Primary well-differentiated liposarcoma of the eyelid clinically masquerading as a benign tumour: a rare entity confirmed by murine double minute 2 fluorescencein-situhybridization

2015 ◽  
Vol 67 (4) ◽  
pp. 582-585
Author(s):  
Manish M Subramaniam ◽  
Alvin Lim Soon Tiong ◽  
Lim Tse Hui ◽  
Victor Lee Kwan Min ◽  
Shantha Amrith ◽  
...  
Keyword(s):  
Benign Tumour ◽  
Rare Entity ◽  
Double Minute ◽  
Murine Double Minute ◽  
Well Differentiated

scholarly journals MDM2 Amplified Sarcomas: A Literature Review

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 496
Author(s):  
Raf Sciot
Keyword(s):  
Suppressor Gene ◽  
Negative Regulator ◽  
Low Grade ◽  
P53 Mutations ◽  
Lipomatous Tumor ◽  
Double Minute ◽  
Genetic Features ◽  
Murine Double Minute ◽  
Well Differentiated ◽  
Mdm2 Amplification

Murine Double Minute Clone 2, located at 12q15, is an oncogene that codes for an oncoprotein of which the association with p53 was discovered 30 years ago. The most important function of MDM2 is to control p53 activity; it is in fact the best documented negative regulator of p53. Mutations of the tumor suppressor gene p53 represent the most frequent genetic change in human cancers. By overexpressing MDM2, cancer cells have another means to block p53. The sarcomas in which MDM2 amplification is a hallmark are well-differentiated liposarcoma/atypical lipomatous tumor, dedifferentiated liposarcoma, intimal sarcoma, and low-grade osteosarcoma. The purpose of this review is to summarize the typical clinical, histopathological, immunohistochemical, and genetic features of these tumors.

Application of Molecular Biology to Individualize Therapy for Patients with Liposarcoma

2015 ◽  
pp. 213-218 ◽  
Author(s):  
Gulam Abbas Manji ◽  
Samuel Singer ◽  
Andrew Koff ◽  
Gary K. Schwartz
Keyword(s):  
Retrospective Studies ◽  
Soft Tissue Sarcomas ◽  
Definitive Treatment ◽  
Cyclin Dependent Kinase ◽  
Round Cell ◽  
Lipomatous Tumor ◽  
Appropriate Treatment ◽  
Double Minute ◽  
Murine Double Minute ◽  
Well Differentiated

Liposarcomas are one the most common of over 50 histologic subtypes of soft tissue sarcomas that are mostly resistant to chemotherapy. Histologically, liposarcomas themselves are heterogeneous and fall into four distinct subtypes: well-differentiated/atypical lipomatous tumor, dedifferentiated liposarcoma, myxoid (round cell) liposarcoma, and pleomorphic liposarcoma. Surgical resection with negative margins remains the mainstay for definitive treatment for operable disease. For unresectable disease, retrospective studies have identified myxoid (round cell) and pleomorphic sarcomas to be relatively responsive to chemotherapy. Recent studies have identified distinct genetic aberrations that not only aid in the diagnosis of particular liposarcoma subtypes, but represent actionable targets as they are considered central to disease pathogenesis. Cyclin-dependent kinase 4 (CDK4) and murine double minute 2 (MDM2) are overexpressed in well-differentiated and dedifferentiated liposarcomas and offer tantalizing opportunities that are being pursued in clinical trials. Myxoid (round cell) liposarcomas appear to be sensitive to trabectedin, which is currently under U.S. Food and Drug Administration (FDA) review. Liposarcomas do not represent a uniform disease and understanding the underlying molecular mechanism will help not only in accurate diagnosis but in selecting the appropriate treatment.

scholarly journals Contribution of Murine Double Minute 2 Genotypes to Colorectal Cancer Risk in Taiwan

2018 ◽  
Vol 15 (5) ◽  
pp. 405-411 ◽  
Author(s):  
TE-CHENG YUEH ◽  
YI-WEN HUNG ◽  
TZU-CHING SHIH ◽  
CHENG-NAN WU ◽  
SHOU-CHENG WANG ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Colorectal Cancer Risk ◽  
Double Minute ◽  
Murine Double Minute

scholarly journals Murine double minute-2 mediates exercise-induced angiogenesis in adipose tissue of diet-induced obese mice

2020 ◽  
Vol 130 ◽  
pp. 104003
Author(s):  
Thomas Loustau ◽  
Eugénie Coudiere ◽  
Esma Karkeni ◽  
Jean-François Landrier ◽  
Bernard Jover ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Obese Mice ◽  
Double Minute ◽  
Murine Double Minute ◽  
Exercise Induced

scholarly journals The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth

1993 ◽  
Vol 13 (1) ◽  
pp. 301-306 ◽  
Author(s):  
C A Finlay
Keyword(s):  
P53 Protein ◽  
Mutant P53 ◽  
Wild Type ◽  
Rat Embryo ◽  
Ras Gene ◽  
Double Minute ◽  
Murine Double Minute ◽  
Low Levels ◽  
Wild Type P53 ◽  
P53 Genes

Expression of a p53-associated protein, Mdm-2 (murine double minute-2), can inhibit p53-mediated transactivation. In this study, overexpression of the Mdm-2 protein was found to result in the immortalization of primary rat embryo fibroblasts (REFs) and, in conjunction with an activated ras gene, in the transformation of REFs. The effect of wild-type p53 on the transforming properties of mdm-2 was determined by transfecting REFs with ras, mdm-2, and normal p53 genes. Transfection with ras plus mdm-2 plus wild-type p53 resulted in a 50% reduction in the number of transformed foci (relative to the level for ras plus mdm-2); however, more than half (9 of 17) of the cell lines derived from these foci expressed low levels of a murine p53 protein with the characteristics of a wild-type p53. These results are in contrast to previous studies which demonstrated that even minimal levels of wild-type p53 are not tolerated in cells transformed by ras plus myc, E1A, or mutant p53. The mdm-2 oncogene can overcome the previously demonstrated growth-suppressive properties of p53.

Fibrosarcoma of the Ovary Arising in a Fibrothecomatous Tumor With Minor Sex Cord Elements

2003 ◽  
Vol 127 (1) ◽  
pp. 81-84 ◽  
Author(s):  
Hwei-Yee Lee ◽  
Qasim Ahmed
Keyword(s):  
Ovarian Tumor ◽  
De Novo ◽  
Atypical Hyperplasia ◽  
Rare Entity ◽  
Postmenopausal Bleeding ◽  
Ovarian Mass ◽  
Computed Tomographic ◽  
Computed Tomographic Scan ◽  
Well Differentiated ◽  
The Right

Abstract We report the case of a 69-year-old woman who presented with postmenopausal bleeding. Endometrial curettings showed complex atypical hyperplasia with focal well-differentiated adenocarcinoma. A computed tomographic scan of the abdomen revealed a right ovarian mass. Histologically, the right ovarian tumor was a fibrothecoma with minor sex cord elements showing focal fibrosarcomatous change. Fibrosarcoma of the ovary is a rare tumor that is considered to arise de novo or secondary to benign fibromatous tumors. Fibrothecoma of the ovary with minor sex cord elements is also a rare entity. To the best of our knowledge, this is the first reported case of a fibrosarcoma arising in a fibrothecoma with minor sex cord elements.

scholarly journals Association of Murine Double Minute 2 Genotypes and Lung Cancer Risk

In Vivo ◽  
2020 ◽  
Vol 34 (3) ◽  
pp. 1047-1052
Author(s):  
YU-CHAO LIN ◽  
WEN-SHIN CHANG ◽  
TE-CHUN SHEN ◽  
HSIN-TING LI ◽  
CHIA-HSIANG LI ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Double Minute ◽  
Murine Double Minute
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