scholarly journals Utility of controlled attenuation parameter measurement for assessing liver steatosis in Japanese patients with chronic liver diseases

2013 ◽  
Vol 43 (11) ◽  
pp. 1182-1189 ◽  
Author(s):  
Keiichi Masaki ◽  
Shintaro Takaki ◽  
Hideyuki Hyogo ◽  
Tomoki Kobayashi ◽  
Takayuki Fukuhara ◽  
...  
Keyword(s):  
Liver Diseases ◽  
Liver Steatosis ◽  
Japanese Patients ◽  
Chronic Liver ◽  
Parameter Measurement ◽  
Chronic Liver Diseases ◽  
Controlled Attenuation Parameter ◽  
Attenuation Parameter

Potential impact of screening for fatty liver disease by transient elastography with liver stiffness and controlled attenuation parameter measurements: a pilot study

2017 ◽  
Vol 55 (08) ◽  
pp. 754-760
Author(s):  
Moritz Peiseler ◽  
Anna Creutzfeldt ◽  
Insa Cassens ◽  
Claudia Glaubke ◽  
Claudia Kroll ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Pilot Study ◽  
Liver Diseases ◽  
Transient Elastography ◽  
Liver Stiffness ◽  
Chronic Liver ◽  
Chronic Liver Diseases ◽  
Normal Range ◽  
Controlled Attenuation Parameter ◽  
Attenuation Parameter

Abstract Background The prevalence of chronic liver diseases is high in developed countries, and the leading causes are amenable to prevention. The German Lebertag is to increase awareness of the burden of chronic liver diseases in the general public. We performed a pilot study using transient elastography with liver stiffness measurement (LSM) and the controlled attenuation parameter (CAP) as a screening tool for previously unrecognized liver diseases. Patients and methods LSM and CAP was performed in 60 individuals, and participants filled in a questionnaire reporting basic characteristics and past medical history. Results Median LSM and CAP values were within the normal range. Participants with self-reported diabetes mellitus had significantly elevated LSM (p = 0.02) and CAP values (p = 0.002). Participants with a BMI > 30 kg/m2 or dyslipidemia had significantly elevated CAP values (p = 0.007 and p = 0.01, respectively) with normal LSM values. Overall, 35 % of participants had elevated CAP values, indicating a high prevalence of hepatic steatosis. Discussion In a German pilot study, diabetes mellitus was a key risk factor for increased LSM and CAP values. Prevalence of steatosis was high and comparable to other Western countries. Transient elastography is a valuable tool to identify patients with increased risk for metabolic liver diseases. In people without risk factors, LSM and CAP values were within the normal range, indicating that screening for chronic liver injury was not warranted.

Epidemiology of genotypes of hepatitis C virus in Japanese patients with type C chronic liver diseases: A multi-institution analysis

1995 ◽  
Vol 10 (5) ◽  
pp. 538-545 ◽  
Author(s):  
EIJI TANAKA ◽  
KENDO KIYOSAWA ◽  
TAKASHI MATSUSHIMA ◽  
KAZUYOSHI ISHIKAWA ◽  
KUNIHIKO HINO ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Liver Diseases ◽  
Japanese Patients ◽  
Chronic Liver ◽  
Chronic Liver Diseases ◽  
Type C

scholarly journals Liquid Biopsy for the Diagnosis of Viral Hepatitis, Fatty Liver Steatosis, and Alcoholic Liver Diseases

2020 ◽  
Vol 21 (10) ◽  
pp. 3732
Author(s):  
Ciniso Sylvester Shabangu ◽  
Jee-Fu Huang ◽  
Hui-Hua Hsiao ◽  
Ming-Lung Yu ◽  
Wan-Long Chuang ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Viral Hepatitis ◽  
Liquid Biopsy ◽  
Liver Diseases ◽  
Liver Steatosis ◽  
Chronic Liver ◽  
Chronic Liver Diseases ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Liver Diseases

During the progression from hepatitis to fibrosis, cirrhosis, and liver failure, the accumulation of stressed/damaged hepatocyte elements associated with liver inflammation is critical. The causes of hepatocyte injuries include viral hepatitis infections, alcoholic hepatitis, and non-alcoholic fatty liver disease. Hepatocyte-derived extracellular vesicles (Hep-EVs) released from stressed/damaged hepatocytes are partly responsible for liver disease progression and liver damage because they activate non-parenchymal cells and infiltrate inflammatory cells within the liver, which are in turn are an important source of EVs. This cell-to-cell signaling is prevalent during inflammation in many liver diseases. Accordingly, special emphasis should be placed on liquid biopsy methods for the long-term monitoring of chronic liver diseases. In the present review, we have highlighted various aspects of current liquid biopsy research into chronic liver diseases. We have also reviewed recent progress on liquid biopsies that focus on cell-free DNA (cfDNA), long non-coding RNA (lncRNA), and the proteins in EVs as potential diagnostic tools and novel therapeutic targets in patients with viral hepatitis, fatty liver steatosis, and alcoholic liver diseases.

Diagnostic Accuracy of Controlled Attenuation Parameter Measured by Transient Elastography for the Non-invasive Assessment of Liver Steatosis: a Prospective Study

2015 ◽  
Vol 24 (1) ◽  
pp. 35-42 ◽  
Author(s):  
Monica Lupșor-Platon ◽  
Diana Feier ◽  
Horia Stefănescu ◽  
Attila Tamas ◽  
Emil Botan ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Multivariate Regression ◽  
Transient Elastography ◽  
Liver Steatosis ◽  
Chronic Liver Diseases ◽  
Controlled Attenuation Parameter ◽  
Non Invasive ◽  
Attenuation Parameter ◽  
Ultrasound Attenuation ◽  
A Prospective Study

Background & Aims: A novel non-invasive tool based on the evaluation of ultrasound attenuation using transient elastography (TE) has been developed, called controlled attenuation parameter (CAP). We aim to establish the histopathological parameters that significantly influence CAP, the cutoff values and their performance in predicting each steatosis grade on a group of biopsied patients with chronic liver diseases (CLD) from Romania.Methods. We prospectively analyzed 201 consecutive CLD patients who underwent CAP measurements using TE. Steatosis, liver fibrosis and necroinflammatory activity were staged and graded during the pathological analysis of bioptic specimens. Univariate and multivariate regression analyses were applied to identify the variables correlated with CAP values. The diagnostic performance of CAP for steatosis prediction was assessed using an AUC analysis.Results. Among the histopathological factors correlating with CAP, the multivariate analysis found steatosis as the only factor independently influencing CAP values (p<0.001). Maximal diagnostic accuracy (DA) was obtained for the prediction of ≥34-66% (S2) fatty load and of 67-100% (S3) fatty load (82.06%, respectively 81.59%) while, for the prediction of ≥11-33% (S1) fatty load, DA reached only 76.11%. The negative predictive value for the exclusion of ≥S2 and S3 was 93.5% and 98.7%, respectively. AUCs calculated between each two steatosis grades were: 0.772 (S0 vs S1), 0.874 (S0 vs S2), 0.904 (S0 vs S3), 0.659 (S1vs S2), 0.777 (S1 vs S3), and 0.665 (S2 vs S3).Conclusion. Steatosis is the only histopathological factor independently influencing CAP. Maximal DA could be obtained for the prediction of ≥S2 and S3 (82.06% and 81.59%), while for the prediction of S1, the accuracy reached only 76.11%.

Sign in / Sign up

Export Citation Format

Share Document