Heat‐killed Helicobacter pylori upregulates NKG2D ligands expression on gastric adenocarcinoma cells via Toll‐like receptor 4

Helicobacter ◽  
2021 ◽  
Author(s):  
Carolina Hernández ◽  
Karen Toledo‐Stuardo ◽  
Paulina García‐González ◽  
Macarena Garrido‐Tapia ◽  
Karina Kramm ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Adenocarcinoma ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Nkg2d Ligands ◽  
Adenocarcinoma Cells

scholarly journals Association of toll-like receptor 4, 5 and 10 polymorphisms with Helicobacter pylori -positive peptic ulcer disease in a center in Jordan

2021 ◽  
Vol 41 (4) ◽  
pp. 206-215
Author(s):  
Laith AL-Eitan ◽  
Fouad Abdelaziz Almomani ◽  
Sohaib Mahmoud Al-Khatib ◽  
Hanan Abdulraheem Aljamal ◽  
Mohammed Nayef Al-Qusami ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Conflicts Of Interest ◽  
Care Center ◽  
Treatment Success ◽  
Tertiary Care ◽  
Genotype Distribution ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
H Pylori

BACKGROUND: Helicobacter pylori infection is widespread, affecting about 50% of the global population. Polymorphisms in host genes such as the toll-like receptor 4 ( TLR4 ) might affect the susceptibility and severity of infection and treatment success. OBJECTIVE: Investigate the susceptibility and severity of H pylori infection with host TLR4 (rs11536889, rs4986790, rs200109652, rs10759932), TLR5 (rs5744174, rs2072493, rs746250566), TLR10 (rs559182335, rs10004195) polymorphisms. DESIGN: Analytical, cross-sectional. SETTING: Endoscopy clinic at tertiary care center. PATIENTS AND METHODS: Genomic DNA was extracted from formalin-fixed paraffin-embedded tissues collected from H pylori -infected patients and healthy individuals. The single nucleotide polymorphisms (SNPs) within the targeted TLR genes were genotyped to assess the genetic association of various SNPs with disease severity. MAIN OUTCOME MEASURES: Effect of genotype distribution on H pylori infection. SAMPLE SIZE: 250 peptic ulcer patients and 217 controls. RESULTS: The TLR10 genotype showed no significant association with H pylori infection except for rs10004195 (T>A) ( P =.002). The genotype frequency of Rs5744174 in TLR5 had a significant association with the presence of H pylori infection ( P =.046, OR=0.52). Except for gender (P=.022), there were no significant associations between clinical and demographic variables and SNPs relating to the severity of the H pylori infections. CONCLUSIONS: Our findings are consistent with differences in severity of H pylori infection due to TLR SNPs in different ethnic groups. Understanding differences in genetic susceptibility could help in classifying patients and matching patients with various treatment options on a genetic basis. LIMITATIONS: Lack of H pylori pathogenicity features assessment. CONFLICTS OF INTEREST: None.

scholarly journals Inhibitory effect of piperine on Helicobacter pylori growth and adhesion to gastric adenocarcinoma cells

2014 ◽  
Vol 9 (1) ◽  
pp. 43 ◽  
Author(s):  
Nagendran Tharmalingam ◽  
Sa-Hyun Kim ◽  
Min Park ◽  
Hyun Woo ◽  
Hyun Kim ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Adenocarcinoma ◽  
Inhibitory Effect ◽  
Adenocarcinoma Cells

Statins Inhibit Toll-Like Receptor 4–Mediated Growth of Human Esophageal Adenocarcinoma Cells

2020 ◽  
Author(s):  
Anna K. Gergen ◽  
Patrick D. Kohtz ◽  
Alison L. Halpern ◽  
Allana M. White ◽  
Xianzhong Meng ◽  
...  
Keyword(s):  
Esophageal Adenocarcinoma ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Adenocarcinoma Cells
Sign in / Sign up

Export Citation Format

Share Document