A multicenter study of the clinical, laboratory characteristics, and potential prognostic factors in patients with amyloid A amyloidosis on hemodialysis

2021 ◽  
Author(s):  
Ece Bilgic Koylu ◽  
Rezzan Eren Sadioglu ◽  
Sahin Eyupoglu ◽  
Ihsan Ergun ◽  
Gokhan Nergizoglu ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Multicenter Study ◽  
Clinical Laboratory ◽  
Amyloid A

Clinical, laboratory features, and prognostic factors in adult acute transverse myelitis: an Italian multicenter study

2019 ◽  
Vol 40 (7) ◽  
pp. 1383-1391
Author(s):  
Pasquale Annunziata ◽  
Gianni Masi ◽  
Chiara Cioni ◽  
Matteo Gastaldi ◽  
Enrico Marchioni ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Multicenter Study ◽  
Clinical Laboratory ◽  
Transverse Myelitis ◽  
Acute Transverse Myelitis ◽  
Laboratory Features

scholarly journals Swedish National Multicenter Study on Head and Neck Cancer of Unknown Primary: Prognostic Factors and Impact of Treatment on Survival

2020 ◽  
Author(s):  
Lars Axelsson ◽  
Erik Holmberg ◽  
Jan Nyman ◽  
Anders Högmo ◽  
Helena Sjödin ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Prognostic Factors ◽  
Head And Neck ◽  
Neck Dissection ◽  
Neck Cancer ◽  
Multicenter Study ◽  
Performance Status ◽  
Cancer Of Unknown Primary ◽  
Unknown Primary ◽  
N Stage

Abstract Introduction Head and neck cancer of unknown primary (HNCUP) is a rare condition whose prognostic factors that are significant for survival vary between studies. No randomized treatment study has been performed thus far, and the optimal treatment is not established. Objective The present study aimed to explore various prognostic factors and compare the two main treatments for HNCUP: neck dissection and (chemo) radiation vs primary (chemo) radiation. Methods A national multicenter study was performed with data from the Swedish Head and Neck Cancer Register (SweHNCR) and from the patients' medical records from 2008 to 2012. Results Two-hundred and sixty HNCUP patients were included. The tumors were HPV-positive in 80%. The overall 5-year survival rate of patients treated with curative intent was 71%. Age (p < 0.001), performance status (p= 0.036), and N stage (p= 0.046) were significant factors for overall survival according to the multivariable analysis. Treatment with neck dissection and (chemo) radiation (122 patients) gave an overall 5-year survival of 73%, and treatment with primary (chemo) radiation (87 patients) gave an overall 5-year survival of 71%, with no significant difference in overall or disease-free survival between the 2 groups. Conclusions Age, performance status, and N stage were significant prognostic factors. Treatment with neck dissection and (chemo) radiation and primary (chemo) radiation gave similar survival outcomes. A randomized treatment study that includes quality of life is needed to establish the optimal treatment.

scholarly journals Evaluation of poor prognostic factors of respiratory related death in microscopic polyangiitis complicated by interstitial lung disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Shogo Matsuda ◽  
Takuya Kotani ◽  
Takayasu Suzuka ◽  
Takao Kiboshi ◽  
Keisuke Fukui ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Clinical Laboratory ◽  
Microscopic Polyangiitis ◽  
Survival Rates ◽  
Lower Lobe ◽  
Left Lower Lobe ◽  
Fibrosis Score ◽  
High Resolution Computed Tomography

AbstractThe prognosis of microscopic polyangiitis (MPA) with interstitial lung disease (ILD) is significantly worse than that of MPA without ILD. However, the clinical characteristics in MPA-ILD, especially poor prognostic factors, are not elucidated. We evaluated demographic, clinical, laboratory, and radiological findings, treatments, and outcomes of 80 patients with MPA, and investigated prognostic factors of respiratory-related death in patients with myeloperoxidase (MPO)-anti-neutrophil cytoplasmic antibody (ANCA) positive MPA-ILD. Ground-glass opacity and fibrosis were evaluated as scores on high-resolution computed tomography (HRCT). The presence of ILD was consistent with a high risk of respiratory-related death (hazard ratio, 4.8; P = 0.04). Multivariable logistic regression analyses using propensity scoring showed right or left lower lobe fibrosis score to be significantly associated with respiratory-related death (P = 0.0005 and 0.0045, respectively). A right or left lower lobe fibrosis score ≥ 2, indicating the presence of honeycombing at 1 cm above the diaphragm, was determined to be the best cut-off value indicating a poor prognosis. The 5-year survival rate was significantly lower in patients with right or left lower lobe fibrosis score ≥ 2 (survival rates: 37% and 19%, respectively) than those with a score < 2 (71% and 68%, respectively) (P = 0.002 and 0.0007, respectively). These findings suggest that the presence of honeycomb lesions in bilateral lower lobes on chest HRCT was associated with respiratory-related death in patients with MPO-ANCA positive MPA-ILD.

Treatment and Prognostic Factors in Primary Peritoneal Carcinoma: A Multicenter Study of the Anatolian Society of Medical Oncology (ASMO)

2014 ◽  
Vol 37 (6) ◽  
pp. 332-338 ◽  
Author(s):  
Olcun U. Unal ◽  
İlhan Oztop ◽  
Ozan Yazici ◽  
Tahsin Ozatli ◽  
Ali İnal ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Multicenter Study ◽  
Medical Oncology ◽  
Peritoneal Carcinoma ◽  
Primary Peritoneal Carcinoma

506 AGE AND GENDER, INDEPENDENT PROGNOSTIC FACTORS OF RENAL CELL CARCINOMAS: A MULTICENTER STUDY

2011 ◽  
Vol 10 (2) ◽  
pp. 170
Author(s):  
C.Y. Oh ◽  
C.H. Yoo ◽  
J.S. Cho ◽  
S.I. Kim ◽  
Y.S. Kim ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Multicenter Study ◽  
Renal Cell ◽  
Renal Cell Carcinomas ◽  
Age And Gender ◽  
And Gender

Prognostic Factors of Uterine Serous Carcinoma—A Multicenter Study

2018 ◽  
Vol 28 (6) ◽  
pp. 1138-1144 ◽  
Author(s):  
Xiaozhu Zhong ◽  
Jianliu Wang ◽  
Tengen Kaku ◽  
Zhiqi Wang ◽  
Xiaoping Li ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Multicenter Study ◽  
Serous Carcinoma ◽  
Uterine Serous Carcinoma

scholarly journals A multicenter study to evaluate harmonization of assays for N-terminal propeptide of type I procollagen (PINP): a report from the IFCC-IOF Joint Committee for Bone Metabolism

2019 ◽  
Vol 57 (10) ◽  
pp. 1546-1555 ◽  
Author(s):  
Etienne Cavalier ◽  
Richard Eastell ◽  
Niklas Rye Jørgensen ◽  
Konstantinos Makris ◽  
Symeon Tournis ◽  
...  
Keyword(s):  
Multicenter Study ◽  
Evaluation Method ◽  
Clinical Laboratory ◽  
Cellular Level ◽  
Type I ◽  
Type I Procollagen ◽  
Edta Plasma ◽  
Turnover Markers ◽  
Routine Clinical Laboratory ◽  
The Relationship

Abstract Background Biochemical bone turnover markers (BTM) are useful tools to assess bone remodeling at the cellular level. N-terminal propeptide of type I procollagen (PINP) has been recommended as a reference marker for bone formation in research studies. Methods We describe the results of a multicenter study for routine clinical laboratory assays for PINP in serum and plasma. Four centers (Athens, Greece [GR], Copenhagen, Denmark [DK], Liege, Belgium [BE] and Sheffield, United Kingdom [UK]) collected serum and plasma (EDTA) samples from 796 patients presenting to osteoporosis clinics. Specimens were analyzed in duplicate with each of the available routine clinical laboratory methods according to the manufacturers’ instructions. Passing-Bablok regressions, Bland-Altman plots, V-shape evaluation method and the concordance correlation coefficient for PINP values between serum and plasma specimens and between methods were used to determine the agreement between results. A generalized linear model was employed to identify possible variables that affected the relationship between the methods. Results We showed that both EDTA plasma and serum were suitable for PINP determination. We observed a significant proportional bias between Orion radioimmunoassay and the automated methods for PINP (Roche Cobas and IDS iSYS), which both gave very similar results. The multivariate model did not improve the excellent correlation that was observed between the methods. Conclusions Harmonization of PINP assays is possible by applying a correction factor or correctly assigning the values of the calibrators. This work will benefit from further collaboration between assays manufacturers and clinical laboratory professionals.

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