Angiopoietin‐like protein 4 deficiency augments liver fibrosis in liver diseases such as nonalcoholic steatohepatitis in mice through enhanced free cholesterol accumulation in hepatic stellate cells

2020 ◽  
Author(s):  
Toshiaki Teratani ◽  
Kengo Tomita ◽  
Akinori Wada ◽  
Nao Sugihara ◽  
Masaaki Higashiyama ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Nonalcoholic Steatohepatitis ◽  
Hepatic Stellate Cells ◽  
Liver Diseases ◽  
Free Cholesterol ◽  
Stellate Cells ◽  
Cholesterol Accumulation

Free cholesterol accumulation in hepatic stellate cells: Mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice

Hepatology ◽  
2013 ◽  
Vol 59 (1) ◽  
pp. 154-169 ◽  
Author(s):  
Kengo Tomita ◽  
Toshiaki Teratani ◽  
Takahiro Suzuki ◽  
Motonori Shimizu ◽  
Hirokazu Sato ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Nonalcoholic Steatohepatitis ◽  
Hepatic Stellate Cells ◽  
Free Cholesterol ◽  
Stellate Cells ◽  
Cholesterol Accumulation

Vitamin A-coupled liposome system targeting free cholesterol accumulation in hepatic stellate cells offers a beneficial therapeutic strategy for liver fibrosis

2018 ◽  
Vol 48 (5) ◽  
pp. 397-407 ◽  
Author(s):  
Hirotaka Furuhashi ◽  
Kengo Tomita ◽  
Toshiaki Teratani ◽  
Motonori Shimizu ◽  
Makoto Nishikawa ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Vitamin A ◽  
Hepatic Stellate Cells ◽  
Free Cholesterol ◽  
Therapeutic Strategy ◽  
Stellate Cells ◽  
Cholesterol Accumulation ◽  
Liposome System

Acyl-CoA:cholesterol acyltransferase 1 mediates liver fibrosis by regulating free cholesterol accumulation in hepatic stellate cells

2014 ◽  
Vol 61 (1) ◽  
pp. 98-106 ◽  
Author(s):  
Kengo Tomita ◽  
Toshiaki Teratani ◽  
Takahiro Suzuki ◽  
Motonori Shimizu ◽  
Hirokazu Sato ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Hepatic Stellate Cells ◽  
Free Cholesterol ◽  
Stellate Cells ◽  
Cholesterol Accumulation

scholarly journals Lipoprotein Lipase Up‐regulation in Hepatic Stellate Cells Exacerbates Liver Fibrosis in Nonalcoholic Steatohepatitis in Mice

2019 ◽  
Vol 3 (8) ◽  
pp. 1098-1112 ◽  
Author(s):  
Toshiaki Teratani ◽  
Kengo Tomita ◽  
Hirotaka Furuhashi ◽  
Nao Sugihara ◽  
Masaaki Higashiyama ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Lipoprotein Lipase ◽  
Nonalcoholic Steatohepatitis ◽  
Hepatic Stellate Cells ◽  
Stellate Cells

A High-Cholesterol Diet Exacerbates Liver Fibrosis in Mice via Accumulation of Free Cholesterol in Hepatic Stellate Cells

2012 ◽  
Vol 142 (1) ◽  
pp. 152-164.e10 ◽  
Author(s):  
Toshiaki Teratani ◽  
Kengo Tomita ◽  
Takahiro Suzuki ◽  
Tetsuya Oshikawa ◽  
Hirokazu Yokoyama ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Hepatic Stellate Cells ◽  
Free Cholesterol ◽  
Stellate Cells ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol

scholarly journals Niemann-Pick Type C2 Protein Mediates Hepatic Stellate Cells Activation by Regulating Free Cholesterol Accumulation

2016 ◽  
Vol 17 (7) ◽  
pp. 1122 ◽  
Author(s):  
Yuh-Ching Twu ◽  
Tzong-Shyuan Lee ◽  
Yun-Lian Lin ◽  
Shih-Ming Hsu ◽  
Yuan-Hsi Wang ◽  
...  
Keyword(s):  
Hepatic Stellate Cells ◽  
Free Cholesterol ◽  
Stellate Cells ◽  
Cholesterol Accumulation ◽  
Niemann Pick

1061 HIGH CHOLESTEROL DIETS EXACERBATE MOUSE LIVER FIBROSIS THROUGH BUILDUP OF FREE CHOLESTEROL IN HEPATIC STELLATE CELLS

2011 ◽  
Vol 54 ◽  
pp. S421
Author(s):  
K. Tomita ◽  
T. Teratani ◽  
T. Suzuki ◽  
T. Oshikawa ◽  
H. Yokoyama ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Hepatic Stellate Cells ◽  
Mouse Liver ◽  
Free Cholesterol ◽  
Stellate Cells ◽  
High Cholesterol

Su1499 - Lipoprotein Lipase in Hepatic Stellate Cells Exaggerates Liver Fibrosis in Nonalcoholic Steatohepatitis in Mice

2018 ◽  
Vol 154 (6) ◽  
pp. S-1159
Author(s):  
Nao Sugihara ◽  
Kengo Tomita ◽  
Hirotaka Furuhashi ◽  
Takeshi Takajo ◽  
Chie Kurihara ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Lipoprotein Lipase ◽  
Nonalcoholic Steatohepatitis ◽  
Hepatic Stellate Cells ◽  
Stellate Cells
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