Oral supplementation with branched-chain amino acid granules prevents hepatocarcinogenesis in patients with hepatitis C-related cirrhosis: A propensity score analysis

2013 ◽  
Vol 44 (3) ◽  
pp. 288-295 ◽  
Author(s):  
Toshifumi Tada ◽  
Takashi Kumada ◽  
Hidenori Toyoda ◽  
Seiki Kiriyama ◽  
Makoto Tanikawa ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Amino Acid ◽  
Propensity Score ◽  
Propensity Score Analysis ◽  
Oral Supplementation ◽  
Branched Chain Amino Acid ◽  
Score Analysis ◽  
Branched Chain

scholarly journals Levocarnitine Supplementation Suppresses Lenvatinib-Related Sarcopenia in Hepatocellular Carcinoma Patients: Results of a Propensity Score Analysis

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4428
Author(s):  
Hironao Okubo ◽  
Hitoshi Ando ◽  
Eisuke Nakadera ◽  
Kenichi Ikejima ◽  
Shuichiro Shiina ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Propensity Score ◽  
Propensity Score Analysis ◽  
Inhibitory Effect ◽  
Free Carnitine ◽  
Skeletal Muscle Index ◽  
Branched Chain Amino Acid ◽  
Score Analysis ◽  
Branched Chain ◽  
Acid Administration

This study investigated the inhibitory effect of levocarnitine supplementation on sarcopenia progression in hepatocellular carcinoma (HCC) patients treated with lenvatinib. We evaluated the skeletal muscle index (SMI). After propensity score matching for age, sex, modified albumin-bilirubin grade, baseline presence of sarcopenia, and branched-chain amino acid administration, we selected 17 patients who received levocarnitine supplementation after starting lenvatinib therapy and 17 propensity-score-matched patients who did not receive levocarnitine. Sarcopenia was present in 76% of the patients at baseline. Changes in baseline SMI at 6 and 12 weeks of treatment were significantly suppressed in the group with levocarnitine supplementation compared with those without (p = 0.009 and p = 0.018, respectively). While there were no significant differences in serum free carnitine levels in cases without levocarnitine supplementation between baseline and after 6 weeks of treatment (p = 0.193), free carnitine levels were significantly higher after 6 weeks of treatment compared with baseline in cases with levocarnitine supplementation (p < 0.001). Baseline SMI and changes in baseline SMI after 6 weeks of treatment were significantly correlated with free carnitine levels (r = 0.359, p = 0.037; and r = 0.345, p = 0.045, respectively). Levocarnitine supplementation can suppress sarcopenia progression during lenvatinib therapy.

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