High platelet counts increase metastatic risk in huge hepatocellular carcinoma undergoing transarterial chemoembolization

2016 ◽  
Vol 46 (10) ◽  
pp. 1028-1036 ◽  
Author(s):  
Tong-Chun Xue ◽  
Ning-Ling Ge ◽  
Xin Xu ◽  
Fan Le ◽  
Bo-Heng Zhang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Transarterial Chemoembolization ◽  
Platelet Counts ◽  
Huge Hepatocellular Carcinoma ◽  
Metastatic Risk

scholarly journals Partial Splenic Embolization with Transarterial Chemoembolization in Patients with Hepatocellular Carcinoma Accompanied by Thrombocytopenia

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Yoshihiko Ooka ◽  
Tetsuhiro Chiba ◽  
Sadahisa Ogasawara ◽  
Tenyu Motoyama ◽  
Eiichiro Suzuki ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Failure ◽  
Transarterial Chemoembolization ◽  
Systemic Chemotherapy ◽  
Serum Levels ◽  
Severe Thrombocytopenia ◽  
Partial Splenic Embolization ◽  
Long Term Effects ◽  
Platelet Counts ◽  
Splenic Embolization

Background. Thrombocytopenia often makes the introduction of systemic treatment difficult in patients with cirrhosis and hepatocellular carcinoma (HCC). We retrospectively evaluated the long-term effects of partial splenic embolization (PSE) with transarterial chemoembolization (TACE) in patients with HCC patients accompanied by thrombocytopenia.Patients and Methods. Twenty-one patients with HCC complicated by severe thrombocytopenia (platelet count, <5.0 × 104/mm3) were treated with PSE and TACE. Both the safety and platelet-increasing effect was evaluated in these patients.Results. Seventeen of 21 patients (81.0%) showed increased platelet counts to ≥5.0 × 104/mm3. Subsequently, 13 patients (61.9%) successfully received systemic chemotherapy. Platelet counts and serum levels of total bilirubin, as well as neutrophil counts, improved significantly one month after treatment. However, serum levels of albumin and hemoglobin decreased significantly one month after treatment. Severe adverse events, including acute liver failure and portal vein thrombus, were observed in two patients.Conclusion. PSE with selective TACE made it possible for patients with HCC and severe thrombocytopenia to receive systemic chemotherapy. Although PSE with TACE was safe and tolerable for most patients, the extent of PSE with TACE in a wide area of the liver may increase the risk for fatal liver failure.

scholarly journals Gallbladder Perforation after Transarterial Chemoembolization in a Patient with a Huge Hepatocellular Carcinoma

2020 ◽  
Vol 75 (6) ◽  
pp. 351-355
Author(s):  
Min Young Son ◽  
Byung Hoon Han ◽  
Sang Uk Lee ◽  
Byung Cheol Yun ◽  
Kwang Il Seo ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Transarterial Chemoembolization ◽  
Gallbladder Perforation ◽  
Huge Hepatocellular Carcinoma

scholarly journals Huge Hepatocellular Carcinoma Treated with Radical Hepatectomy after Drug-eluting Bead Transarterial Chemoembolization

2019 ◽  
Vol 58 (8) ◽  
pp. 1103-1110 ◽  
Author(s):  
Masashi Fujita ◽  
Ken Okai ◽  
Manabu Hayashi ◽  
Kazumichi Abe ◽  
Atsushi Takahashi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Transarterial Chemoembolization ◽  
Drug Eluting ◽  
Huge Hepatocellular Carcinoma
Sign in / Sign up

Export Citation Format

Share Document