A single center, open-label, randomized, parallel group study assessing the relationship between asymptomatic bacteriuria and inflammation in maintenance hemodialysis patients

2017 ◽  
Vol 22 (1) ◽  
pp. 110-118
Author(s):  
Ilia Beberashvili ◽  
Evgeni Golovko ◽  
Liat Golinsky ◽  
Nedal Garra ◽  
Inna Sinuani ◽  
...  
Keyword(s):  
Asymptomatic Bacteriuria ◽  
Hemodialysis Patients ◽  
Maintenance Hemodialysis ◽  
Single Center ◽  
Open Label ◽  
Parallel Group Study ◽  
Parallel Group ◽  
The Relationship ◽  
Maintenance Hemodialysis Patients

Appraising Stroke Risk in Maintenance Hemodialysis Patients: A Large Single-Center Cohort Study

2012 ◽  
Vol 59 (2) ◽  
pp. 249-257 ◽  
Author(s):  
Albert Power ◽  
Kakit Chan ◽  
Seema K. Singh ◽  
David Taube ◽  
Neill Duncan
Keyword(s):  
Cohort Study ◽  
Stroke Risk ◽  
Hemodialysis Patients ◽  
Maintenance Hemodialysis ◽  
Single Center ◽  
Maintenance Hemodialysis Patients

scholarly journals β-Blocker Dialyzability in Maintenance Hemodialysis Patients

2018 ◽  
Vol 13 (4) ◽  
pp. 604-611 ◽  
Author(s):  
Alvin Tieu ◽  
Thomas J. Velenosi ◽  
Andrew S. Kucey ◽  
Matthew A. Weir ◽  
Bradley L. Urquhart
Keyword(s):  
Crossover Trial ◽  
Random Order ◽  
Hemodialysis Patients ◽  
Maintenance Hemodialysis ◽  
Open Label ◽  
Drug Concentrations ◽  
Β Blocker ◽  
Difference Methods ◽  
Available Information ◽  
Maintenance Hemodialysis Patients

Background and objectivesThere is a paucity of data available to describe drug dialyzability. Of the available information, most was obtained before implementation of modern hemodialysis membranes. Our study characterized dialyzability of the most commonly prescribed β-blockers in patients undergoing high-flux hemodialysis.Design, setting, participants, & measurementsPatients on hemodialysis (n=8) were recruited to an open label, pharmacokinetic, four-way crossover trial. Single doses of atenolol, metoprolol, bisoprolol, and carvedilol were administered on separate days in random order to each patient. Plasma and dialysate drug concentrations were measured, and dialyzability was determined by the recovery clearance and arterial venous difference methods.ResultsUsing the recovery clearance method, the dialytic clearance values for atenolol, metoprolol, bisoprolol, and carvedilol were 72, 87, 44, and 0.2 ml/min, respectively (P<0.001). Applying the arterial venous difference method, the dialytic clearance values of atenolol, metoprolol, bisoprolol, and carvedilol were 167, 114, 96, and 24 ml/min, respectively (P<0.001).ConclusionsAtenolol and metoprolol are extensively cleared by hemodialysis compared with the negligible dialytic clearance of carvedilol. Contrary to estimates of dialyzability on the basis of previous literature, our data indicate that bisoprolol is also dialyzable. This finding highlights the importance of conducting dialyzability studies to definitively characterize drug dialytic clearance.

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