Long‐term changes in the gut microbiota after 14‐day bismuth quadruple therapy in penicillin‐allergic children

Helicobacter ◽  
2020 ◽  
Vol 25 (5) ◽  
Author(s):  
Ying Zhou ◽  
Ziqing Ye ◽  
Junping Lu ◽  
Shijian Miao ◽  
Xiaolan Lu ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Quadruple Therapy ◽  
Long Term Changes

scholarly journals Postoperative Complications Are Associated with Long-Term Changes in the Gut Microbiota Following Colorectal Cancer Surgery

Life ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 246
Author(s):  
Felix C.F. Schmitt ◽  
Martin Schneider ◽  
William Mathejczyk ◽  
Markus A. Weigand ◽  
Jane C. Figueiredo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Postoperative Complications ◽  
Gut Microbiota ◽  
Gut Microbiome ◽  
Tumor Resection ◽  
Microbial Composition ◽  
Colorectal Cancer Surgery ◽  
Long Term Changes ◽  
Stool Samples

Changes in the gut microbiome have already been associated with postoperative complications in major abdominal surgery. However, it is still unclear whether these changes are transient or a long-lasting effect. Therefore, the aim of this prospective clinical pilot study was to examine long-term changes in the gut microbiota and to correlate these changes with the clinical course of the patient. Methods: In total, stool samples of 62 newly diagnosed colorectal cancer patients undergoing primary tumor resection were analyzed by 16S-rDNA next-generation sequencing. Stool samples were collected preoperatively in order to determine the gut microbiome at baseline as well as at 6, 12, and 24 months thereafter to observe longitudinal changes. Postoperatively, the study patients were separated into two groups—patients who suffered from postoperative complications (n = 30) and those without complication (n = 32). Patients with postoperative complications showed a significantly stronger reduction in the alpha diversity starting 6 months after operation, which does not resolve, even after 24 months. The structure of the microbiome was also significantly altered from baseline at six-month follow-up in patients with complications (p = 0.006). This was associated with a long-lasting decrease of a large number of species in the gut microbiota indicating an impact in the commensal microbiota and a long-lasting increase of Fusobacterium ulcerans. The microbial composition of the gut microbiome shows significant changes in patients with postoperative complications up to 24 months after surgery.

scholarly journals Low-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Sophie Leclercq ◽  
Firoz M. Mian ◽  
Andrew M. Stanisz ◽  
Laure B. Bindels ◽  
Emmanuel Cambier ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Early Life ◽  
Low Dose ◽  
Long Term Changes ◽  
And Behavior

scholarly journals Long-term impact of fecal transplantation in healthy volunteers

2019 ◽  
Author(s):  
Oleg V Goloshchapov ◽  
Evgenii I Olekhnovich ◽  
Sergey V Sidorenko ◽  
Ivan S Moiseev ◽  
Maxim A Kucher ◽  
...  
Keyword(s):  
Adverse Events ◽  
Gut Microbiota ◽  
Healthy Volunteers ◽  
Fecal Microbiota Transplantation ◽  
Rrna Gene ◽  
Clinical Effects ◽  
Microbiota Composition ◽  
Gut Colonization ◽  
Long Term Changes

AbstractBackgroundFecal microbiota transplantation (FMT) is now approved for the treatment of refractory recurrent clostridial colitis, but a number of studies are ongoing in inflammatory bowel diseases, i.e., Crohn’s disease, nonspecific ulcerative colitis, and in other autoimmune conditions. In most cases, the effects of FMT are evaluated on patients with initially altered microbiota. The aim of the present study was to evaluate effects of FMT on the gut microbiota composition in healthy volunteers and to track long-term changes.ResultsWe have performed a combined analysis of three healthy volunteers before and after FMT with frozen capsules, followed by evaluation of their general condition, adverse clinical effects, changes of basic laboratory parameters, and several immune markers. Intestinal microbiota samples were evaluated by 16S rRNA gene sequencing (16S seq) and shotgun sequencing (or whole-genome sequencing – WGS). The data analysis demonstrated the profound shift towards the donor microbiota taxonomic composition in all volunteers. Following FMT, all the volunteers exhibited gut colonization with donor gut bacteria, and persistence of this effect for almost ~1 year of observation. Transient changes of immune parameters were consistent with suppression of T-cell cytotoxicity. FMT was well tolerated with mild gastrointestinal adverse events and systemic inflammatory response in one volunteer.ConclusionsThe FMT procedure leads to significant long-term changes of the gut microbiota in healthy volunteers with the shift towards donor microbiota composition, being relatively safe to the recipients without long-term adverse events.

scholarly journals Long-Term Iron Deficiency and Dietary Iron Excess Exacerbate Acute Dextran Sodium Sulphate-Induced Colitis and Are Associated with Significant Dysbiosis

2021 ◽  
Vol 22 (7) ◽  
pp. 3646
Author(s):  
Awad Mahalhal ◽  
Michael D. Burkitt ◽  
Carrie A. Duckworth ◽  
Georgina L. Hold ◽  
Barry J. Campbell ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Iron Supplementation ◽  
Sodium Sulphate ◽  
Dietary Iron ◽  
Chronic Colitis ◽  
Dextran Sodium Sulphate ◽  
Acute Colitis ◽  
Long Term Changes ◽  
The Impact

Background: Oral iron supplementation causes gastrointestinal side effects. Short-term alterations in dietary iron exacerbate inflammation and alter the gut microbiota, in murine models of colitis. Patients typically take supplements for months. We investigated the impact of long-term changes in dietary iron on colitis and the microbiome in mice. Methods: We fed mice chow containing differing levels of iron, reflecting deficient (100 ppm), normal (200 ppm), and supplemented (400 ppm) intake for up to 9 weeks, both in absence and presence of dextran sodium sulphate (DSS)-induced chronic colitis. We also induced acute colitis in mice taking these diets for 8 weeks. Impact was assessed (i) clinically and histologically, and (ii) by sequencing the V4 region of 16S rRNA. Results: In mice with long-term changes, the iron-deficient diet was associated with greater weight loss and histological inflammation in the acute colitis model. Chronic colitis was not influenced by altering dietary iron however there was a change in the microbiome in DSS-treated mice consuming 100 ppm and 400 ppm iron diets, and control mice consuming the 400 ppm iron diet. Proteobacteria levels increased significantly, and Bacteroidetes levels decreased, in the 400 ppm iron DSS group at day-63 compared to baseline. Conclusions: Long-term dietary iron alterations affect gut microbiota signatures but do not exacerbate chronic colitis, however acute colitis is exacerbated by such dietary changes. More work is needed to understand the impact of iron supplementation on IBD. The change in the microbiome, in patients with colitis, may arise from the increased luminal iron and not simply from colitis.

P.0498 Social isolation in adolescence and long-term changes in the gut microbiota composition

2021 ◽  
Vol 53 ◽  
pp. S367-S368
Author(s):  
N. Lopizzo ◽  
M. Marizzoni ◽  
M. Mazzelli ◽  
V. Begni ◽  
L.M. Borruso ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Social Isolation ◽  
Microbiota Composition ◽  
Long Term Changes ◽  
Gut Microbiota Composition
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