The molecular basis of low activity levels of coagulation factor VII: a Brazilian cohort

Haemophilia ◽  
2015 ◽  
Vol 21 (5) ◽  
pp. 670-680 ◽  
Author(s):  
F.Y. Rabelo ◽  
L. L. Jardim ◽  
M. B. Landau ◽  
T. Gadelha ◽  
M. F. B. Corrêa ◽  
...  
Keyword(s):  
Molecular Basis ◽  
Coagulation Factor ◽  
Factor Vii ◽  
Activity Levels ◽  
Coagulation Factor Vii ◽  
Low Activity ◽  
Brazilian Cohort

scholarly journals Postprandial coagulation factor VII activity: the effect of monounsaturated fatty acids

1997 ◽  
Vol 77 (4) ◽  
pp. 537-549 ◽  
Author(s):  
Helen M. Roche ◽  
Michael J. Gibney
Keyword(s):  
Fatty Acids ◽  
Regression Analysis ◽  
Plasma Lipid ◽  
Area Under The Curve ◽  
Coagulation Factor ◽  
Random Order ◽  
Monounsaturated Fatty Acids ◽  
Factor Vii ◽  
Activity Levels ◽  
Coagulation Factor Vii

The present study investigated the effect of monounsaturated fatty acids (MUFA) on postprandial coagulation factor VII activity. Fifteen healthy male volunteers consumed three meals containing equal amounts (40g) of fat, but providing different proportions of MUFA (12,17 and 24% energy)in random order. Fasting and postprandial blood samples were drawn every hour for 9 h. The magnitude of the postprandial triacylglycerolaemic response and the postprandial plasma nonesterifled fatty acid (NEFA) concentrations were not significantly different following the three meals. Coagulation factor VII was activated during postprandial triacylglycerolaemia but the area under the curve of postprandial coagulation factor VII activity was not significantly different following the three meals. Regression analysis showed that fasting factor VII activity was the single mast important factor affecting postprandial factor VII activity, irrespective of plasma lipid concentrations and meal fat composition. Peak postprandial factor VII activity was attained significantly earlier following the high-MUFA meal compared with the low-MUFA meal (6·33 (SD 2·16) h, 3·60 (SD 1·81)h respectively; P = 0·016). Regression analysis showed that meal MUFA content was the primary determinant of time to peak postprandial factor VII activity. Although the magnitude of postprandial coagulation factor VII activity was not affected by meal MUFA content, peak postprandial factor VII activity occurred earlier and fasting activity levels were quickly restored following the high-MUFA meal. A short-lived increase in factor VII activity may be more beneficial than a prolonged thrombotic response.

Coagulation Factor VII, Dietary Fat and Blood Lipids: A Review

1996 ◽  
Vol 76 (04) ◽  
pp. 492-499 ◽  
Author(s):  
L I Mennen ◽  
E G Schouten ◽  
D E Grobbee ◽  
C Kluft
Keyword(s):  
Dietary Fat ◽  
Blood Lipids ◽  
Coagulation Factor ◽  
Factor Vii ◽  
Coagulation Factor Vii

A Polymorphic Cluster in the 5′ Region of the Human Coagulation Factor VII Gene: Detection, Frequency, and Linkage Disequilibrium

1997 ◽  
Vol 88 (5) ◽  
pp. 445-448 ◽  
Author(s):  
Giorgio Dell'Acqua ◽  
Licia Iacoviello ◽  
Andria D'Orazio ◽  
Rosa Di Bitondo ◽  
Augusto Di Castelnuovo ◽  
...  
Keyword(s):  
Linkage Disequilibrium ◽  
Coagulation Factor ◽  
Factor Vii ◽  
Gene Detection ◽  
Coagulation Factor Vii ◽  
Detection Frequency ◽  
Human Coagulation Factor Vii

Coagulation Factor VII and Plasma Triglycerides

1989 ◽  
Vol 19 (3) ◽  
pp. 125-130 ◽  
Author(s):  
J. Carvalho de Sousa ◽  
E. Bruckert ◽  
P. Giral ◽  
C. Soria ◽  
J. Chapman ◽  
...  
Keyword(s):  
Coagulation Factor ◽  
Factor Vii ◽  
Plasma Triglycerides ◽  
Coagulation Factor Vii

A case of an inhibitor autoantibody to coagulation factor VII

Haemophilia ◽  
2003 ◽  
Vol 9 (1) ◽  
pp. 119-120 ◽  
Author(s):  
C. Aguilar ◽  
J. F. Lucía ◽  
P. Hernández
Keyword(s):  
Coagulation Factor ◽  
Factor Vii ◽  
Coagulation Factor Vii

scholarly journals Circulating Tissue Factor Procoagulant Activity and Thrombin Generation in Patients with Type 2 Diabetes: Effects of Insulin and Glucose

2007 ◽  
Vol 92 (11) ◽  
pp. 4352-4358 ◽  
Author(s):  
Guenther Boden ◽  
Vijender R. Vaidyula ◽  
Carol Homko ◽  
Peter Cheung ◽  
A. Koneti Rao
Keyword(s):  
Type 2 Diabetes ◽  
Tissue Factor ◽  
Blood Coagulation ◽  
Coagulation Factor ◽  
Procoagulant Activity ◽  
Factor Vii ◽  
Coagulation Factor Vii ◽  
Glucose Levels ◽  
Study Protocols

Abstract Context: Type 2 diabetes mellitus (T2DM) is a hypercoagulable state. Tissue factor (TF) is the principal initiator of blood coagulation. Objective: Our objective was to examine the effects of hyperglycemia and hyperinsulinemia on the TF pathway of blood coagulation in T2DM. Design: Three study protocols were used: 1) acute correction of hyperglycemia (with iv insulin) followed by 24 h of euglycemia, 2) 24 h of selective hyperinsulinemia, and 3) 24 h of combined hyperinsulinemia and hyperglycemia. Setting: The study took place at a clinical research center. Study Participants: Participants included 18 T2DM patients and 22 nondiabetic controls. Results: Basal TF-procoagulant activity (TF-PCA), monocyte TF mRNA, plasma coagulation factor VII (FVIIc), and thrombin-anti-thrombin complexes were higher in T2DM than in nondiabetic controls, indicating a chronic procoagulant state. Acutely normalizing hyperglycemia over 2–4 h resulted in a small (∼7%) but significant decline in TF-PCA with no further decline over 24 h. Raising insulin levels alone raised TF-PCA by 30%, whereas raising insulin and glucose levels together increased TF-PCA (by 80%), thrombin-anti-thrombin complexes, and prothrombin fragment 1.2. Plasma FVIIa and FVIIc declined with increases in TF-PCA. Conclusion: We conclude that the combination of hyperglycemia and hyperinsulinemia, common in poorly controlled patients with T2DM, contributes to a procoagulant state that may predispose these patients to acute cardiovascular events.

Intracellular readthrough of nonsense mutations by aminoglycosides in coagulation factor VII

2006 ◽  
Vol 4 (6) ◽  
pp. 1308-1314 ◽  
Author(s):  
M. PINOTTI ◽  
L. RIZZOTTO ◽  
P. PINTON ◽  
P. FERRARESI ◽  
A. CHUANSUMRIT ◽  
...  
Keyword(s):  
Coagulation Factor ◽  
Factor Vii ◽  
Nonsense Mutations ◽  
Coagulation Factor Vii
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