Ratio of von Willebrand factor antigen to ADAMTS13 activity is a useful biomarker for acute‐on‐chronic liver failure development and prognosis in patients with liver cirrhosis

2021 ◽  
Author(s):  
Masahide Enomoto ◽  
Hiroaki Takaya ◽  
Tadashi Namisaki ◽  
Yukihisa Fujinaga ◽  
Norihisa Nishimura ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Liver Failure ◽  
Von Willebrand Factor ◽  
Chronic Liver ◽  
Adamts13 Activity ◽  
Chronic Liver Failure ◽  
Von Willebrand Factor Antigen ◽  
Von Willebrand ◽  
Willebrand Factor ◽  
Factor Antigen

scholarly journals von Willebrand Factor Antigen, von Willebrand Factor Propeptide, and ADAMTS13 in Carotid Stenosis and Their Relationship with Cerebral Microemboli

2020 ◽  
Author(s):  
Stephen J. X. Murphy ◽  
Soon Tjin Lim ◽  
Fionnuala Hickey ◽  
Justin A. Kinsella ◽  
Deirdre R. Smith ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Carotid Stenosis ◽  
Blood Group ◽  
Von Willebrand Factor ◽  
Adamts13 Activity ◽  
Von Willebrand Factor Antigen ◽  
Asymptomatic Patients ◽  
Von Willebrand ◽  
Willebrand Factor ◽  
Factor Antigen

Abstract Background The relationship between von Willebrand factor antigen (VWF:Ag), VWF propeptide (VWFpp), VWFpp/VWF:Ag ratio, ADAMTS13 activity, and microembolic signal (MES) status in carotid stenosis is unknown. Methods This prospective, multicenter study simultaneously assessed plasma VWF:Ag levels, VWFpp levels and ADAMTS13 activity, and their relationship with MES in asymptomatic versus symptomatic moderate-to-severe (≥50–99%) carotid stenosis patients. One-hour transcranial Doppler ultrasound of the middle cerebral arteries classified patients as MES+ve or MES−ve. Results Data from 34 asymptomatic patients were compared with 43 symptomatic patients in the “early phase” (≤4 weeks) and 37 patients in the “late phase” (≥3 months) after transient ischemic attack (TIA)/ischemic stroke. VWF:Ag levels were higher (p = 0.049) and VWFpp/VWF:Ag ratios lower (p = 0.006) in early symptomatic than in asymptomatic patients overall, and in early symptomatic versus asymptomatic MES−ve subgroups (p ≤0.02). There were no intergroup differences in VWFpp expression or ADAMTS13 activity (p ≥0.05). VWF:Ag levels and ADAMTS13 activity decreased (p ≤ 0.048) and VWFpp/VWF:Ag ratios increased (p = 0.03) in symptomatic patients followed up from the early to late phases after TIA/stroke. Although there were no differences in the proportions of symptomatic and asymptomatic patients with blood group O, a combined analysis of early symptomatic and asymptomatic patients revealed lower median VWF:Ag levels in patients with blood group O versus those without blood group O (9.59 vs. 12.32 µg/mL, p = 0.035). Discussion VWF:Ag expression, a marker of endothelial ± platelet activation, is enhanced in recently symptomatic versus asymptomatic carotid stenosis patients, including in MES−ve patients, and decreases with ADAMTS13 activity over time following atherosclerotic TIA/ischemic stroke.

scholarly journals Plasma von Willebrand factor levels predict in-hospital survival in patients with acute-on-chronic liver failure

2016 ◽  
Vol 35 (6) ◽  
pp. 432-440 ◽  
Author(s):  
K. S. Prasanna ◽  
Ashish Goel ◽  
G. Jayakumar Amirtharaj ◽  
Anup Ramachandran ◽  
K. A. Balasubramanian ◽  
...  
Keyword(s):  
Liver Failure ◽  
Von Willebrand Factor ◽  
Chronic Liver ◽  
Chronic Liver Failure ◽  
Hospital Survival ◽  
Von Willebrand ◽  
Willebrand Factor

scholarly journals Reliability of Plasma Von Willebrand Factor Antigen in Prediction of Esophageal Varices in Patients with Liver Cirrhosis

2015 ◽  
Vol 05 (06) ◽  
pp. 49-57
Author(s):  
Hasan Sedeek Mahmoud ◽  
Ali A. Ghweil ◽  
Shamardan E. Bazeed ◽  
Hanan M. Fayed ◽  
Mona M. Abdel Meguid
Keyword(s):  
Liver Cirrhosis ◽  
Von Willebrand Factor ◽  
Esophageal Varices ◽  
Von Willebrand Factor Antigen ◽  
Von Willebrand ◽  
Willebrand Factor ◽  
Factor Antigen
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