdissection ◽  
Skin Biopsies ◽  
Laser Capture

scholarly journals Three-dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies

10.3791/50331 ◽  
2013 ◽  
Author(s):  
Jacqueline R. Dauch ◽  
Chelsea N. Lindblad ◽  
John M. Hayes ◽  
Stephen I. Lentz ◽  
Hsinlin T. Cheng
Keyword(s):  
Human Skin ◽  
Three Dimensional ◽  
Nerve Fibers ◽  
Three Dimensional Imaging ◽  
Skin Biopsies

Intraepidermal nerve fibre density at wrist level in diabetic and non-diabetic patients

2009 ◽  
Vol 26 (11) ◽  
pp. 1120-1126 ◽  
Author(s):  
N. O. B. Thomsen ◽  
E. Englund ◽  
S. Thrainsdottir ◽  
I. Rosén ◽  
L. B. Dahlin
Keyword(s):  
Nerve Fibre ◽  
Diabetic Patients ◽  
Fibre Density

Zinc sulphate-induced anosmia decreases the nerve fibre density in the anterior cerebral artery of the rat

2001 ◽  
Vol 94 (1-2) ◽  
pp. 102-108 ◽  
Author(s):  
Jacqueline C.M van Denderen ◽  
Gerda W van Wieringen ◽  
Berend Hillen ◽  
Ronald L.A.W Bleys
Keyword(s):  
Nerve Fibre ◽  
Cerebral Artery ◽  
Zinc Sulphate ◽  
Anterior Cerebral Artery ◽  
Fibre Density

3D imaging of cleared human skin biopsies using light-sheet microscopy: A new way to visualize in-depth skin structure

2018 ◽  
Vol 24 (2) ◽  
pp. 294-303 ◽  
Author(s):  
S. Abadie ◽  
C. Jardet ◽  
J. Colombelli ◽  
B. Chaput ◽  
A. David ◽  
...  
Keyword(s):  
Human Skin ◽  
3D Imaging ◽  
Light Sheet ◽  
Skin Structure ◽  
Light Sheet Microscopy ◽  
Skin Biopsies

scholarly journals Intraepidermal nerve fibre density (ienfd) in the assessment of central nervous system disease

2015 ◽  
Vol 357 ◽  
pp. e247-e248
Author(s):  
C. Ramirez Rondon ◽  
H. Rojas ◽  
I. Sazunic ◽  
E. Mullins ◽  
J. Honeyman ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Nerve Fibre ◽  
Central Nervous System Disease ◽  
Nervous System Disease ◽  
Fibre Density ◽  
System Disease
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