Hepatic interferon-gamma-induced protein-10 expression is more strongly associated with liver fibrosis than interleukin-28B single nucleotide polymorphisms in hepatocellular carcinoma resected patients with chronic hepatitis C

2013 ◽  
Vol 43 (11) ◽  
pp. 1139-1147 ◽  
Author(s):  
Hideyuki Konishi ◽  
Ken Shirabe ◽  
Shohei Yoshiya ◽  
Tetsuo Ikeda ◽  
Toru Ikegami ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Single Nucleotide Polymorphisms ◽  
Chronic Hepatitis C ◽  
Interferon Gamma ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Interleukin 28B

Genetic risk factors for hepatocellular carcinoma associated with hepatitis C in Yakut males

2020 ◽  
pp. 14-19
Author(s):  
S.I. Malov ◽  
◽  
S.S. Sleptsova ◽  
L.A. Stepanenko ◽  
O.B. Ogarkov ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cirrhosis ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Single Nucleotide Polymorphisms ◽  
X Chromosome ◽  
Recessive Trait ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Chronic Hcv

Objective. To analyze associations between single-nucleotide polymorphisms (SNPs) in some genes located on the X chromosome and risks for hepatocellular carcinoma (HCC) in Yakut males with chronic hepatitis C infection (HCV). Patients and methods. We examined 140 Yakut males with chronic HCV in the stage of liver cirrhosis formation. In 41 of them, chronic hepatitis was complicated by HCC. All patients were tested for SNPs in the genes located on the X chromosome, including TLR7 (rs179008); TLR7 (rs179009); TLR8 (rs3764879); TLR8 (rs3764880); IRAK1 (rs3027898); MECP2 (rs1734791); TAB3 (rs1000129516); ELK1 (rs1000619237); GPC3 (rs2267531). Results. We found no significant differences in the frequencies of specific alleles of genes involved in TLR7 signaling between patients with chronic HCV and patients with HCC. However, there were significant differences in the distribution of variable sites in the rs2267531 locus of the GPC3 gene. The GPC3 gene encodes glypican-3 known as a regulator of cell proliferation and a highly specific HCC tumor marker. GPC3 mutations are inherited as an X-linked recessive trait and only males manifest this condition. The number of C-allele carriers among HCC patients was 1.5 higher than that among HCV patients without HCC. We found that chronic HCV patients carrying the C-allele are 2.7 times more likely to develop HCC than G-allele carriers (p = 0.0095). Conclusion. We found a SNP in the GPC3 gene, which C-allele was associated with an increased risk of HCC in Yakut males with chronic HCV. This genetic marker can be used for personalized prognosis of the disease course and as a predictor of HCC development in patients with liver cirrhosis. Key words: hepatitis C, hepatocellular carcinoma, glypican-3, single-nucleotide polymorphisms, Toll-like receptors, X chromosome, Yakuts

Single nucleotide polymorphisms near IL28B gene and response to treatment of chronic hepatitis C in hemodialysis patients

Renal Failure ◽  
2015 ◽  
Vol 37 (7) ◽  
pp. 1180-1184
Author(s):  
Pavlina Dzekova-Vidimliski ◽  
Igor G. Nikolov ◽  
Nadica Matevska-Geshkovska ◽  
Sami Mena ◽  
Lionel Rostaing ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Single Nucleotide Polymorphisms ◽  
Chronic Hepatitis C ◽  
Hemodialysis Patients ◽  
Response To Treatment ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

scholarly journals Impact of IL28B-Related Single Nucleotide Polymorphisms on Liver Histopathology in Chronic Hepatitis C Genotype 2 and 3

PLoS ONE ◽  
2012 ◽  
Vol 7 (1) ◽  
pp. e29370 ◽  
Author(s):  
Karolina Rembeck ◽  
Åsa Alsiö ◽  
Peer Brehm Christensen ◽  
Martti Färkkilä ◽  
Nina Langeland ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Single Nucleotide Polymorphisms ◽  
Chronic Hepatitis C ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Liver Histopathology ◽  
Genotype 2

Study of CXCL9-11 gene polymorphisms in liver fibrosis among patients with chronic hepatitis C

2021 ◽  
Author(s):  
Mariana Cavalheiro Magri ◽  
Maria Stella Montanha Alvarez ◽  
Anny Ayumi Iogi ◽  
Grayce Mendes Alves ◽  
Caroline Manchiero ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Genetic Model ◽  
High Linkage Disequilibrium ◽  
Nucleotide Polymorphisms ◽  
Advanced Fibrosis ◽  
Single Nucleotide ◽  
Pathogenic Factors

Abstract Several factors are associated with the progression of chronic hepatitis C: comorbidities, lifestyle, and pathogenic factors, including immune response, apoptosis and heredity. Single nucleotide polymorphisms (SNPs) in the PNPLA3 and TM6SF2 genes are more widely studied genetic risk factors, while CXCL9–11 chemokines produced by hepatocytes in the process of infection are less well studied. Our aim was to evaluate the influence of CXCL9 rs10336, CXCL10 rs3921 and CXCL11 rs4619915 in liver fibrosis when analysed together with PNPLA3 rs738409 and TM6SF2 rs58542926. The study included 219 patients with chronic hepatitis C. SNP genotyping was performed by real-time PCR. Univariate and multivariate analyses were used to detect the association between SNPs and advanced fibrosis in a recessive genetic model. All SNPs had a minimum allele frequency > 5%, and CXCL9 rs10336, CXCL10 rs3921 and CXCL11 rs4619915 were in high linkage disequilibrium (D’ ≥0.84). In the multivariate analysis, we observed that male gender (p = 0.000), older age (p = 0.025), moderate to intense inflammatory activity (p = 0.002), moderate to accentuated hepatic steatosis (p = 0.026) and the CT genotype of the TM6SF2 rs58542926 SNP (p = 0.014) presented significant associations with advanced fibrosis. Overall, the CXCL9 rs10336, CXCL10 rs3921, CXCL11 rs4619915 and PNPLA3 rs738409 SNPs did not influence liver fibrosis among patients with chronic hepatitis C.

scholarly journals Response Prediction in Chronic Hepatitis C by Assessment of IP-10 and IL28B-Related Single Nucleotide Polymorphisms

PLoS ONE ◽  
2011 ◽  
Vol 6 (2) ◽  
pp. e17232 ◽  
Author(s):  
Martin Lagging ◽  
Galia Askarieh ◽  
Francesco Negro ◽  
Stephanie Bibert ◽  
Jonas Söderholm ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Single Nucleotide Polymorphisms ◽  
Chronic Hepatitis C ◽  
Response Prediction ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide
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