Stevia prevents experimental cirrhosis by reducing hepatic myofibroblasts and modulating molecular profibrotic pathways

2018 ◽  
Vol 49 (2) ◽  
pp. 212-223 ◽  
Author(s):  
Erika Ramos-Tovar ◽  
Laura D. Buendia-Montaño ◽  
Silvia Galindo-Gómez ◽  
Erika Hernández-Aquino ◽  
Víctor Tsutsumi ◽  
...  
Keyword(s):  
Experimental Cirrhosis

Pathogenesis of solute-free water retention in experimental ascitic cirrhosis: is vasopressin the only culprit?

2015 ◽  
Vol 130 (2) ◽  
pp. 117-124 ◽  
Author(s):  
Giovanni Sansoè ◽  
Manuela Aragno ◽  
Raffaella Mastrocola ◽  
Maurizio Parola
Keyword(s):  
Antidiuretic Hormone ◽  
Water Retention ◽  
Renal Excretion ◽  
Free Water ◽  
Experimental Cirrhosis ◽  
Advanced Cirrhosis ◽  
Adrenoceptor Agonists ◽  
Sympatholytic Agents ◽  
Dilutional Hyponatraemia

Adrenergic hyper-function reduces renal excretion of water. In advanced cirrhosis, hypersecretion of vasopressin (antidiuretic hormone or ADH) is considered the cause of dilutional hyponatraemia. We show that in experimental cirrhosis sympatholytic agents (α2A-adrenoceptor agonists) are as effective as V2 antagonists to blunt water retention.

Overexpression of kidney neutral endopeptidase (EC 3.4.24.11) and renal function in experimental cirrhosis

2006 ◽  
Vol 290 (6) ◽  
pp. F1337-F1343 ◽  
Author(s):  
G. Sansoè ◽  
M. Aragno ◽  
R. Mastrocola ◽  
J. C. Cutrin ◽  
S. Silvano ◽  
...  
Keyword(s):  
Arterial Pressure ◽  
Specific Inhibitor ◽  
Free Water ◽  
Plasma Renin ◽  
Neutral Endopeptidase ◽  
Experimental Cirrhosis ◽  
Proximal Tubule Cells ◽  
Advanced Cirrhosis ◽  
Normal Humans ◽  
Renal Proximal Tubule Cells

Neutral endopeptidase degrades atrial natriuretic peptide (ANP) and bradykinin and may generate endothelin-1 from big-endothelin. In advanced cirrhosis, sodium retention is accompanied by elevated plasma ANP levels, and infusion of ANP causes hypotension, but in normal humans increasing the concentration of ANP through the inhibition of neutral endopeptidase, localized in renal proximal tubule cells, causes natriuresis without any arterial pressure drop. The purpose of this study was the assessment of kidney neutral endopeptidase expression and responses to candoxatrilat (a specific inhibitor of this enzyme) in rats with CCl4-induced cirrhosis. Two groups of control rats ( n = 5) were injected with vehicle or 3 mg/kg candoxatrilat. Three groups of cirrhotic rats with ascites ( n = 10) received vehicle alone or 3 or 10 mg/kg candoxatrilat. In cirrhotic rats, Western blot analysis revealed a 170% increase in renal neutral endopeptidase protein content ( P < 0.03), mainly in the proximal nephron and macula densa, and both candoxatrilat dosages increased plasma ANP levels, urinary volume, and urinary excretion of sodium, ANP, and cGMP compared with vehicle alone (all P < 0.03). Candoxatrilat (10 mg/kg) also reduced tubular solute-free water reabsorption ( P < 0.03) in cirrhotic rats, but renal blood flow, arterial pressure, and plasma renin activity were unaffected. Neutral endopeptidase inhibition has natriuretic and aquaretic actions in cirrhosis without any effect on blood pressure and kidney perfusion due to a significant overexpression of this enzyme in renal cortex.

Prolonged bleeding time in experimental cirrhosis: role of nitric oxide

1999 ◽  
Vol 30 (3) ◽  
pp. 456-460 ◽  
Author(s):  
Liliana Albornoz ◽  
Juan Carlos Bandi ◽  
Juan Carlos Otaso ◽  
Oscar Laudanno ◽  
Ricardo Mastai
Keyword(s):  
Nitric Oxide ◽  
Bleeding Time ◽  
Experimental Cirrhosis ◽  
Prolonged Bleeding ◽  
Prolonged Bleeding Time

Impaired responsiveness to angiotensin II in experimental cirrhosis: Role of nitric oxide

Hepatology ◽  
1993 ◽  
Vol 18 (2) ◽  
pp. 367-372 ◽  
Author(s):  
Anna Castro ◽  
Wladimiro Jiménez ◽  
Joan Clária ◽  
Josefa Ros ◽  
Josep Maria Martínez ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Angiotensin Ii ◽  
Experimental Cirrhosis

Collagenolytic activity in experimental cirrhosis of the liver

1987 ◽  
Vol 47 (3) ◽  
pp. 300-308 ◽  
Author(s):  
Ruy Perez-Tamayo ◽  
Irmgard Montfort ◽  
Elvira Gonzalez
Keyword(s):  
Cirrhosis Of The Liver ◽  
Collagenolytic Activity ◽  
Experimental Cirrhosis

Impaired drug metabolism in experimental cirrhosis in the rat

1978 ◽  
Vol 27 (22) ◽  
pp. 2577-2581 ◽  
Author(s):  
Jfan-Pierre Villeneuve ◽  
Alastair J.J Wood ◽  
David G. Shand ◽  
Lowell Rogers ◽  
Robert A. Branch
Keyword(s):  
Drug Metabolism ◽  
Experimental Cirrhosis
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