Correction of hyponatremia by infusing D5W (5% dextrose in water solution) prefilter in patients receiving continuous renal replacement therapy: A case series

2020 ◽  
Vol 24 (2) ◽  
Author(s):  
Cassiopia Lippold ◽  
Ami Patel
Keyword(s):  
Renal Replacement Therapy ◽  
Continuous Renal Replacement Therapy ◽  
Replacement Therapy ◽  
Water Solution ◽  
Case Series

scholarly journals Continuous Renal Replacement Therapy with the Adsorbing Filter oXiris in Septic Patients: A Case Series

2019 ◽  
Vol 47 (Suppl. 3) ◽  
pp. 54-58 ◽  
Author(s):  
Franco Turani ◽  
Riccardo Barchetta ◽  
Mauro Falco ◽  
Silvia Busatti ◽  
Luca Weltert
Keyword(s):  
Renal Replacement Therapy ◽  
Continuous Renal Replacement Therapy ◽  
Replacement Therapy ◽  
Medical Records ◽  
Time Course ◽  
Case Series ◽  
Kidney Injury ◽  
Immunological Response ◽  
Respiratory Parameters ◽  
Endotoxin Activity

Background: Extracorporeal treatment may be useful during sepsis, but definitive recommendations are lacking. Aim of this study is to review retrospectively the medical records of septic patients submitted to continuous renal replacement therapy (CRRT) with the adsorbing membrane oXiris and evaluate (1) the safety of the device, (2) the cardiorenal response, and (3) the immunological response. Materials and Methods: The medical records of 60 septic patients submitted to CRRT with the membrane oXiris from April 2011 to December 2018 have been reviewed. The adsorbing membrane oXiris® (Baxter, IL, USA) was used through a Prisma plataform (Prismaflex – Baxter, IL, USA). At basal time (T0), at 24 h (T1), and at the end of the treatment (T2) were analyzed the clinical data, the cytokines, and the time course of endotoxin. Results: Sixty patients were included in the study. In total, 85% of patients had acute kidney injury (AKI). Every CRRT treatment was of 72 ± 13 h, with the consumption of 3.2 ± 1 filters. No AE events were reported. The main cardiorenal and respiratory parameters improved with a decrease of the noradrenaline dosage. Cytokines, procalcitonin, and endotoxin activity assay decreased too. SOFA total improved from 12.4 ± 2 to 9 ± 2. Conclusion: In sepsis/septic shock patients with AKI, CRRT with the adsorbing membrane oXiris may be safe and improves the cardiorenal – function and the clinical condition. The effect on cytokines and endotoxin may explain in part these results. A RCT is warranted to confirm these data.

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