An updated systematic review and meta-analysis on the association betweenHelicobacter pyloriinfection and iron deficiency anemia

Helicobacter ◽  
2016 ◽  
Vol 22 (1) ◽  
pp. e12330 ◽  
Author(s):  
Lauren Hudak ◽  
Ameen Jaraisy ◽  
Saeda Haj ◽  
Khitam Muhsen
2018 ◽  
Vol 36 (04) ◽  
pp. 366-376 ◽  
Author(s):  
Richard Burwick ◽  
Shravya Govindappagari

Objective To perform a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess the benefits of intravenous (IV) iron in pregnancy. Study Design Systematic review was registered with PROSPERO and performed using PRISMA guidelines. PubMed, MEDLINE, Web of Science, ClinicalTrials.gov, Cochrane Library, and Google Scholar were searched. Eleven RCTs, comparing IV to oral iron for treatment of iron-deficiency anemia in pregnancy, were included. Meta-analyses were performed with Stata software (College Station, TX), utilizing random effects model and method of DerSimonian and Laird. Outcomes were assessed by pooled odds ratios (OR) or pooled weighted mean difference (WMD). Sensitivity analyses were performed for heterogeneity. Results We found that pregnant women receiving IV iron, compared with oral iron, had the following benefits: (1) Achieved target hemoglobin more often, pooled OR 2.66 (95% confidence interval [CI]: 1.71–4.15), p < 0.001; (2) Increased hemoglobin level after 4 weeks, pooled WMD 0.84 g/dL (95% CI: 0.59–1.09), p < 0.001; (3) Decreased adverse reactions, pooled OR 0.35 (95% CI: 0.18–0.67), p = 0.001. Results were unchanged following sensitivity analyses. Conclusion In this meta-analysis, IV iron is superior to oral iron for treatment of iron-deficiency anemia in pregnancy. Women receiving IV iron more often achieve desired hemoglobin targets, faster and with fewer side effects.


Hematology ◽  
2016 ◽  
Vol 22 (4) ◽  
pp. 231-239 ◽  
Author(s):  
Maryam Akbari ◽  
Mahmood Moosazadeh ◽  
Reza Tabrizi ◽  
Seyed Reza Khatibi ◽  
Mahmoud Khodadost ◽  
...  

2018 ◽  
Vol 9 (3) ◽  
pp. 207-218 ◽  
Author(s):  
María J Ramírez-Luzuriaga ◽  
Leila M Larson ◽  
Venkatesh Mannar ◽  
Reynaldo Martorell

2018 ◽  
Vol 155 (2) ◽  
pp. 374-382.e1 ◽  
Author(s):  
Srihari Mahadev ◽  
Monika Laszkowska ◽  
Johan Sundström ◽  
Magnus Björkholm ◽  
Benjamin Lebwohl ◽  
...  

2019 ◽  
Vol 39 (4) ◽  
pp. 519-532 ◽  
Author(s):  
Adam K. Lewkowitz ◽  
Anjlie Gupta ◽  
Laura Simon ◽  
Bethany A. Sabol ◽  
Carrie Stoll ◽  
...  

2019 ◽  
Vol Volume 10 ◽  
pp. 111-117 ◽  
Author(s):  
Mahboubeh Nazari ◽  
Esmaeil Mohammadnejad ◽  
Sahar Dalvand ◽  
Reza Ghanei Gheshlagh

2021 ◽  
Vol 8 ◽  
Author(s):  
Seetha Anitha ◽  
Joanna Kane-Potaka ◽  
Rosemary Botha ◽  
D. Ian Givens ◽  
Nur Liana Binti Sulaiman ◽  
...  

The prevalence of iron deficiency anemia is highest among low and middle-income countries. Millets, including sorghum, are a traditional staple in many of these countries and are known to be rich in iron. However, a wide variation in the iron composition of millets has been reported, which needs to be understood in consonance with its bioavailability and roles in reducing anemia. This systematic review and meta-analysis were carried out to analyze the scientific evidence on the bioavailability of iron in different types of millets, processing, and the impact of millet-based food on iron status and anemia. The results indicated that iron levels in the millets used to study iron bioavailability (both in vivo and in vitro) and efficacy varied with the type and variety from 2 mg/100 g to 8 mg/100 g. However, not all the efficacy studies indicated the iron levels in the millets. There were 30 research studies, including 22 human interventions and 8 in vitro studies, included in the meta-analysis which all discussed various outcomes such as hemoglobin level, serum ferritin level, and absorbed iron. The studies included finger millet, pearl millet, teff and sorghum, or a mixture of millets. The results of 19 studies conducted on anaemic individuals showed that there was a significant (p &lt; 0.01) increase in hemoglobin levels by 13.2% following regular consumption (21 days to 4.5 years) of millets either as a meal or drink compared with regular diets where there was only 2.7% increase. Seven studies on adolescents showed increases in hemoglobin levels from 10.8 ± 1.4 (moderate anemia) to 12.2 ± 1.5 g/dl (normal). Two studies conducted on humans demonstrated that consumption of a pearl millet-based meal significantly increased the bioavailable iron (p &lt; 0.01), with the percentage of bioavailability being 7.5 ± 1.6, and provided bioavailable iron of 1 ± 0.4 mg. Four studies conducted on humans showed significant increases in ferritin level (p &lt; 0.05) up to 54.7%. Eight in-vitro studies showed that traditional processing methods such as fermentation and germination can improve bioavailable iron significantly (p &lt; 0.01) by 3.4 and 2.2 times and contributed to 143 and 95% of the physiological requirement of women, respectively. Overall, this study showed that millets can reduce iron deficiency anemia.


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