Associations among liver disease, serum lipid profile, body mass index, ketonuria, meal skipping, and the alcohol dehydrogenase‐1B and aldehyde dehydrogenase‐2 genotypes in Japanese men with alcohol dependence

2020 ◽  
Vol 50 (5) ◽  
pp. 565-577 ◽  
Author(s):  
Akira Yokoyama ◽  
Nobuhito Taniki ◽  
Nobuhiro Nakamoto ◽  
Kengo Tomita ◽  
Sachiko Hara ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Liver Disease ◽  
Alcohol Dehydrogenase ◽  
Alcohol Dependence ◽  
Lipid Profile ◽  
Aldehyde Dehydrogenase ◽  
Serum Lipid ◽  
Aldehyde Dehydrogenase 2 ◽  
Japanese Men ◽  
Meal Skipping

scholarly journals Ethnic Differences in Serum Levels of microRNAs Potentially Regulating Alcohol Dehydrogenase 1B and Aldehyde Dehydrogenase 2

2021 ◽  
Vol 10 (16) ◽  
pp. 3678
Author(s):  
Ichiro Wakabayashi ◽  
Harald Sourij ◽  
Yoko Sotoda ◽  
Takashi Daimon ◽  
Klaus Groschner ◽  
...  
Keyword(s):  
Alcohol Dehydrogenase ◽  
Blood Vessel ◽  
Aldehyde Dehydrogenase ◽  
Ethnic Differences ◽  
Ethnic Difference ◽  
Serum Levels ◽  
Aldehyde Dehydrogenase 2 ◽  
Japanese Men ◽  
Prediction Tools ◽  
Significant Difference

Ethnic difference is known in genetic polymorphisms of aldehyde dehydrogenase 2 (ALDH2) and alcohol dehydrogenase 1B (ADH1B), which cause Asian flushing by blood vessel dilation due to accumulation of acetaldehyde. We investigated ethnic differences in microRNAs (miRNAs) related to ALDH2 and ADH1B. miRNA levels in serum were totally analyzed by using miRNA oligo chip arrays and compared in Austrian and Japanese middle-aged men. There were no ALDH2- and ADH1B-related miRNAs that had previously been reported in humans and that showed significantly different serum levels between Austrian and Japanese men. With the use of miRNA prediction tools, we identified four and five miRNAs that were predicted to target ALDH2 and ADH1B, respectively, and they had expression levels high enough for comparison. Among the ADH1B-related miRNAs, miR-150-3p, -3127-5p and -4314 were significantly higher and miR-3151-5p was significantly lower in Austrian compared with Japanese men, while no significant difference was found for miR-449b-3p. miR-150-3p and miR-4314 showed relatively high fold changes (1.5 or higher). The levels of ALDH2-related miRNAs (miR-30d-5p, -6127, -6130 and -6133) were not significantly different between the countries. miR-150-3p and miR-4314 are candidates of miRNAs that may be involved in the ethnic difference in sensitivity to alcohol through modifying the expression of ADH1B.

scholarly journals DIFFERENCES IN BODY MASS INDEX AND SERUM LIPID PROFILE AMONG VEGETARIANS & NON VEGETARIANS

2013 ◽  
Vol 2 (35) ◽  
pp. 6766-6771
Author(s):  
Suja P ◽  
Shrinidhi Shrinidhi ◽  
Prarthana K G ◽  
Bharath T
Keyword(s):  
Body Mass Index ◽  
Lipid Profile ◽  
Body Mass ◽  
Serum Lipid ◽  
Serum Lipid Profile

Alcohol Dehydrogenase Isoenzymes and Aldehyde Dehydrogenase Activity in the Serum of Patients with Non-alcoholic Fatty Liver Disease

2018 ◽  
Vol 38 (7) ◽  
pp. 4005-4009 ◽  
Author(s):  
WOJCIECH JELSKI ◽  
BLANKA WOLSZCZAK-BIEDRZYCKA ◽  
ELŻBIETA ZASIMOWICZ-MAJEWSKA ◽  
KAROLINA ORYWAL ◽  
TADEUSZ WOJCIECH LAPINSKI ◽  
...  
Keyword(s):  
Liver Disease ◽  
Alcohol Dehydrogenase ◽  
Fatty Liver ◽  
Dehydrogenase Activity ◽  
Aldehyde Dehydrogenase ◽  
Fatty Liver Disease ◽  
Alcohol Dehydrogenase Isoenzymes ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease ◽  
Aldehyde Dehydrogenase Activity

Abstract P128: Serum Lipid Levels at Adolescence can Predict Adult Dyslipidemia in South Korea - The Kangwha Study

Circulation ◽  
2017 ◽  
Vol 135 (suppl_1) ◽  
Author(s):  
Jung H Lee ◽  
Hyeon C Kim ◽  
Dae R Kang ◽  
Il Suh
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Logistic Regression ◽  
South Korea ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Serum Lipid ◽  
Hdl Cholesterol ◽  
Multiple Logistic Regression ◽  
Auc Value

Introduction: Several studies have examined tracking pattern of lipid profile level during long follow-up periods in Western countries. However, there have been few such studies in East Asia. Hypothesis: We assessed the hypothesis that there exists tracking pattern of lipid profile level from adolescence to adulthood, and lipid measurements in adolescence can predict adult dyslipidemia in South Korea. Methods: The Kangwha Study was a community-based prospective cohort study that started in 1986 in Kangwha County, South Korea . A total of 400 participants (54% women) whose serum total cholesterol, triglyceride, and high density lipoprotein (HDL) cholesterol level were measured at least once during adolescence (1992-1996), and repeatedly measured at least once during adulthood (2005-2015) were enrolled in our study. Body mass index, waist circumstance, and blood pressure were measured at all measurements. Family history of cardiovascular disease, smoking history, and presence of adult dyslipidemia were checked at adulthood. The tracking pattern of lipid profile level was determined by tracking coefficients (low: <0.30; moderate: 0.30-0.59; moderately high: 0.60-0.89; high: ≥0.90). The tracking coefficients were calculated by Generalized Estimating Equation. The predictability of adult dyslipidemia was assessed by multiple logistic regression and area under curve (AUC) value. Additional analyses were performed to find out whether repeated lipid measurements during adolescence can enhance the predictability of adult dyslipidemia or not. Results: The presence of adult dyslipidemia was 26.3% (105 of 400). Mean age of study participants at enrollment is 13.8 years (SD, 1.6 years), and that at adulthood is 30.1 years (SD, 3.7 years). When adjusted for age, body mass index, waist circumstance, and blood pressure, the tracking coefficient of total cholesterol was 0.59 (95% confidence interval (CI), 0.54-0.63), that of triglyceride was 0.39 (95% CI, 0.28-0.49), and that of HDL cholesterol was 0.51 (95% CI, 0.46-0.55). The AUC value of our multiple logistic regression model on adult dyslipidemia without lipid profile levels at adolescence was 0.77 (95% CI, 0.72-0.83), and that with lipid profile levels at adolescence was 0.80 (95% CI, 0.75-0.85). P value for AUC comparison was significant (p=0.02). In additional analyses, using the average lipid profile levels in multiple lipid measurements at adolescence did not significantly improve the AUC value (p>0.09). Conclusion: In conclusion, moderate tracking patterns of serum lipid profile level were shown in this study. Serum lipid profile measurements at adolescence could help the prediction of adult dyslipidemia. The results of this study supported the need of lipid profile screening at adolescence.

Body mass index and serum lipid profile: Association with atopic dermatitis in a paediatric population

2019 ◽  
Vol 61 (1) ◽  
Author(s):  
Pedro Jesús Agón‐Banzo ◽  
Rosalía Sanmartin ◽  
Ana Julia García‐Malinis ◽  
Ángela Hernández‐Martín ◽  
José Puzo ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Atopic Dermatitis ◽  
Lipid Profile ◽  
Body Mass ◽  
Serum Lipid ◽  
Paediatric Population ◽  
Serum Lipid Profile

Association Of Body Mass Index And Serum Lipid Profile Among Middle-Aged Lithuanian Men

2019 ◽  
Vol 287 ◽  
pp. e134-e135
Author(s):  
Z. Petrulioniene ◽  
S. Kutkiene ◽  
J. Staigyte ◽  
U. Gargalskaite ◽  
E. Rinkuniene ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Lipid Profile ◽  
Body Mass ◽  
Serum Lipid ◽  
Serum Lipid Profile ◽  
Middle Aged

Relationship Between Body Mass Index And Serum Lipid Profile Among Middle-Aged Lithuanian Women

2019 ◽  
Vol 287 ◽  
pp. e134
Author(s):  
Z. Petrulioniene ◽  
S. Kutkiene ◽  
J. Staigyte ◽  
U. Gargalskaite ◽  
E. Rinkuniene ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Lipid Profile ◽  
Body Mass ◽  
Serum Lipid ◽  
Serum Lipid Profile ◽  
Middle Aged
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