Referral system has a diminished difference in the risk for hepatic encephalopathy development among each etiology in patients with acute liver injury

2022 ◽  
Author(s):  
Keisuke Kakisaka ◽  
Yuji Suzuki ◽  
Fumiaki Takahashi ◽  
Yasuhiro Takikawa
Keyword(s):  
Hepatic Encephalopathy ◽  
Liver Injury ◽  
Acute Liver Injury ◽  
Referral System

scholarly journals Early identification using the referral system prolonged the time to onset for hepatic encephalopathy after diagnosing severe acute liver injury

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Keisuke Kakisaka ◽  
Yuji Suzuki ◽  
Hiroaki Abe ◽  
Takuya Watanabe ◽  
Kenji Yusa ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Hepatic Encephalopathy ◽  
Liver Injury ◽  
Early Identification ◽  
Total Bilirubin ◽  
Acute Liver Injury ◽  
Referral System ◽  
Significant Difference ◽  
Risk Of Progression ◽  
Time To Onset

Abstract In 2004, we implemented a referral system for patients with acute liver injury (ALI) based on an established formula that estimates the risk of progression to acute live failure (ALF); however, the benefits of the system for patients with severe acute liver injury (SLI) remain unclear. We have evaluated the clinical significance of the referral system for SLI patients. Patients with ALI/SLI who were consecutively and prospectively listed on the system between 2004 and 2018 were analyzed. Of the 371 ALI/SLI/ALF patients on the system, 124 satisfied the criteria for SLI; 34 of these 124 progressed to SLI after registration. Multivariate analysis using age, sex, AST, ALT, creatinine, total bilirubin, prothrombin, presence of hepatic encephalopathy (HE), and SLI at registration revealed that HE was associated with high mortality. Among the 23 patients who developed HE, five who progressed to SLI after registration showed an increased time to HE development compared with patients who had SLI at the time of registration. However, there was no significant difference in survival time after HE development. We concluded that early identification of SLI patients using the referral system increased the time from SLI diagnosis to HE development.

scholarly journals Valproic acid induced acute liver injury resulting in hepatic encephalopathy- a case report and literature review

2018 ◽  
Vol 8 (5) ◽  
pp. 311-314 ◽  
Author(s):  
Vijay Gayam ◽  
Amrendra Kumar Mandal ◽  
Mazin Khalid ◽  
Binav Shrestha ◽  
Pavani Garlapati ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Case Report ◽  
Hepatic Encephalopathy ◽  
Liver Injury ◽  
Literature Review ◽  
Acute Liver Injury

scholarly journals Yellow fever in a traveller returning from Suriname to the Netherlands, March 2017

2017 ◽  
Vol 22 (11) ◽  
Author(s):  
Marjan Wouthuyzen-Bakker ◽  
Marjolein Knoester ◽  
Aad P van den Berg ◽  
Corine H GeurtsvanKessel ◽  
Marion PG Koopmans ◽  
...  
Keyword(s):  
Intensive Care ◽  
Hepatic Encephalopathy ◽  
Liver Injury ◽  
The Netherlands ◽  
Yellow Fever ◽  
Acute Liver Injury ◽  
World Health ◽  
Rt Pcr ◽  
The World ◽  
Health Organization

A Dutch traveller returning from Suriname in early March 2017, presented with fever and severe acute liver injury. Yellow fever was diagnosed by (q)RT-PCR and sequencing. During hospital stay, the patient’s condition deteriorated and she developed hepatic encephalopathy requiring transfer to the intensive care. Although yellow fever has not been reported in the last four decades in Suriname, vaccination is recommended by the World Health Organization for visitors to this country.

Aloe-Emodin Quinone Pretreatment Reduces Acute Liver Injury Induced by Carbon Tetrachloride

2000 ◽  
Vol 87 (5) ◽  
pp. 229-233 ◽  
Author(s):  
Beatrice Arosio ◽  
Nicoletta Gagliano ◽  
Lorena Maria Pia Fusaro ◽  
Luciano Parmeggiani ◽  
Jacopo Tagliabue ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Acute Liver Injury ◽  
Aloe Emodin

Explore the mechanism of Swertia mussotii Franch. for hepatoprotective effects with iTRAQ-LC-MS/MS

2020 ◽  
Vol 23 ◽  
Author(s):  
Haixia Yun ◽  
Xinyu Wu ◽  
Yiwei Ding ◽  
Wendou Xiong ◽  
Xianglan Duan ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Total Bilirubin ◽  
Acute Liver Injury ◽  
Proteome Analysis ◽  
Ppi Networks ◽  
Hepatoprotective Effects

Background and Objective : A Tibetan traditional herb named Swertia mussotii Franch., also called “Zangyinchen” by the local people of Qinghai-Tibet area, has been used to protect the liver from injury for many years. However, the curative effect and molecular mechanism of the herb have not been demonstrated clearly. Materials and Methods: In our study, serum alanine aminotransferase, aspartate aminotransferase, total bilirubin levels were examined after S. mussotii Franch. treatment in the acute liver injury of the carbon tetrachloride-induced rat model. Then, Proteome Analysis was applied to explore the potential mechanism of SMT for hepatoprotective effects after iTRAQLC-MS/MS analysis (isobaric tag for relative and absolute quantification-liquid chromatograph-mass spectrometer with tandem mass spectrometry). Results: Serum results showed, alanine aminotransferase, aspartate aminotransferase, total bilirubin levels of rats with acute liver injury were all improved with SMT treatment. Moreover, Proteome Analysis suggested that, with S. Mussotii Franch. treatment, the levels of lipid catabolic process and lipid homeostasis were all enhanced. And the results of protein-protein interaction (PPI) analysis illustrated that these proteins assembled in PPI networks were found almost significantly enriched in response to lipid, negative regulation of lipase activity, response to lipopolysaccharide etc. Furthermore, the downregulated MRP14 and MRP8 proteins were found involved in the lipid metabolism, which may indicate the mechanism of SMT protection liver from ALI induced by carbon tetrachloride. Conclusion: SMT herb could play a role in hepatoprotection and alleviate the effect of acute liver injury by impacting the lipid metabolism associated biological process.

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