Diagnostic value of miRNA-96-5p/3p in dysplastic nodules and well-differentiated small hepatocellular carcinoma

2016 ◽  
Vol 46 (8) ◽  
pp. 784-793 ◽  
Author(s):  
Hui Zhang ◽  
Ai-Yan Xing ◽  
Ran-Ran Ma ◽  
Ya-Wen Wang ◽  
Yu-Hui Liu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Diagnostic Value ◽  
Small Hepatocellular Carcinoma ◽  
Dysplastic Nodules ◽  
Well Differentiated

scholarly journals Diagnostic Value of Clusterin Immunostaining in Hepatocellular Carcinoma

2020 ◽  
Author(s):  
Yuan Li ◽  
Fangfang Liu ◽  
Wendi Zhou ◽  
Sharon Zhang ◽  
Peiguo Chu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Expression Pattern ◽  
Staining Pattern ◽  
Hepatocellular Adenoma ◽  
Normal Liver ◽  
Diagnostic Value ◽  
Tissue Samples ◽  
Regenerative Nodules ◽  
Well Differentiated ◽  
Mass Lesions

Abstract Background Histologic distinction between well differentiated hepatocellular carcinoma (HCC) and benign hepatocellular mass lesions is a known challenging. Existing biomarkers are of limited diagnostic value. Our previous studies observed an enhanced canalicular expression pattern of clusterin (CLU) in HCC, which was not observed in benign hepatocellular mass lesions such as hepatocellular adenoma. The aim of this study was to further investigate its diagnostic value for HCC by examining the expression pattern of CLU in a large number of non-hepatocellular tumors, and by comparing it with two other commonly used hepatocellular markers pCEA and CD10 that also show a canalicular staining pattern in HCC.Methods Enhanced canalicular staining patterns of CLU, pCEA and CD10 were analyzed on 54 surgically resected well to moderately differentiated HCCs on whole tissue sections, of which 37 had surrounding regenerative nodules while the remaining 17 had a non-cirrhotic background. CLU immunostaining was also performed on tissue microarray sections that contained 74 HCCs (40 of which were also stained for pCEA and CD10), 55 normal liver tissue samples, and 1305 non-hepatocellular tumors from multiple organs.Results Enhanced CLU canalicular staining was observed in 70% (89/128) HCCs but not in regenerative nodules, normal liver tissues or any non-hepatocellular tumors. The sensitivity and specificity for enhanced canalicular staining pattern of CLU in HCCs were 0.70 and 1.00. This enhanced canalicular pattern was observed in only 26% and 23% HCCs for CD10 and pCEA, respectively. These results further demonstrate that the distinctive enhanced canalicular pattern of CLU is unique to HCC.Conclusions CLU is superior to pCEA and CD10 as a diagnostic immunomarker in that it can help distinguish HCC not only from non-HCC malignancies but also from benign hepatocellular mass lesions.

The diagnostic value of the assay of des-γ-carboxy prothrombin in the detection of small hepatocellular carcinoma

1991 ◽  
Vol 13 (1) ◽  
pp. 21-24 ◽  
Author(s):  
Cho-Yu Chan ◽  
Shou-Dong Lee ◽  
Jaw-Ching Wu ◽  
Han-Chieh Lin ◽  
Yi-Shin Huang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Diagnostic Value ◽  
Small Hepatocellular Carcinoma
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