Sequential therapy including regorafenib for unresectable hepatocellular carcinoma: Effect of early relative changes in hepatic functional reserve after regorafenib administration on prognosis

2021 ◽  
Author(s):  
Hironori Ochi ◽  
Joji Tani ◽  
Tetsu Tomonari ◽  
Tatsuya Taniguchi ◽  
Yohei Koizumi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Sequential Therapy ◽  
Hepatic Functional Reserve ◽  
Functional Reserve ◽  
Unresectable Hepatocellular Carcinoma

Liver Damage after Transarterial Chemoembolization without Embolizing Agent in Unresectable Hepatocellular Carcinoma

2003 ◽  
Vol 89 (3) ◽  
pp. 285-287 ◽  
Author(s):  
Stefano Puleo ◽  
Letizia Mauro ◽  
Giuseppe Gagliano ◽  
Rosario Lombardo ◽  
Giovanni Li Destri ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Transarterial Chemoembolization ◽  
Alpha Fetoprotein ◽  
Total Serum ◽  
Advanced Hepatocellular Carcinoma ◽  
Significant Finding ◽  
Safe Procedure ◽  
Hepatic Functional Reserve ◽  
Neoplastic Tissue ◽  
Functional Reserve

Aim and Background Transarterial chemoembolization represents a therapy for hepatocellular carcinoma, but in cirrhotic patients affected by large or multifocal HCC with poor hepatic functional reserve, the procedure can damage normal parenchyma. We analyzed the effects on hepatic function of a modified chemoembolization consisting of ethiodized oil (Lipiodol Ultra Fluid) and epirubicin without gelatine sponge (C-LIP). Methods Of 90 patients with hepatocellular carcinoma observed from January 1995 to December 1999, 16 with a diagnosis of advanced (large or multifocal) disease underwent 19 C-LIP. The 30th post-C-LIP day was considered as a checkpoint of the biochemical parameters for a possible hepatic failure. The value of alpha-fetoprotein and the clinical finding of ascites were also considered after 30 days. Results Postoperative values of serum aspartate aminotrasferases, as well as alanine aminotransferase, were significantly higher than preoperative values (P = 0.002 and P = 0.019, respectively) (Table 1). In all patients, there was a significant increase in postoperative total serum bilirubin (P = 0.003). Statistical analysis showed a significant finding of postoperative ascites (P = 0.035) and the effectiveness of C-LIP on neoplastic tissue by a decrease of alpha-fetoprotein values at 30 days (P = 0.067). Conclusions Transcatether arterial chemoembolization could represent an effective therapy against multifocal or advanced hepatocellular carcinoma, and its effectiveness is probably not decreased by using a modified procedure without embolizing agent (C-LIP). However, even when performing such a safe procedure, the hepatic functional reserve of the individual patient needs to be accurately evaluated in order to avoid liver failure.

scholarly journals EXPERIENCE WITH HEPATECTOMY AFTER THE ACTIVATION OF DECREASED HEPATIC FUNCTIONAL RESERVE IN PATIENTS WITH HEPATOCELLULAR CARCINOMA

1993 ◽  
Vol 54 (6) ◽  
pp. 1617-1623
Author(s):  
Akio ISHIKAWA ◽  
Katashi FUKAO ◽  
Akira OSADA ◽  
Katsuhisa TSUJI ◽  
Yuji YAMAMOTO ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatic Functional Reserve ◽  
Functional Reserve

Changes in hepatic functional reserve after transcatheter embolization of hepatocellular carcinoma

1988 ◽  
Vol 6 (3) ◽  
pp. 332-336 ◽  
Author(s):  
S. Miyoshi ◽  
Y. Minami ◽  
S. Kawata ◽  
Y. Imai ◽  
R. Saitoh ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Transcatheter Embolization ◽  
Hepatic Functional Reserve ◽  
Functional Reserve

Important Clinical Factors in Sequential Therapy Including Lenvatinib against Unresectable Hepatocellular Carcinoma

Oncology ◽  
2019 ◽  
Vol 97 (5) ◽  
pp. 277-285 ◽  
Author(s):  
Atsushi Hiraoka ◽  
Takashi Kumada ◽  
Masanori Atsukawa ◽  
Masashi Hirooka ◽  
Kunihiko Tsuji ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Sequential Therapy ◽  
Clinical Factors ◽  
Unresectable Hepatocellular Carcinoma
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