Heat inactivation of extended half‐life factor VIII concentrates

Haemophilia ◽  
2019 ◽  
Vol 25 (2) ◽  
Author(s):  
Kara A. Fylling ◽  
Julie I. Tange ◽  
Dong Chen ◽  
Rajiv K. Pruthi
Keyword(s):  
Factor Viii ◽  
Half Life ◽  
Heat Inactivation ◽  
Factor Viii Concentrates ◽  
Life Factor

HALF-LIFE AND IN-VIVO RECOVERY OF HEATED FACTOR VIII CONCENTRATES

The Lancet ◽  
1986 ◽  
Vol 328 (8506) ◽  
pp. 571-572 ◽  
Author(s):  
M. Morfini ◽  
A. Messori ◽  
G. Longo ◽  
S. Cinotti ◽  
M. Matucci ◽  
...  
Keyword(s):  
Factor Viii ◽  
Half Life ◽  
Factor Viii Concentrates ◽  
In Vivo Recovery

Continuous infusion of extended half-life factor VIII (efmoroctocog alpha) for surgery in severe haemophilia A

Haemophilia ◽  
2018 ◽  
Vol 24 (4) ◽  
pp. e280-e283
Author(s):  
I. C. L. Kremer Hovinga ◽  
R. E. G. Schutgens ◽  
P. R. van der Valk ◽  
L. F. D. van Vulpen ◽  
E. P. Mauser-Bunschoten ◽  
...  
Keyword(s):  
Factor Viii ◽  
Continuous Infusion ◽  
Half Life ◽  
Haemophilia A ◽  
Severe Haemophilia ◽  
Life Factor

Enhanced Half-Life Recombinant Factor VIII Concentrates for Hemophilia A: Final Results from Extension Studies

2021 ◽  
Author(s):  
Matteo Nicola Dario Di Minno ◽  
Alessandro Di Minno ◽  
Ilenia Calcaterra ◽  
Ernesto Cimino ◽  
Francesco Dell'Aquila ◽  
...  
Keyword(s):  
Factor Viii ◽  
Half Life ◽  
Hemophilia A ◽  
Recombinant Factor Viii ◽  
Factor Viii Concentrates

scholarly journals Extended Half-Life Factor VIII/Factor IX Products: Assay Discrepancies and Implications for Hemophilia Management

2020 ◽  
Vol 40 (S 01) ◽  
pp. S15-S20
Author(s):  
Jens Müller ◽  
Georg Goldmann ◽  
Natascha Marquardt ◽  
Bernd Pötzsch ◽  
Johannes Oldenburg
Keyword(s):  
Factor Viii ◽  
Half Life ◽  
In Vitro Study ◽  
Factor Ix ◽  
University Hospital ◽  
Spiked Plasma ◽  
Structural Differences ◽  
The University ◽  
Life Factor

AbstractDue to structural differences between extended half-life (EHL) factor VIII (FVIII) or FIX products and equivalent plasma wild-type molecules used for assay calibration, reagent-dependent discrepancies during monitoring of FVIII- and FIX-replacement therapies with EHL products have been described. To assess the performance of available one-stage clotting and chromogenic substrate assays on the Siemens Atellica COAG 360 analyzer, an in vitro study using spiked plasma samples was performed. The described results confirm previously described findings and allowed allocation of each EHL product to an appropriate assay. In addition, corresponding EHL product–specific analytes were defined within the order entry system of the University Hospital Bonn. The requirement of product-specific FVIII and FIX assays complicates patient monitoring and demonstrates the need for both continuous education and communication between treating physicians and the coagulation laboratory.

Role of enhanced half-life factor VIII and IX in the treatment of haemophilia

2015 ◽  
Vol 169 (6) ◽  
pp. 768-776 ◽  
Author(s):  
Ali J. Mahdi ◽  
Samya G. Obaji ◽  
Peter W. Collins
Keyword(s):  
Factor Viii ◽  
Half Life ◽  
Viii And Ix ◽  
Life Factor

Extended half-life factor VIII for immune tolerance induction in haemophilia

Haemophilia ◽  
2016 ◽  
Vol 22 (6) ◽  
pp. e552-e554 ◽  
Author(s):  
L. M. Malec ◽  
J. Journeycake ◽  
M. V. Ragni
Keyword(s):  
Factor Viii ◽  
Immune Tolerance ◽  
Half Life ◽  
Tolerance Induction ◽  
Immune Tolerance Induction ◽  
Life Factor
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