Facial disfigurement due to osteitis fibrosa cystica or brown tumor from secondary hyperparathyroidism in patients on dialysis: A systematic review and an illustrative case report

2015 ◽  
Vol 19 (4) ◽  
pp. 583-592 ◽  
Author(s):  
Rafael M. Baracaldo ◽  
Dashi Bao ◽  
Pichet Iampornpipopchai ◽  
Joshua Fogel ◽  
Sofia Rubinstein
Keyword(s):  
Systematic Review ◽  
Case Report ◽  
Secondary Hyperparathyroidism ◽  
Osteitis Fibrosa ◽  
Illustrative Case ◽  
Brown Tumor ◽  
Osteitis Fibrosa Cystica ◽  
Facial Disfigurement

Giant parathyroid adenoma diagnosed by brown tumor, a clinical manifestation of primary hyperparathyroidism: a case report

2021 ◽  
pp. 1-8
Author(s):  
Banu Yigit ◽  
Mert Tanal ◽  
Bulent Citgez
Keyword(s):  
Case Report ◽  
Primary Hyperparathyroidism ◽  
Secondary Hyperparathyroidism ◽  
Parathyroid Adenoma ◽  
Benign Lesion ◽  
Brown Tumor ◽  
Skeletal System ◽  
Radiological Findings ◽  
Facial Bones ◽  
Osteitis Fibrosa Cystica

Abstract Brown tumor (BT) is the pathological expression of osteitis fibrosa cystica owing to primary and secondary hyperparathyroidism (HPT). It is a rare benign lesion of skeletal system that usually affects the facial bones, clavicles, ribs, pelvis and extremities. The purpose of this case report is to present the clinical, pathological and radiological findings of BT, rarely seen in adults, originating from the giant parathyroid adenoma and emerging as the first clinical sign of HPT. The patient underwent a successful parathyroidectomy operation and on the first postoperative day, the patient was discharged without any complications. Continuous...

scholarly journals Maxillary Brown Tumor as a Rare Complication of Hyperparathyroidism

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A205-A206
Author(s):  
Janet Colón Castellano ◽  
Nydia Ivette Burgos Ortega ◽  
Nicole Hernandez Cordero ◽  
Walter Morales Borrero ◽  
Yadiel Rivera Nieves ◽  
...  
Keyword(s):  
Secondary Hyperparathyroidism ◽  
Serum Calcium ◽  
Early Recognition ◽  
Rare Complication ◽  
Osteitis Fibrosa ◽  
Brown Tumor ◽  
Histologic Diagnosis ◽  
Osteitis Fibrosa Cystica ◽  
Brown Tumors ◽  
Nasal Bleeding

Abstract Secondary hyperparathyroidism is a common complication of end stage renal disease (ESRD). The inherent impaired phosphorus and calcium metabolism result in altered bone metabolism, which rarely may manifest as osteitis fibrosa cystica with approximately 2% presenting as brown tumors. Brown tumors are areas of excessive bone resorption replaced by giant cells and fibrovascular tissue. Maxillofacial brown tumors are rare and result in increased patient morbidity due to associated nasal bleeding, diffuse pain and focal deformities. Nonetheless, these tumors are treatable and may regress following reduced parathyroid hormone (PTH) levels. Case of a 64-years-old Hispanic male with history of ESRD on hemodialysis for more than 20 years, secondary hyperparathyroidism with fragility fractures of femur status post parathyroidectomy on years 1999 and 2010, coronary artery disease and hypertension, who was consulted to our service for evaluation of a bleeding nasal septum mass suspected of a brown tumor. The patient presented to the emergency room with a massive spontaneous nasal bleeding which was subsequently controlled and evaluated by imaging. Maxillofacial CT scan without contrast showed an expansile soft tissue mass at the right maxillary sinus measuring 3.4 x 3.5 x 3.7 cm with innumerable, similar lesions distributed throughout the cranial, cervical and visualized portions of the shoulder girdle bones. Biochemical evaluation was remarkable for PTH levels 1,229 pg/ml (nl, 18.5 – 88.0 pg/ml), corrected serum calcium 9.0 mg/dl (nl, 8.3 – 10.6 mg/dl), alkaline phosphate levels 391 U/L (nl, 46 – 116 U/L), serum phosphoros 5.5 mg/dl (nl, 2.5 – 4.5 mg/dl), calciferol levels 32.2 ng/ml (nl, 30 – 100 ng/ml) and an estimated glomerular filtration rate at 21 ml/min/1.73 m2 (nl, > 60 ml/min/1.73 m2). An excisional tissue biopsy showed osteoclastic-like multinucleated cells consistent with a brown tumor. These findings are consistent with secondary hyperparathyroidism complicated with osteitis fibrosa cystica. Following histologic diagnosis, a 99mTc-Sestamibi parathyroid scan showed two focal lesions of increased radiotracer uptake in the lower poles of the thyroid confirming parathyroid hyperplasia. Patient’s medical therapy was optimized by increasing cinacalcet dose and adding calcitriol, while continuing Sevelamer. Serum calcium, PTH, and phosphorous levels were closely monitored. Finally, patient was referred for parathyroidectomy. Patients with ESRD are at high risk of developing secondary hyperparathyroidism. Even with prior parathyroidectomy, these patients can develop disease recurrence. Early recognition and management of secondary hyperparathyroidism is crucial to decrease disease complications such as Brown tumors.

BROWN TUMOR RESULTING FROM SECONDARY HYPERPARATHYROIDISM IN CHRONIC RENAL DISEASE: A CASE REPORT

2017 ◽  
Vol 124 (2) ◽  
pp. e66
Author(s):  
LORENA CASTRO MARIANO ◽  
LETÍCIA DE SANTANA MASCARENHAS ◽  
ANTONIO MÁRCIO TEIXEIRA MARCHIONNI ◽  
DEYVID SILVA REBOUÇAS ◽  
JÚLIA DOS SANTOS VIANNA NERI ◽  
...  
Keyword(s):  
Case Report ◽  
Renal Disease ◽  
Secondary Hyperparathyroidism ◽  
Chronic Renal Disease ◽  
Brown Tumor

scholarly journals Brown Tumors: A Case Report and Review of the Literature

2016 ◽  
Vol 6 (1) ◽  
pp. 46-52 ◽  
Author(s):  
Özgür Can ◽  
Başak Boynueğri ◽  
Ali Murat Gökçe ◽  
Ebru Özdemir ◽  
Ferhat Ferhatoğlu ◽  
...  
Keyword(s):  
Case Report ◽  
Secondary Hyperparathyroidism ◽  
English Literature ◽  
Bone Lesions ◽  
Brown Tumor ◽  
Review Of The Literature ◽  
Normal Functions ◽  
Brown Tumors ◽  
Clinically Significant

Brown tumors are focal bone lesions, encountered in patients with uncontrolled hyperparathyroidism. They can be located in any part of the skeleton. Clinically significant lesions in the craniofacial bones are rare. Craniofacial involvement may cause facial disfiguration and compromise social ease of the patient and normal functions, such as chewing, talking, and breathing. In this case report, we present a patient with a brown tumor of the craniofacial bones provoked by secondary hyperparathyroidism and review the last 10 years of craniofacial brown tumors associated with secondary hyperparathyroidism in the English literature.

scholarly journals Case report of osteitis fibrosa cystica

2016 ◽  
Author(s):  
Engy AbdelWahab ◽  
Wael Farrag ◽  
Nesreen Qoutb ◽  
Yaser AbdelRaof
Keyword(s):  
Case Report ◽  
Osteitis Fibrosa ◽  
Osteitis Fibrosa Cystica

Bilateral maxillary osteoplasty with esthetic purpose in patient with secondary hyperparathyroidism-related brown tumor: case report

RSBO ◽  
2016 ◽  
Vol 13 (1) ◽  
pp. 41
Author(s):  
Bruna Da Fonseca Wastner ◽  
Vitor Hugo Candido Ferreira ◽  
Uliana Lucena Schussel ◽  
Roberta Targa Stramandinoli-Zanicotti ◽  
Laurindo Moacir Sassi
Keyword(s):  
Case Report ◽  
Secondary Hyperparathyroidism ◽  
Brown Tumor
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