Outcomes of lactulose plus branched‐chain amino acid infusion and lactulose alone for hepatic encephalopathy: A retrospective cohort study using a national inpatient database

2020 ◽  
Vol 50 (6) ◽  
pp. 693-703
Author(s):  
Akira Okada ◽  
Hayato Yamana ◽  
Satoko Yamaguchi ◽  
Kayo Ikeda Kurakawa ◽  
Hiroki Matsui ◽  
...  
Keyword(s):  
Cohort Study ◽  
Hepatic Encephalopathy ◽  
Amino Acid ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Acid Infusion ◽  
Amino Acid Infusion ◽  
Branched Chain Amino Acid ◽  
Branched Chain ◽  
Inpatient Database

Effects of branched-chain amino acid infusion on protein metabolism in rats with acute hepatic failure

Hepatology ◽  
1995 ◽  
Vol 22 (1) ◽  
pp. 291-296 ◽  
Author(s):  
Yoshiyuki Miwa ◽  
Masahiko Kato ◽  
Hisataka Moriwaki ◽  
Masataka Okuno ◽  
Jun'ichi Sugihara ◽  
...  
Keyword(s):  
Amino Acid ◽  
Hepatic Failure ◽  
Protein Metabolism ◽  
Acute Hepatic Failure ◽  
Acid Infusion ◽  
Amino Acid Infusion ◽  
Branched Chain Amino Acid ◽  
Branched Chain

scholarly journals Clinical significance of branched Chain amino acid infusion during the treatments of patients with fulminant hepatitis

Kanzo ◽  
1979 ◽  
Vol 20 (7) ◽  
pp. 702-713 ◽  
Author(s):  
Akiharu WATANABE ◽  
Toshihiro HIGASHI ◽  
Shosaku HAYASHI ◽  
Takahiro OBATA ◽  
Hideo NAGASHIMA
Keyword(s):  
Amino Acid ◽  
Clinical Significance ◽  
Fulminant Hepatitis ◽  
Acid Infusion ◽  
Amino Acid Infusion ◽  
Branched Chain Amino Acid ◽  
Branched Chain

Effect of Infused Branched-Chain Amino Acids on Muscle and Whole-Body Amino Acid Metabolism in Man

1990 ◽  
Vol 79 (5) ◽  
pp. 457-466 ◽  
Author(s):  
Rita J. Louard ◽  
Eugene J. Barrett ◽  
Robert A. Gelfand
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Muscle Protein ◽  
Muscle Protein Synthesis ◽  
Branched Chain Amino Acids ◽  
Whole Body ◽  
Acid Infusion ◽  
Amino Acid Infusion ◽  
Branched Chain Amino Acid ◽  
Branched Chain

1. Using the forearm balance method, together with systemic infusions of l-[ring-2,6-3H]phenylalanine and l-[1-14C]leucine, we examined the effects of infused branched-chain amino acids on whole-body and skeletal muscle amino acid kinetics in 10 postabsorptive normal subjects; 10 control subjects received only saline. 2. Infusion of branched-chain amino acids caused a four-fold rise in arterial branched-chain amino acid levels and a two-fold rise in branched-chain keto acids; significant declines were observed in circulating levels of most other amino acids, including phenylalanine, which fell by 34%. Plasma insulin levels were unchanged from basal levels (8 ± 1 μ-units/ml). 3. Whole-body phenylalanine flux, an index of proteolysis, was significantly suppressed by branched-chain amino acid infusion (P < 0.002), and forearm phenylalanine production was also inhibited (P < 0.03). With branched-chain amino acid infusion total leucine flux rose, with marked increments in both oxidative and non-oxidative leucine disposal (P < 0.001). Proteolysis, as measured by endogenous leucine production, showed a modest 12% decrease, although this was not significant when compared with saline controls. The net forearm balance of leucine and other branched-chain amino acids changed from a basal net output to a marked net uptake (P < 0.001) during branched-chain amino acid infusion, with significant stimulation of local leucine disposal. Despite the rise in whole-body non-oxidative leucine disposal, and in forearm leucine uptake and disposal, forearm phenylalanine disposal, an index of muscle protein synthesis, was not stimulated by infusion of branched-chain amino acids. 4. The results suggest that in normal man branched-chain amino acid infusion suppresses skeletal muscle proteolysis independently of any rise of plasma insulin. Muscle branched-chain amino acid uptake rose dramatically in the absence of any apparent increase in muscle protein synthesis, as measured by phenylalanine disposal, or in branched-chain keto acid release. Thus, an increase in muscle branched-chain amino acid concentrations and/ or local branched-chain amino acid oxidation must account for the increased disposal of branched-chain amino acids.

Effect of Glucose and/or Branched Chain Amino Acid Infusion on Plasma Amino Acid Imbalance in Chronic Liver Failure

1981 ◽  
Vol 5 (5) ◽  
pp. 414-419 ◽  
Author(s):  
Filippo Rossi-Fanelli ◽  
Mario Angelico ◽  
Carlo Cangiano ◽  
Antonia Cascino ◽  
Riccardo Capocaccia ◽  
...  
Keyword(s):  
Amino Acid ◽  
Liver Failure ◽  
Plasma Amino Acid ◽  
Chronic Liver Failure ◽  
Acid Infusion ◽  
Amino Acid Infusion ◽  
Branched Chain Amino Acid ◽  
Amino Acid Imbalance ◽  
Branched Chain ◽  
Effect Of Glucose
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