Acquired von Willebrand syndrome in inflammatory bowel disease

Haemophilia ◽  
2017 ◽  
Vol 23 (3) ◽  
pp. e231-e233 ◽  
Author(s):  
A. Di Sabatino ◽  
C. Ambaglio ◽  
N. Aronico ◽  
N. Ghidelli ◽  
M. V. Lenti ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Acquired Von Willebrand Syndrome ◽  
Inflammatory Bowel ◽  
Von Willebrand

scholarly journals Circulating von Willebrand factor in inflammatory bowel disease.

Gut ◽  
1992 ◽  
Vol 33 (4) ◽  
pp. 502-506 ◽  
Author(s):  
T R Stevens ◽  
J P James ◽  
N J Simmonds ◽  
D A McCarthy ◽  
I F Laurenson ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Von Willebrand Factor ◽  
Bowel Disease ◽  
Inflammatory Bowel ◽  
Von Willebrand ◽  
Willebrand Factor

scholarly journals Recurrent Posterior Strokes in Inflammatory Bowel Disease Patients

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Amir Shaban ◽  
Brett Hymel ◽  
Maria Chavez-Keatts ◽  
Jordan J. Karlitz ◽  
Sheryl Martin-Schild
Keyword(s):  
Inflammatory Bowel Disease ◽  
Ischemic Stroke ◽  
Factor Viii ◽  
Bowel Disease ◽  
Medical Center ◽  
Hypercoagulable State ◽  
Stroke Registry ◽  
History Of ◽  
Inflammatory Bowel ◽  
Von Willebrand

Objective. To describe the stroke characteristics of patients with a history of inflammatory bowel disease (IBD).Background. A hypercoagulable state associated with IBD has been frequently implicated as a risk factor for ischemic stroke. Variable mechanisms and infrequent occurrence limit prospective clinical research on the association between IBD and stroke.Methods. We retrospectively reviewed consecutive patients with acute ischemic stroke presenting to our medical center from 7/2008 to 9/2013. Patients with a history of IBD were identified. Clinical variables were abstracted from our prospective stroke registry.Results. Over the period of five years we identified only three patients with a documented history of IBD. Each of these patients presented three times to our hospital with new strokes. Patients presented outside the window for intravenous tPA treatment on 8/9 admissions. Each one of our patients had posterior strokes on at least two separate occasions. Hypercoagulation panel showed elevated factor VIII with or without concomitant elevation of Von Willebrand factor (vWF) during almost every admission (8/9 admissions). Only one admission was associated with IBD flare.Conclusion. The association between IBD and posterior strokes is a novel finding. Factor VIII elevation may serve as a biomarker of a peristroke hypercoagulable state in patients with IBD.

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