EGFR expression and copy number changes in low T-stage oral squamous cell carcinomas

2013 ◽  
Vol 63 (2) ◽  
pp. 271-278 ◽  
Author(s):  
Matthias Rössle ◽  
Claudia S Weber ◽  
Lena Züllig ◽  
Nicole Graf ◽  
Wolfram Jochum ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Copy Number ◽  
Squamous Cell Carcinomas ◽  
Oral Squamous Cell Carcinomas ◽  
T Stage ◽  
Egfr Expression ◽  
Copy Number Changes

scholarly journals Impact of Nuclear Interleukin-1 Alpha and EGFR Expression on Recurrence and Survival Outcomes in Oral Squamous Cell Carcinomas

2019 ◽  
Vol 2019 ◽  
pp. 1-12
Author(s):  
Anand Rajan ◽  
Katherine N. Gibson-Corley ◽  
Allen B. Choi ◽  
Georgina K. Ofori-Amanfo ◽  
Patrick Ten Eyck ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Prognostic Value ◽  
Interleukin 1 ◽  
Progression Free Survival ◽  
Squamous Cell Carcinomas ◽  
Survival Outcomes ◽  
Free Survival ◽  
Cytoplasmic Expression ◽  
Oral Squamous Cell Carcinomas ◽  
Egfr Expression

Interleukin-1 alpha (IL-1α) is a pleiotropic cytokine involved in inflammation and immune response and is upregulated in many solid tumors including head and neck squamous cell carcinomas. Although IL-1αexpression is generally associated with poor prognosis, the implications of the subcellular localization of IL-1αexpression in patient outcomes are poorly understood. This study is aimed at investigating the prognostic value of nuclear and cytoplasmic immunohistochemical IL-1αexpression in oral squamous cell carcinomas (OSCCs). Tissue microarrays containing 146 OSCCs were analyzed for IL-1αand epidermal growth factor receptor (EGFR) expression by immunohistochemistry. IL-1αand EGFR expression scores were correlated with clinicopathological parameters and survival outcomes. IL-1αexpression was observed in the nuclear and/or cytoplasmic compartments in 98% of evaluable tumors and 78% of tumors expressed IL-1αin both compartments. There were no differences observed in overall survival or progression-free survival between high, moderate, or negative IL-1αnuclear/cytoplasmic expression scores. When IL-1αnuclear/cytoplasmic expression scores were stratified by positive or negative EGFR expression, tumors with a combined EGFR-positive and high nuclear IL-1αexpression profile were significantly more likely to possess perineural invasion and were significantly associated with a high risk of tumor recurrence and worse progression-free survival compared to all other EGFR and combined IL-1α/EGFR expression profiles. Altogether, nuclear IL-1αexpression may enhance the prognostic value of EGFR in OSCC and warrants further study as a prognostic biomarker for recurrence.

p53 alterations in betel quid- and tobacco-associated oral squamous cell carcinomas from Taiwan

2007 ◽  
Vol 27 (6) ◽  
pp. 243-248 ◽  
Author(s):  
Yong-Kie Wong ◽  
Tsung-Yun Liu ◽  
Kuo-Wei Chang ◽  
Shu-Chun Lin ◽  
Tsurn-Waan Chao ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Betel Quid ◽  
Oral Squamous Cell Carcinomas

scholarly journals PO-073 Outcomes and patterns of failure of oral squamous cell carcinomas treated post-operatively with IMRT

2019 ◽  
Vol 132 ◽  
pp. 38
Author(s):  
R. Waldram ◽  
A. Taylor ◽  
R. Prestwich ◽  
S. Whittam ◽  
L. Murray ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Patterns Of Failure ◽  
Oral Squamous Cell Carcinomas
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