scholarly journals Long‐term treatment course of a patient with mild haemophilia A who developed a high titre factor VIII inhibitor

Haemophilia ◽  
2014 ◽  
Vol 20 (6) ◽  
Author(s):  
F. Iioka ◽  
D. Shimomura ◽  
F. Nakamura ◽  
H. Ohno ◽  
K. Yada ◽  
...  
Keyword(s):  
Factor Viii ◽  
High Titre ◽  
Term Treatment ◽  
Factor Viii Inhibitor ◽  
Haemophilia A ◽  
Long Term Treatment ◽  
Viii Inhibitor ◽  
Mild Haemophilia

Successful liver transplantation in a patient with severe haemophilia A and a high-titre factor VIII inhibitor

Haemophilia ◽  
2004 ◽  
Vol 10 (6) ◽  
pp. 735-737 ◽  
Author(s):  
A. A. Ashrani ◽  
M. T. Reding ◽  
A. Shet ◽  
J. Osip ◽  
A. Humar ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Factor Viii ◽  
High Titre ◽  
Factor Viii Inhibitor ◽  
Haemophilia A ◽  
Severe Haemophilia ◽  
Viii Inhibitor

Successful long-time treatment with mycophenolate-mofetil in a child with acquired factor VIII inhibitor

2012 ◽  
Vol 32 (S 01) ◽  
pp. S75-S78 ◽  
Author(s):  
C. Niekrens ◽  
K.-W. Sykora ◽  
C. Wermes
Keyword(s):  
Factor Viii ◽  
Half Life ◽  
High Titer ◽  
Term Treatment ◽  
High Dose ◽  
Severe Bleeding ◽  
Factor Viii Inhibitor ◽  
Long Term Treatment ◽  
Viii Inhibitor ◽  
Acquired Factor Viii Inhibitor

SummaryHere, we report about a boy (age: 18 years) who developed an acquired factor VIII inhibitor at the age of 9 years. He presented with bleeding in his right ankle, multiple haematomas and a high-titer factor VIII type II inhibitor (400 BU). Therapy: He received treatment with MMF (CellCept→), dexamethasoneimmunoglobulin pulses, and rituximab together with high dose FVIII (Hannover protocol). His inhibitor titer decreased rapidly, and half-life and recovery normalized. Inhibitor titres increased after reduction of the factor VIII dose, and increased further after MMF was stopped. A second treatment course with MMF again resulted in reduction of the titre, improvement in half life and recovery, and no more bleedings. Inhibitor reappeared with MMF dose reduction, again accompanied by severe bleeding. Additional rituximab stopped the bleedings, and treatment with MMF has been continued since. Conclusion: Although the laboratory parameters showed no complete remission, severe bleedings and expensive factor replacement could be avoided by long-term treatment with MMF.

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