Branched chain amino acids: A factor for zone 3 steatosis in non‐alcoholic fatty liver disease

2019 ◽  
Vol 49 (8) ◽  
pp. 841-843
Author(s):  
Takumi Kawaguchi ◽  
Takuji Torimura
Keyword(s):  
Amino Acids ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Branched Chain Amino Acids ◽  
Alcoholic Fatty Liver ◽  
Branched Chain ◽  
Alcoholic Fatty Liver Disease

scholarly journals Non-Alcoholic Fatty Liver Disease and Risk of Incident Type 2 Diabetes: Role of Circulating Branched-Chain Amino Acids

Nutrients ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 705 ◽  
Author(s):  
Eline van den Berg ◽  
Jose Flores-Guerrero ◽  
Eke Gruppen ◽  
Martin de Borst ◽  
Justyna Wolak-Dinsmore ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Amino Acids ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Branched Chain Amino Acids ◽  
Elevated Plasma ◽  
Alcoholic Fatty Liver ◽  
Branched Chain ◽  
Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease (NAFLD) is likely to be associated with elevated plasma branched-chain amino acids (BCAAs) and may precede the development of type 2 diabetes (T2D). We hypothesized that BCAAs may be involved in the pathogenesis of T2D attributable to NAFLD and determined the extent to which plasma BCAAs influence T2D development in NAFLD. We evaluated cross-sectional associations of NAFLD with fasting plasma BCAAs (nuclear magnetic resonance spectroscopy), and prospectively determined the extent to which the influence of NAFLD on incident T2D is attributable to BCAA elevations. In the current study, 5791 Prevention of REnal and Vascular ENd-stage Disease (PREVEND) cohort participants without T2D at baseline were included. Elevated fatty liver index (FLI) ≥60, an algorithm based on triglycerides, gamma-glutamyltransferase, body mass index (BMI) and waist circumference, was used as proxy of NAFLD. Elevated FLI ≥ 60 was present in 1671 (28.9%) participants. Cross-sectionally, BCAAs were positively associated with FLI ≥ 60 (β = 0.208, p < 0.001). During a median follow-up of 7.3 years, 276 participants developed T2D, of which 194 (70.2%) had an FLI ≥ 60 (log-rank test, p < 0.001). Cox regression analyses revealed that both FLI ≥60 (hazard ratio (HR) 3.46, 95% CI 2.45–4.87, p < 0.001) and higher BCAA levels (HR 1.19, 95% CI 1.03–1.37, p = 0.01) were positively associated with incident T2D. Mediation analysis showed that the association of FLI with incident T2D was in part attributable to elevated BCAAs (proportion mediated 19.6%). In conclusion, both elevated FLI and elevated plasma BCAA levels are associated with risk of incident T2D. The association of NAFLD with T2D development seems partly mediated by elevated BCAAs.

Effect of specific amino acids on hepatic lipid metabolism in fructose-induced non-alcoholic fatty liver disease

2016 ◽  
Vol 35 (1) ◽  
pp. 175-182 ◽  
Author(s):  
Prasanthi Jegatheesan ◽  
Stéphanie Beutheu ◽  
Gabrielle Ventura ◽  
Gilles Sarfati ◽  
Esther Nubret ◽  
...  
Keyword(s):  
Amino Acids ◽  
Lipid Metabolism ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Hepatic Lipid Metabolism ◽  
Alcoholic Fatty Liver ◽  
Hepatic Lipid ◽  
Alcoholic Fatty Liver Disease

Pancrelipase with branched-chain amino acids for preventing nonalcoholic fatty liver disease after pancreaticoduodenectomy

2015 ◽  
Vol 51 (1) ◽  
pp. 55-62 ◽  
Author(s):  
Shintaro Yamazaki ◽  
Tadatoshi Takayama ◽  
Tokio Higaki ◽  
Masamichi Moriguchi ◽  
Nao Yoshida ◽  
...  
Keyword(s):  
Amino Acids ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Branched Chain Amino Acids ◽  
Nonalcoholic Fatty Liver ◽  
Branched Chain

1052 D-Amino Acids as a Novel Link between Gut Microbiota and Non-Alcoholic Fatty Liver Disease

2016 ◽  
Vol 150 (4) ◽  
pp. S1056
Author(s):  
Wensheng Liu ◽  
Susan S. Baker ◽  
Ricardo A. Arbizu ◽  
Aswad Jackson ◽  
Robert D. Baker ◽  
...  
Keyword(s):  
Amino Acids ◽  
Liver Disease ◽  
Gut Microbiota ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease
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